A predictive model of hospitalisation and death from chronic obstructive pulmonary disease

Stuart Schembri, William Anderson, Steve Morant, Janet Winter, Philip Thompson, Daniel Pettitt, Thomas M. MacDonald, John H. Winter

    Research output: Contribution to journalArticle

    46 Citations (Scopus)

    Abstract

    Rationale: A recent study showed that doctors are excessively pessimistic about the prognosis in patients with COPD and suggested that a simple tool. to predict outcome is needed.

    Methods: In a prospective observational study, 3343 patients with an FEV1 < 80% of the predicted value and FEV1/FVC < 70% were selected from a clinical. network of patients screened for COPD in Tayside, Scotland. Data were collected during annual visits on demography, spirometry, smoking history, medical research council (MRC) dyspnoea scale, body mass index (BMI) and other variables. The main outcome measures were hospitalisations and death secondary to COPD. A proportional hazard model was used to identify significant risk factors.

    Results: Increasing age, low BMI, worsening MRC dyspnoea score, decreased FEV1, and prior respiratory or cardiovascular admission hospitalisation were predictors of poor outcome. Influenza vaccination was protective.

    Conclusion: We have developed a model. that estimates the risk of respiratory hospitalisation and death in patients with COPD. (C) 2009 Elsevier Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)1461-1467
    Number of pages7
    JournalRespiratory Medicine
    Volume103
    Issue number10
    DOIs
    Publication statusPublished - Oct 2009

    Keywords

    • COPD
    • Predictive model
    • Hospitalisation
    • Death
    • HEALTH-STATUS
    • COPD PATIENTS
    • SURVIVAL
    • HYPOXEMIA
    • MORTALITY
    • TERM
    • CARE

    Cite this

    Schembri, S., Anderson, W., Morant, S., Winter, J., Thompson, P., Pettitt, D., MacDonald, T. M., & Winter, J. H. (2009). A predictive model of hospitalisation and death from chronic obstructive pulmonary disease. Respiratory Medicine, 103(10), 1461-1467. https://doi.org/10.1016/j.rmed.2009.04.021