A SET/MYND chromatin re-modelling protein regulates Dictyostelium prespore patterning

Beatriz Nunez-Corcuera, Joanna Birch, Jeffrey G. Williams

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)


    SmdA is a Dictyosteliumorthologue of the SET/MYND chromatin re-modelling proteins. In developing structures derived from a null mutant for smdA (a smdA- strain), prestalk patterning is normal, but using a prespore lacZ reporter fusion, there is ectopic accumulation of beta-galactosidase in the prestalk region. As wild type slugs migrate, there is continual forward movement and redifferentiation of prespore cells into prestalk cells. Thus, a potential explanation for the ectopic reporter localization in smdA null prestalk cells is an increased rate of re-differentiation and anterior movement of prespore cells. In support of this notion, analysis of an unstable lacZ reporter, driven by the prespore promoter, reveals a normal staining pattern in the smdA- strain. We suggest that one or more genes regulated by SmdA acts to repress prespore re-specification.

    Original languageEnglish
    Pages (from-to)205-208
    Number of pages4
    JournalInternational Journal of Developmental Biology
    Issue number2
    Publication statusPublished - 2011


    • Dictyostelium
    • SET/MYND
    • Prespore
    • Cell sorting
    • Histone methyltransferase
    • Cells
    • Discoideum
    • Identification
    • Transcription
    • SMYD3
    • Gene


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