A study of 5-HT-receptors associated with afferent nerves located in normal and inflamed rat ankle joints

B. D. Grubb; D. S. McQueen; A. Iggo; G. J. Birrell; M. B. Dutia

doi:10.1007/BF01965015

A study of 5-HT-receptors associated with afferent nerves located in normal and inflamed rat ankle joints

B. D. Grubb, D. S. McQueen, A. Iggo, G. J. Birrell, M. B. Dutia

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

Neural recordings were made from sensory fibres in a nerve supplying the ankle joint in normal rats and in rats with a novel monoarticular arthritis. The responses of mechanically and chemically sensitive units to intra-arterial injections of 5-HT were measured. In most cases the mechanosensitivity of sensory receptors in the ankle joint was not altered by 5-HT. However, 5-HT produced an increase in afferent activity in units which were identified as C-fibres on the basis of action potential amplitude and duration. The receptive fields of these chemosensitive units were not located. The responses of these units to 5-HT were dose dependent and were abolished by the 5-HT₂-antogonist, ketanserin, but not by the 5-HT₃-receptor antagonist, MDL 72222. The responses of chemosensitive units to injections of 5-HT were similar in normal and arthritic rats although the response was slightly prolonged in arthritic animals.

Original language	English
Pages (from-to)	216-218
Number of pages	3
Journal	Agents and Actions
Volume	25
Issue number	3-4
DOIs	https://doi.org/10.1007/BF01965015
Publication status	Published - 1 Sept 1988

Keywords

ARTHRITIS
Receptive Field
Afferent Nerve
Ankle Joint
Sensory Fibre

ASJC Scopus subject areas

Toxicology
Pharmacology (medical)

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10.1007/BF01965015

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title = "A study of 5-HT-receptors associated with afferent nerves located in normal and inflamed rat ankle joints",

abstract = "Neural recordings were made from sensory fibres in a nerve supplying the ankle joint in normal rats and in rats with a novel monoarticular arthritis. The responses of mechanically and chemically sensitive units to intra-arterial injections of 5-HT were measured. In most cases the mechanosensitivity of sensory receptors in the ankle joint was not altered by 5-HT. However, 5-HT produced an increase in afferent activity in units which were identified as C-fibres on the basis of action potential amplitude and duration. The receptive fields of these chemosensitive units were not located. The responses of these units to 5-HT were dose dependent and were abolished by the 5-HT2-antogonist, ketanserin, but not by the 5-HT3-receptor antagonist, MDL 72222. The responses of chemosensitive units to injections of 5-HT were similar in normal and arthritic rats although the response was slightly prolonged in arthritic animals.",

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author = "Grubb, {B. D.} and McQueen, {D. S.} and A. Iggo and Birrell, {G. J.} and Dutia, {M. B.}",

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AU - Grubb, B. D.

AU - McQueen, D. S.

AU - Iggo, A.

AU - Birrell, G. J.

AU - Dutia, M. B.

PY - 1988/9/1

Y1 - 1988/9/1

N2 - Neural recordings were made from sensory fibres in a nerve supplying the ankle joint in normal rats and in rats with a novel monoarticular arthritis. The responses of mechanically and chemically sensitive units to intra-arterial injections of 5-HT were measured. In most cases the mechanosensitivity of sensory receptors in the ankle joint was not altered by 5-HT. However, 5-HT produced an increase in afferent activity in units which were identified as C-fibres on the basis of action potential amplitude and duration. The receptive fields of these chemosensitive units were not located. The responses of these units to 5-HT were dose dependent and were abolished by the 5-HT2-antogonist, ketanserin, but not by the 5-HT3-receptor antagonist, MDL 72222. The responses of chemosensitive units to injections of 5-HT were similar in normal and arthritic rats although the response was slightly prolonged in arthritic animals.

AB - Neural recordings were made from sensory fibres in a nerve supplying the ankle joint in normal rats and in rats with a novel monoarticular arthritis. The responses of mechanically and chemically sensitive units to intra-arterial injections of 5-HT were measured. In most cases the mechanosensitivity of sensory receptors in the ankle joint was not altered by 5-HT. However, 5-HT produced an increase in afferent activity in units which were identified as C-fibres on the basis of action potential amplitude and duration. The receptive fields of these chemosensitive units were not located. The responses of these units to 5-HT were dose dependent and were abolished by the 5-HT2-antogonist, ketanserin, but not by the 5-HT3-receptor antagonist, MDL 72222. The responses of chemosensitive units to injections of 5-HT were similar in normal and arthritic rats although the response was slightly prolonged in arthritic animals.

KW - ARTHRITIS

KW - Receptive Field

KW - Afferent Nerve

KW - Ankle Joint

KW - Sensory Fibre

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ER -

A study of 5-HT-receptors associated with afferent nerves located in normal and inflamed rat ankle joints

Abstract

Keywords

ASJC Scopus subject areas

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