Projects per year
Abstract
5-hydroxy methyl cytosine (5hmC) is a modification identified in vertebrates several decades ago. More recently, a possible role of 5hmC as an epigenetic modifier and/or transcriptional regulator has started to emerge, with altered levels in early embryonic development, embryonic stem (ES) cell differentiation and tumours (Tahiliani et al, 2009; Yang et al, 2012). The balance between 5hmC and 5-methyl cytosine (5mC) at gene promoters and CpG islands in the genome appears to be linked to pluripotency and lineage commitment of a cell (Ito et al, 2010). However, proteins with 5hmC binding capability have not yet been identified, and it has been proposed that 5hmC may only be a reaction intermediate in the process of demethylation (He et al, 2011; Ito et al, 2011). Over the last few years, ten-eleven translocation (Tet) family proteins have been shown to be responsible for the conversion of 5mC to 5hmC (Iyer et al, 2009; Loenarz and Schofield, 2009; Tahiliani et al, 2009). However, how Tet family proteins and 5hmC are linked to transcriptional regulation is currently not clear.
Original language | English |
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Pages (from-to) | 612-613 |
Number of pages | 2 |
Journal | EMBO Journal |
Volume | 32 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2013 |
Keywords
- 5-METHYLCYTOSINE
- 5-CARBOXYLCYTOSINE
- MAMMALIAN DNA
- CONVERSION
Fingerprint
Dive into the research topics of 'A sweet TET-a-tete-synergy of TET proteins and O-GlcNAc transferase in transcription'. Together they form a unique fingerprint.Projects
- 2 Finished
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Aref#d: 21559. Molecular Mechanisms of Fungal Cell Wall Assembly (Programme Grant)
1/11/09 → 31/10/14
Project: Research
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Aref#d: 21318. Molecular Mechanisms of O-GlcNAc Signalling (Senior Fellowship Renewal)
1/06/09 → 29/02/16
Project: Research