A review of the analytical techniques for the detection of anabolic–androgenic steroids within biological matrices

Richard L. Harries; Giorgia De Paoli; Sarah Hall; Lorna A. Nisbet

doi:10.1002/wfs2.1504

A review of the analytical techniques for the detection of anabolic–androgenic steroids within biological matrices

Richard L. Harries, Giorgia De Paoli, Sarah Hall, Lorna A. Nisbet

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Abstract

Anabolic–androgenic steroids (AASs) and other image and performance enhancing drugs (IPEDs) are controlled by governments and sport institutions such as the World Anti-doping Agency (WADA). Although elite athletes and professional bodybuilders are the most visible AAS abusers, the introduction of the internet has increased the accessibility of AASs, with use being observed among recreational gym goers at increasing prevalence. Despite reported increase in use, routine analysis for these substances is uncommon, with many forensic laboratories opting to outsource AAS analysis. This review collates information regarding the extraction and analysis of AASs from various biological matrices with the considered purpose of providing a reference for the development of AAS methods to allow for routine detection by forensic laboratories.

Original language	English
Article number	e1504
Number of pages	24
Journal	WIREs Forensic Science
Early online date	3 Oct 2023
DOIs	https://doi.org/10.1002/wfs2.1504
Publication status	E-pub ahead of print - 3 Oct 2023

Keywords

AAS
steroids
toxicology

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10.1002/wfs2.1504Licence: CC BY

Final Published VersionFinal published version, 2.96 MBLicence: CC BY

Leverhulme Research Centre for Forensic Science (LRCFS)
Nic Daeid, N. (Investigator)
Leverhulme Trust
1/07/16 → 30/06/26
Project: Research

Cite this

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title = "A review of the analytical techniques for the detection of anabolic–androgenic steroids within biological matrices",

abstract = "Anabolic–androgenic steroids (AASs) and other image and performance enhancing drugs (IPEDs) are controlled by governments and sport institutions such as the World Anti-doping Agency (WADA). Although elite athletes and professional bodybuilders are the most visible AAS abusers, the introduction of the internet has increased the accessibility of AASs, with use being observed among recreational gym goers at increasing prevalence. Despite reported increase in use, routine analysis for these substances is uncommon, with many forensic laboratories opting to outsource AAS analysis. This review collates information regarding the extraction and analysis of AASs from various biological matrices with the considered purpose of providing a reference for the development of AAS methods to allow for routine detection by forensic laboratories.",

keywords = "AAS, steroids, toxicology",

author = "Harries, {Richard L.} and {De Paoli}, Giorgia and Sarah Hall and Nisbet, {Lorna A.}",

note = "Funding Information: Leverhulme Trust. Grant Number: RC-2015-01. Copyright: {\textcopyright} 2023 The Authors. WIREs Forensic Science published by Wiley Periodicals LLC.",

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doi = "10.1002/wfs2.1504",

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AU - Harries, Richard L.

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AU - Nisbet, Lorna A.

PY - 2023/10/3

Y1 - 2023/10/3

N2 - Anabolic–androgenic steroids (AASs) and other image and performance enhancing drugs (IPEDs) are controlled by governments and sport institutions such as the World Anti-doping Agency (WADA). Although elite athletes and professional bodybuilders are the most visible AAS abusers, the introduction of the internet has increased the accessibility of AASs, with use being observed among recreational gym goers at increasing prevalence. Despite reported increase in use, routine analysis for these substances is uncommon, with many forensic laboratories opting to outsource AAS analysis. This review collates information regarding the extraction and analysis of AASs from various biological matrices with the considered purpose of providing a reference for the development of AAS methods to allow for routine detection by forensic laboratories.

AB - Anabolic–androgenic steroids (AASs) and other image and performance enhancing drugs (IPEDs) are controlled by governments and sport institutions such as the World Anti-doping Agency (WADA). Although elite athletes and professional bodybuilders are the most visible AAS abusers, the introduction of the internet has increased the accessibility of AASs, with use being observed among recreational gym goers at increasing prevalence. Despite reported increase in use, routine analysis for these substances is uncommon, with many forensic laboratories opting to outsource AAS analysis. This review collates information regarding the extraction and analysis of AASs from various biological matrices with the considered purpose of providing a reference for the development of AAS methods to allow for routine detection by forensic laboratories.

KW - AAS

KW - steroids

KW - toxicology

U2 - 10.1002/wfs2.1504

DO - 10.1002/wfs2.1504

M3 - Article

SN - 2573-9468

JO - WIREs Forensic Science

JF - WIREs Forensic Science

M1 - e1504

ER -

A review of the analytical techniques for the detection of anabolic–androgenic steroids within biological matrices

Abstract

Keywords

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Leverhulme Research Centre for Forensic Science (LRCFS)

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