A Rare Case of a Non-Invasive Vaginal Urothelial Carcinoma Demonstrating a Clonal Relationship With a Metachronous Non-Invasive Bladder Urothelial Carcinoma

TY - JOUR

T1 - A Rare Case of a Non-Invasive Vaginal Urothelial Carcinoma Demonstrating a Clonal Relationship With a Metachronous Non-Invasive Bladder Urothelial Carcinoma

AU - Hill, Cassandra

AU - Ghazanfar, Noman

AU - Chuang, Andy

AU - Hislop, Robert Gordon

AU - Rathod, Ketan

AU - Wilson, Jamie

AU - Nandwani, Ghulam Mustafa

PY - 2026/9/17

Y1 - 2026/9/17

N2 - Non-invasive vaginal urothelial carcinomas (UCs) are extremely rare and are almost always associated with a non-invasive bladder UC. The pathogenesis of these rare vaginal lesions is uncertain. They may represent a primary vaginal tumour or they may arise from a urinary tract UC, in which tumour cells “seed” by non-invasive mechanisms. We describe a case of a non-invasive vaginal UC, occurring 6 years following treatment of a non-invasive bladder UC, managed with an anterior pelvic exenteration and followed up over 5 years. Molecular analysis using a genome-wide single nucleotide polymorphism (SNP) microarray to assess copy number variations and regions of copy number neutral loss of heterozygosity (CN-LOH) was performed on both tumours. These results evidence a clonal relationship between these two tumours indicating that the vaginal tumour is the result of non-invasive tumour “seeding” from the original bladder lesion. To our knowledge this is the first case report to demonstrate clonality between metachronous non-invasive bladder and vaginal UCs.

AB - Non-invasive vaginal urothelial carcinomas (UCs) are extremely rare and are almost always associated with a non-invasive bladder UC. The pathogenesis of these rare vaginal lesions is uncertain. They may represent a primary vaginal tumour or they may arise from a urinary tract UC, in which tumour cells “seed” by non-invasive mechanisms. We describe a case of a non-invasive vaginal UC, occurring 6 years following treatment of a non-invasive bladder UC, managed with an anterior pelvic exenteration and followed up over 5 years. Molecular analysis using a genome-wide single nucleotide polymorphism (SNP) microarray to assess copy number variations and regions of copy number neutral loss of heterozygosity (CN-LOH) was performed on both tumours. These results evidence a clonal relationship between these two tumours indicating that the vaginal tumour is the result of non-invasive tumour “seeding” from the original bladder lesion. To our knowledge this is the first case report to demonstrate clonality between metachronous non-invasive bladder and vaginal UCs.

U2 - 10.1155/crip/4360431

DO - 10.1155/crip/4360431

M3 - Article

SN - 2090-6781

VL - 2026

JO - Case Reports in Pathology

JF - Case Reports in Pathology

IS - 1

M1 - 4360431

ER -