A QSAR study investigating the effect of L-alanine ester variation on the anti-HIV activity of some phosphoramidate derivatives of d4T

Michael H. Knaggs; Christopher McGuigan; Sarah A.  Harris; Parissa Heshmati; Dominique Cahard; Ian H.  Gilbert; Jan Balzarini

doi:10.1016/S0960-894X(00)00397-8

A QSAR study investigating the effect of _L-alanine ester variation on the anti-HIV activity of some phosphoramidate derivatives of d4T

Michael H. Knaggs, Christopher McGuigan, Sarah A. Harris, Parissa Heshmati, Dominique Cahard, Ian H. Gilbert, Jan Balzarini

Research output: Contribution to journal › Article › peer-review

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Abstract

A QSAR study, involving the use of calculated physical properties (TSAR^TM), and the use of a neural network approach (TSAR^TM), has been performed concerning the anti-HIV activity and cytotoxic effects of a series of d4T phosphoramidate derivatives with varying _L-alanine esters. Models were obtained which allow reliable predictions for the anti-HIV activity, and cytotoxicity, of these derivatives. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	2075-2078
Number of pages	4
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	10
Issue number	18
DOIs	https://doi.org/10.1016/S0960-894X(00)00397-8
Publication status	Published - Sept 2000

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10.1016/S0960-894X(00)00397-8

Cite this

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title = "A QSAR study investigating the effect of L-alanine ester variation on the anti-HIV activity of some phosphoramidate derivatives of d4T",

abstract = "A QSAR study, involving the use of calculated physical properties (TSARTM), and the use of a neural network approach (TSARTM), has been performed concerning the anti-HIV activity and cytotoxic effects of a series of d4T phosphoramidate derivatives with varying L-alanine esters. Models were obtained which allow reliable predictions for the anti-HIV activity, and cytotoxicity, of these derivatives. (C) 2000 Elsevier Science Ltd. All rights reserved.",

author = "Knaggs, {Michael H.} and Christopher McGuigan and Harris, {Sarah A.} and Parissa Heshmati and Dominique Cahard and Gilbert, {Ian H.} and Jan Balzarini",

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AU - Knaggs, Michael H.

AU - McGuigan, Christopher

AU - Harris, Sarah A.

AU - Heshmati, Parissa

AU - Cahard, Dominique

AU - Gilbert, Ian H.

AU - Balzarini, Jan

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AB - A QSAR study, involving the use of calculated physical properties (TSARTM), and the use of a neural network approach (TSARTM), has been performed concerning the anti-HIV activity and cytotoxic effects of a series of d4T phosphoramidate derivatives with varying L-alanine esters. Models were obtained which allow reliable predictions for the anti-HIV activity, and cytotoxicity, of these derivatives. (C) 2000 Elsevier Science Ltd. All rights reserved.

U2 - 10.1016/S0960-894X(00)00397-8

DO - 10.1016/S0960-894X(00)00397-8

M3 - Article

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JO - Bioorganic & Medicinal Chemistry Letters

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