A QSAR study investigating the effect of L-alanine ester variation on the anti-HIV activity of some phosphoramidate derivatives of d4T

Michael H. Knaggs, Christopher McGuigan, Sarah A. Harris, Parissa Heshmati, Dominique Cahard, Ian H. Gilbert, Jan Balzarini

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    Abstract

    A QSAR study, involving the use of calculated physical properties (TSARTM), and the use of a neural network approach (TSARTM), has been performed concerning the anti-HIV activity and cytotoxic effects of a series of d4T phosphoramidate derivatives with varying L-alanine esters. Models were obtained which allow reliable predictions for the anti-HIV activity, and cytotoxicity, of these derivatives. (C) 2000 Elsevier Science Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)2075-2078
    Number of pages4
    JournalBioorganic & Medicinal Chemistry Letters
    Volume10
    Issue number18
    DOIs
    Publication statusPublished - Sep 2000

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