A proteomic signature for CNS adaptations to the valence of environmental stimulation

Andrew Shaw, Luke D. Arnold, Lucia Privitera, Phillip D. Whitfield, Mary K. Doherty, Lorenzo Morè

Research output: Contribution to journalArticle

Abstract

Environmental Enrichment leads to a significant improvement in long-term performance across a range of cognitive functions in mammals and it has been shown to produce an increased synaptic density and neurogenesis. Nevertheless it is still an open question as to whether some key aspects of spatial learning & memory and procedural learning might be embodied by different molecular pathways to those of social cognition. Associated with synaptic changes and potentially underlying conditions, the Ras-ERK pathway has been proposed to be the primary mediator of in vivo adaptations to environmental enrichment, acting via the downstream Ras-ERK signalling kinase MSK1 and the transcription factor CREB. Herein, we show that valence of environmental stimulation increased social competition and that this is associated with a specific proteomic signature in the frontal lobe but notably not in the hippocampus. Specifically, we show that altering the valence of environmental stimuli affected the level of social competition, with mice from negatively enriched environments winning significantly more encounters-even though mice from positive were bigger and should display dominance. This behavioural phenotype was accompanied by changes in the proteome of the fronto-ventral pole of the brain, with a differential increase in the relative abundance of proteins involved in the mitochondrial metabolic processes of the TCA cycle and respiratory processes. Investigation of this proteomic signature may pave the way for the elucidation of novel pathways underpinning the behavioural changes caused by negative enrichment and further out understanding of conditions whose core feature is increased social competition.

Original languageEnglish
Article number112515
JournalBehavioural Brain Research
Volume383
Early online date29 Jan 2020
DOIs
Publication statusE-pub ahead of print - 29 Jan 2020

Fingerprint

Proteomics
Cognition
MAP Kinase Signaling System
Neurogenesis
Frontal Lobe
Proteome
Mammals
Hippocampus
Transcription Factors
Phosphotransferases
Learning
Phenotype
Brain
Proteins
Spatial Learning

Keywords

  • Environmental enrichment
  • Frontal pole
  • Hippocampus
  • Proteomics
  • Ras-ERK pathway
  • Social competition

Cite this

Shaw, Andrew ; Arnold, Luke D. ; Privitera, Lucia ; Whitfield, Phillip D. ; Doherty, Mary K. ; Morè, Lorenzo. / A proteomic signature for CNS adaptations to the valence of environmental stimulation. In: Behavioural Brain Research. 2020 ; Vol. 383.
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A proteomic signature for CNS adaptations to the valence of environmental stimulation. / Shaw, Andrew; Arnold, Luke D.; Privitera, Lucia; Whitfield, Phillip D.; Doherty, Mary K.; Morè, Lorenzo.

In: Behavioural Brain Research, Vol. 383, 112515, 06.04.2020.

Research output: Contribution to journalArticle

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AU - Arnold, Luke D.

AU - Privitera, Lucia

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