A sweet TET-a-tete-synergy of TET proteins and O-GlcNAc transferase in transcription

    Research output: Contribution to journalEditorial

    5 Citations (Scopus)

    Abstract

    5-hydroxy methyl cytosine (5hmC) is a modification identified in vertebrates several decades ago. More recently, a possible role of 5hmC as an epigenetic modifier and/or transcriptional regulator has started to emerge, with altered levels in early embryonic development, embryonic stem (ES) cell differentiation and tumours (Tahiliani et al, 2009; Yang et al, 2012). The balance between 5hmC and 5-methyl cytosine (5mC) at gene promoters and CpG islands in the genome appears to be linked to pluripotency and lineage commitment of a cell (Ito et al, 2010). However, proteins with 5hmC binding capability have not yet been identified, and it has been proposed that 5hmC may only be a reaction intermediate in the process of demethylation (He et al, 2011; Ito et al, 2011). Over the last few years, ten-eleven translocation (Tet) family proteins have been shown to be responsible for the conversion of 5mC to 5hmC (Iyer et al, 2009; Loenarz and Schofield, 2009; Tahiliani et al, 2009). However, how Tet family proteins and 5hmC are linked to transcriptional regulation is currently not clear.

    Original languageEnglish
    Pages (from-to)612-613
    Number of pages2
    JournalEMBO Journal
    Volume32
    Issue number5
    DOIs
    Publication statusPublished - 2013

    Keywords

    • 5-METHYLCYTOSINE
    • 5-CARBOXYLCYTOSINE
    • MAMMALIAN DNA
    • CONVERSION

    Cite this

    @article{b4b9f342a4c849978e2ec288b6c7b21f,
    title = "A sweet TET-a-tete-synergy of TET proteins and O-GlcNAc transferase in transcription",
    abstract = "5-hydroxy methyl cytosine (5hmC) is a modification identified in vertebrates several decades ago. More recently, a possible role of 5hmC as an epigenetic modifier and/or transcriptional regulator has started to emerge, with altered levels in early embryonic development, embryonic stem (ES) cell differentiation and tumours (Tahiliani et al, 2009; Yang et al, 2012). The balance between 5hmC and 5-methyl cytosine (5mC) at gene promoters and CpG islands in the genome appears to be linked to pluripotency and lineage commitment of a cell (Ito et al, 2010). However, proteins with 5hmC binding capability have not yet been identified, and it has been proposed that 5hmC may only be a reaction intermediate in the process of demethylation (He et al, 2011; Ito et al, 2011). Over the last few years, ten-eleven translocation (Tet) family proteins have been shown to be responsible for the conversion of 5mC to 5hmC (Iyer et al, 2009; Loenarz and Schofield, 2009; Tahiliani et al, 2009). However, how Tet family proteins and 5hmC are linked to transcriptional regulation is currently not clear.",
    keywords = "5-METHYLCYTOSINE, 5-CARBOXYLCYTOSINE, MAMMALIAN DNA, CONVERSION",
    author = "Daniel Mariappa and Shalini Pathak and {van Aalten}, {Daan M. F.}",
    year = "2013",
    doi = "10.1038/emboj.2013.26",
    language = "English",
    volume = "32",
    pages = "612--613",
    journal = "EMBO Journal",
    issn = "0261-4189",
    publisher = "EMBO Press",
    number = "5",

    }

    A sweet TET-a-tete-synergy of TET proteins and O-GlcNAc transferase in transcription. / Mariappa, Daniel; Pathak, Shalini; van Aalten, Daan M. F.

    In: EMBO Journal, Vol. 32, No. 5, 2013, p. 612-613.

    Research output: Contribution to journalEditorial

    TY - JOUR

    T1 - A sweet TET-a-tete-synergy of TET proteins and O-GlcNAc transferase in transcription

    AU - Mariappa, Daniel

    AU - Pathak, Shalini

    AU - van Aalten, Daan M. F.

    PY - 2013

    Y1 - 2013

    N2 - 5-hydroxy methyl cytosine (5hmC) is a modification identified in vertebrates several decades ago. More recently, a possible role of 5hmC as an epigenetic modifier and/or transcriptional regulator has started to emerge, with altered levels in early embryonic development, embryonic stem (ES) cell differentiation and tumours (Tahiliani et al, 2009; Yang et al, 2012). The balance between 5hmC and 5-methyl cytosine (5mC) at gene promoters and CpG islands in the genome appears to be linked to pluripotency and lineage commitment of a cell (Ito et al, 2010). However, proteins with 5hmC binding capability have not yet been identified, and it has been proposed that 5hmC may only be a reaction intermediate in the process of demethylation (He et al, 2011; Ito et al, 2011). Over the last few years, ten-eleven translocation (Tet) family proteins have been shown to be responsible for the conversion of 5mC to 5hmC (Iyer et al, 2009; Loenarz and Schofield, 2009; Tahiliani et al, 2009). However, how Tet family proteins and 5hmC are linked to transcriptional regulation is currently not clear.

    AB - 5-hydroxy methyl cytosine (5hmC) is a modification identified in vertebrates several decades ago. More recently, a possible role of 5hmC as an epigenetic modifier and/or transcriptional regulator has started to emerge, with altered levels in early embryonic development, embryonic stem (ES) cell differentiation and tumours (Tahiliani et al, 2009; Yang et al, 2012). The balance between 5hmC and 5-methyl cytosine (5mC) at gene promoters and CpG islands in the genome appears to be linked to pluripotency and lineage commitment of a cell (Ito et al, 2010). However, proteins with 5hmC binding capability have not yet been identified, and it has been proposed that 5hmC may only be a reaction intermediate in the process of demethylation (He et al, 2011; Ito et al, 2011). Over the last few years, ten-eleven translocation (Tet) family proteins have been shown to be responsible for the conversion of 5mC to 5hmC (Iyer et al, 2009; Loenarz and Schofield, 2009; Tahiliani et al, 2009). However, how Tet family proteins and 5hmC are linked to transcriptional regulation is currently not clear.

    KW - 5-METHYLCYTOSINE

    KW - 5-CARBOXYLCYTOSINE

    KW - MAMMALIAN DNA

    KW - CONVERSION

    U2 - 10.1038/emboj.2013.26

    DO - 10.1038/emboj.2013.26

    M3 - Editorial

    VL - 32

    SP - 612

    EP - 613

    JO - EMBO Journal

    JF - EMBO Journal

    SN - 0261-4189

    IS - 5

    ER -