A record-linkage study of the development of hepatocellular carcinoma in persons with hepatitis C infection in Scotland

TY - JOUR

T1 - A record-linkage study of the development of hepatocellular carcinoma in persons with hepatitis C infection in Scotland

AU - McDonald, S. A.

AU - Hutchinson, S. J.

AU - Bird, S. M.

AU - Robertson, C.

AU - Mills, P. R.

AU - Dillon, J. F.

AU - Goldberg, D. J.

N1 - Times Cited: 4

PY - 2008

Y1 - 2008

N2 - We investigated trends in first-time hospital admissions and deaths attributable to hepatocellular carcinoma (HCC) in a large population-based cohort of 22 073 individuals diagnosed with hepatitis C viral (HCV) infection through laboratory testing in Scotland in 1991-2006. We identified new cases of HCC through record-linkage to the national inpatient hospital discharge database and deaths registry. A total of 172 persons diagnosed with HCV were admitted to hospital or died with first-time mention of HCC. Hepatocellular carcinoma incidence increased between 1996 and 2006 ( average annual change of 6.1, 95% confidence interval (CI): 0.9-11.6%, P = 0.021). The adjusted relative risk of HCC was greater for males ( hazard ratio 2.7, 95% CI: 1.7-4.2), for those aged 60 years or older ( hazard ratio 2.7, 95% CI: 1.9-4.1) compared with 50-59 years, and for those with a previous alcohol-related hospital admission ( hazard ratio 2.5, 95% CI: 1.7-3.7). The risk of individuals diagnosed with HCV developing HCC was greatly increased compared with the general Scottish population ( standardised incidence ratio 127, 95% CI: 102-156). Owing to the advancing age of the Scottish HCV-diagnosed population, the annual number of HCC cases is projected to increase, with a consequent increasing burden on the public healthcare system.

AB - We investigated trends in first-time hospital admissions and deaths attributable to hepatocellular carcinoma (HCC) in a large population-based cohort of 22 073 individuals diagnosed with hepatitis C viral (HCV) infection through laboratory testing in Scotland in 1991-2006. We identified new cases of HCC through record-linkage to the national inpatient hospital discharge database and deaths registry. A total of 172 persons diagnosed with HCV were admitted to hospital or died with first-time mention of HCC. Hepatocellular carcinoma incidence increased between 1996 and 2006 ( average annual change of 6.1, 95% confidence interval (CI): 0.9-11.6%, P = 0.021). The adjusted relative risk of HCC was greater for males ( hazard ratio 2.7, 95% CI: 1.7-4.2), for those aged 60 years or older ( hazard ratio 2.7, 95% CI: 1.9-4.1) compared with 50-59 years, and for those with a previous alcohol-related hospital admission ( hazard ratio 2.5, 95% CI: 1.7-3.7). The risk of individuals diagnosed with HCV developing HCC was greatly increased compared with the general Scottish population ( standardised incidence ratio 127, 95% CI: 102-156). Owing to the advancing age of the Scottish HCV-diagnosed population, the annual number of HCC cases is projected to increase, with a consequent increasing burden on the public healthcare system.

KW - hepatocellular carcinoma

KW - hepatitis C

KW - record-linkage study

KW - alcohol

KW - VIRUS-INFECTION

KW - NATURAL-HISTORY

KW - LIVER-CIRRHOSIS

KW - HEALTH BURDEN

KW - UNITED-STATES

KW - CANCER

KW - PROGRESSION

KW - ALCOHOL

KW - RISK

KW - FIBROSIS

U2 - 10.1038/sj.bjc.6604563

DO - 10.1038/sj.bjc.6604563

M3 - Article

C2 - 18728670

SN - 0007-0920

VL - 99

SP - 805

EP - 810

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 5

ER -