A Prototype Therapeutic Capsule Endoscope for Ultrasound-mediated Targeted Drug Delivery

Fraser Stewart, Antonella Verbeni, Yongqiang Qiu, Benjamin Cox, Jan Vorstius, Ian Newton, Zhihong Huang, Arianna Menciassi, Inke Nathke, Sandy Cochran (Lead / Corresponding author)

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Abstract

The prevalence of gastrointestinal (GI) diseases such as Crohn’s disease, which is chronic and incurable, are increasing worldwide. Treatment often involves potent drugs with unwanted side effects. The technological–pharmacological combination of capsule endoscopy with ultrasound-mediated targeted drug delivery (UmTDD) described in this paper carries new potential for treatment of these diseases throughout the GI tract. We describe a proof-of-concept UmTDD capsule and present preliminary results to demonstrate its promise as an autonomous tool to treat GI diseases.
Original languageEnglish
Article number1840001
Number of pages13
JournalJournal of Medical Robotics Research
Volume3
Issue number2
Early online date15 Feb 2018
DOIs
Publication statusPublished - Jun 2018

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Keywords

  • Capsule endoscopy
  • therapy
  • focused ultrasound
  • drug delivery
  • UmTDD
  • ultrasound capsule endoscopy (USCE)

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