A Prototype Therapeutic Capsule Endoscope for Ultrasound-mediated Targeted Drug Delivery

Fraser Stewart; Antonella  Verbeni; Yongqiang  Qiu; Benjamin Cox; Jan Vorstius; Ian Newton; Zhihong Huang; Arianna Menciassi; Inke Nathke; Sandy Cochran

doi:10.1142/S2424905X18400019

A Prototype Therapeutic Capsule Endoscope for Ultrasound-mediated Targeted Drug Delivery

Fraser Stewart, Antonella Verbeni, Yongqiang Qiu, Benjamin Cox, Jan Vorstius, Ian Newton, Zhihong Huang, Arianna Menciassi, Inke Nathke, Sandy Cochran (Lead / Corresponding author)

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16 Citations (Scopus)

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Abstract

The prevalence of gastrointestinal (GI) diseases such as Crohn’s disease, which is chronic and incurable, are increasing worldwide. Treatment often involves potent drugs with unwanted side effects. The technological–pharmacological combination of capsule endoscopy with ultrasound-mediated targeted drug delivery (UmTDD) described in this paper carries new potential for treatment of these diseases throughout the GI tract. We describe a proof-of-concept UmTDD capsule and present preliminary results to demonstrate its promise as an autonomous tool to treat GI diseases.

Original language	English
Article number	1840001
Number of pages	13
Journal	Journal of Medical Robotics Research
Volume	3
Issue number	2
Early online date	15 Feb 2018
DOIs	https://doi.org/10.1142/S2424905X18400019
Publication status	Published - Jun 2018

Keywords

Capsule endoscopy
therapy
focused ultrasound
drug delivery
UmTDD
ultrasound capsule endoscopy (USCE)

Access to Document

10.1142/S2424905X18400019

Author Accepted ManuscriptAccepted author manuscript, 682 KB

Sonopill: Minimally Invasive Gastrointestinal Diagnosis and Therapy (Joint with University of Glasgow & Heriot Watt University)
Cochran, S. (Investigator), Corner, G. (Investigator), Cuschieri, A. (Investigator), Nathke, I. (Investigator) & Steele, B. (Investigator)
Engineering and Physical Sciences Research Council
27/05/13 → 14/12/18
Project: Research

Vorstius, Jan Bernd
- Mechanical and Industrial Engineering - Senior Lecturer (Teaching and Research)
Person: Academic

Cite this

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title = "A Prototype Therapeutic Capsule Endoscope for Ultrasound-mediated Targeted Drug Delivery",

abstract = "The prevalence of gastrointestinal (GI) diseases such as Crohn{\textquoteright}s disease, which is chronic and incurable, are increasing worldwide. Treatment often involves potent drugs with unwanted side effects. The technological–pharmacological combination of capsule endoscopy with ultrasound-mediated targeted drug delivery (UmTDD) described in this paper carries new potential for treatment of these diseases throughout the GI tract. We describe a proof-of-concept UmTDD capsule and present preliminary results to demonstrate its promise as an autonomous tool to treat GI diseases.",

keywords = "Capsule endoscopy, therapy, focused ultrasound, drug delivery, UmTDD, ultrasound capsule endoscopy (USCE)",

author = "Fraser Stewart and Antonella Verbeni and Yongqiang Qiu and Benjamin Cox and Jan Vorstius and Ian Newton and Zhihong Huang and Arianna Menciassi and Inke Nathke and Sandy Cochran",

note = "Financial support from the UK Engineering and Physical Sciences Research Council, Grant EP/K034537 (Sonopill Programme) is gratefully acknowledged.",

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doi = "10.1142/S2424905X18400019",

language = "English",

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T1 - A Prototype Therapeutic Capsule Endoscope for Ultrasound-mediated Targeted Drug Delivery

AU - Stewart, Fraser

AU - Verbeni, Antonella

AU - Qiu, Yongqiang

AU - Cox, Benjamin

AU - Vorstius, Jan

AU - Newton, Ian

AU - Huang, Zhihong

AU - Menciassi, Arianna

AU - Nathke, Inke

AU - Cochran, Sandy

N1 - Financial support from the UK Engineering and Physical Sciences Research Council, Grant EP/K034537 (Sonopill Programme) is gratefully acknowledged.

PY - 2018/6

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N2 - The prevalence of gastrointestinal (GI) diseases such as Crohn’s disease, which is chronic and incurable, are increasing worldwide. Treatment often involves potent drugs with unwanted side effects. The technological–pharmacological combination of capsule endoscopy with ultrasound-mediated targeted drug delivery (UmTDD) described in this paper carries new potential for treatment of these diseases throughout the GI tract. We describe a proof-of-concept UmTDD capsule and present preliminary results to demonstrate its promise as an autonomous tool to treat GI diseases.

AB - The prevalence of gastrointestinal (GI) diseases such as Crohn’s disease, which is chronic and incurable, are increasing worldwide. Treatment often involves potent drugs with unwanted side effects. The technological–pharmacological combination of capsule endoscopy with ultrasound-mediated targeted drug delivery (UmTDD) described in this paper carries new potential for treatment of these diseases throughout the GI tract. We describe a proof-of-concept UmTDD capsule and present preliminary results to demonstrate its promise as an autonomous tool to treat GI diseases.

KW - Capsule endoscopy

KW - therapy

KW - focused ultrasound

KW - drug delivery

KW - UmTDD

KW - ultrasound capsule endoscopy (USCE)

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DO - 10.1142/S2424905X18400019

M3 - Article

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JO - Journal of Medical Robotics Research

JF - Journal of Medical Robotics Research

IS - 2

M1 - 1840001

ER -

A Prototype Therapeutic Capsule Endoscope for Ultrasound-mediated Targeted Drug Delivery

Abstract

Keywords

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Projects

Sonopill: Minimally Invasive Gastrointestinal Diagnosis and Therapy (Joint with University of Glasgow & Heriot Watt University)

Profiles

Vorstius, Jan Bernd

Cite this