A study of whole blood platelet and white cell aggregation using a laser flow aggregometer

J. Sun, E. W. Abel, A. Bancroft, M. McLaren, J. J. F. Belch

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Both platelet aggregation and white blood cell aggregation are involved in pathological processes such as thrombosis, atherosclerosis and chronic inflammation. People in older age groups are likely to suffer from cardiovascular diseases and may have increased white cell and platelet aggregation which could contribute to this increased risk. This study aimed to compare white cell and platelet aggregation between different age and gender groups. Whole blood white cell aggregation and platelet aggregation were carried out on healthy volunteers using cytometric techniques. It was found that both white cell and platelet aggregation in the elderly group (white cell aggregation median value, 0.08; range, 0.02-0.14; platelet aggregation median value, 0.32; range, 0.1-0.39) were significantly higher (P = 0.017 for white cell aggregation, P = 0.007 for platelet aggregation) than in the younger group (white cell aggregation median value, 0.05; range, 0.01-0.14; platelet aggregation median value, 0.18; range, 0.07-0.36). No significant differences were found between the gender groups.
    Original languageEnglish
    Pages (from-to)103-108
    Number of pages6
    JournalPlatelets
    Volume14
    Issue number2
    DOIs
    Publication statusPublished - 2003

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    Cell Aggregation
    Platelet Aggregation
    Lasers
    Blood Platelets
    Age Groups
    Pathologic Processes
    Atherosclerosis
    Healthy Volunteers
    Thrombosis
    Leukocytes
    Cardiovascular Diseases
    Inflammation

    Cite this

    Sun, J. ; Abel, E. W. ; Bancroft, A. ; McLaren, M. ; Belch, J. J. F. / A study of whole blood platelet and white cell aggregation using a laser flow aggregometer. In: Platelets. 2003 ; Vol. 14, No. 2. pp. 103-108.
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    abstract = "Both platelet aggregation and white blood cell aggregation are involved in pathological processes such as thrombosis, atherosclerosis and chronic inflammation. People in older age groups are likely to suffer from cardiovascular diseases and may have increased white cell and platelet aggregation which could contribute to this increased risk. This study aimed to compare white cell and platelet aggregation between different age and gender groups. Whole blood white cell aggregation and platelet aggregation were carried out on healthy volunteers using cytometric techniques. It was found that both white cell and platelet aggregation in the elderly group (white cell aggregation median value, 0.08; range, 0.02-0.14; platelet aggregation median value, 0.32; range, 0.1-0.39) were significantly higher (P = 0.017 for white cell aggregation, P = 0.007 for platelet aggregation) than in the younger group (white cell aggregation median value, 0.05; range, 0.01-0.14; platelet aggregation median value, 0.18; range, 0.07-0.36). No significant differences were found between the gender groups.",
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    A study of whole blood platelet and white cell aggregation using a laser flow aggregometer. / Sun, J.; Abel, E. W.; Bancroft, A.; McLaren, M.; Belch, J. J. F.

    In: Platelets, Vol. 14, No. 2, 2003, p. 103-108.

    Research output: Contribution to journalArticle

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    AU - Sun, J.

    AU - Abel, E. W.

    AU - Bancroft, A.

    AU - McLaren, M.

    AU - Belch, J. J. F.

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    AB - Both platelet aggregation and white blood cell aggregation are involved in pathological processes such as thrombosis, atherosclerosis and chronic inflammation. People in older age groups are likely to suffer from cardiovascular diseases and may have increased white cell and platelet aggregation which could contribute to this increased risk. This study aimed to compare white cell and platelet aggregation between different age and gender groups. Whole blood white cell aggregation and platelet aggregation were carried out on healthy volunteers using cytometric techniques. It was found that both white cell and platelet aggregation in the elderly group (white cell aggregation median value, 0.08; range, 0.02-0.14; platelet aggregation median value, 0.32; range, 0.1-0.39) were significantly higher (P = 0.017 for white cell aggregation, P = 0.007 for platelet aggregation) than in the younger group (white cell aggregation median value, 0.05; range, 0.01-0.14; platelet aggregation median value, 0.18; range, 0.07-0.36). No significant differences were found between the gender groups.

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