A Role for Dormant Origins in Tumor Suppression

Kathleen Klotz-Noack, J. Julian Blow

    Research output: Contribution to journalEditorialpeer-review

    6 Citations (Scopus)

    Abstract

    In this issue of Molecular Cell, Kawabata et al. (2011) show that mice hypomorphic for the replication licensing protein Mcm4 show spontaneous DNA replication defects due to a lack of dormant origins, potentially explaining why these mice are cancer prone.

    Original languageEnglish
    Pages (from-to)495-496
    Number of pages2
    JournalMolecular Cell
    Volume41
    Issue number5
    DOIs
    Publication statusPublished - 4 Mar 2011

    Keywords

    • REPLICATIVE STRESS
    • EXCESS MCM2-7
    • CANCER
    • MICE

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