A study of 5-HT-receptors associated with afferent nerves located in normal and inflamed rat ankle joints

B. D. Grubb, D. S. McQueen, A. Iggo, G. J. Birrell, M. B. Dutia

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    55 Citations (Scopus)

    Abstract

    Neural recordings were made from sensory fibres in a nerve supplying the ankle joint in normal rats and in rats with a novel monoarticular arthritis. The responses of mechanically and chemically sensitive units to intra-arterial injections of 5-HT were measured. In most cases the mechanosensitivity of sensory receptors in the ankle joint was not altered by 5-HT. However, 5-HT produced an increase in afferent activity in units which were identified as C-fibres on the basis of action potential amplitude and duration. The receptive fields of these chemosensitive units were not located. The responses of these units to 5-HT were dose dependent and were abolished by the 5-HT2-antogonist, ketanserin, but not by the 5-HT3-receptor antagonist, MDL 72222. The responses of chemosensitive units to injections of 5-HT were similar in normal and arthritic rats although the response was slightly prolonged in arthritic animals.

    Original languageEnglish
    Pages (from-to)216-218
    Number of pages3
    JournalAgents and Actions
    Volume25
    Issue number3-4
    DOIs
    Publication statusPublished - 1 Sep 1988

    Keywords

    • ARTHRITIS
    • Receptive Field
    • Afferent Nerve
    • Ankle Joint
    • Sensory Fibre

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