A retrospective cohort study to evaluate the relationship of airway hyperresponsiveness to type 2 biomarkers in persistent asthma

Rory Chan, Chris RuiWen Kuo, Brian Lipworth (Lead / Corresponding author)

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Abstract

Airway hyperresponsiveness (AHR) is a hallmark of persistent asthma measured using direct or indirect airway bronchial challenge testing. The purpose of this study is to investigate the putative relationships between type 2 inflammatory biomarkers, airway geometry (FEV1 and FEF25-75) and specific IgE (RAST or skin prick) to AHR. We performed a retrospective analysis of our database (n = 131) of patients with asthma. Of these subjects, 75 had a histamine challenge and 56 had a mannitol challenge. Fractional exhaled nitric oxide (FeNO) and specific immunoglobulin E (IgE) but not blood eosinophils were significantly higher in patients with AHR to either histamine or mannitol. FEV1 % and FEF25 - 75 % were significantly lower in patients with AHR. Elevated Type 2 biomarkers including FeNO and specific IgE but not blood eosinophils were associated with AHR.
Original languageEnglish
Pages (from-to)008-013
Number of pages6
JournalArchives of Asthma, Allergy and Immunology
Volume5
Issue number1
DOIs
Publication statusPublished - 17 Feb 2021

Keywords

  • Airway hyperresponsiveness
  • Asthma
  • Allergy
  • Type 2 inflammation
  • FeNO

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