A synthetic acceptor substrate for Trypanosoma brucei UDP-Gal: GPI anchor side-chain alpha-galactosyltransferases

Jillian R. Brown, Terry K. Smith, Michael A. J. Ferguson, Robert A. Field

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    Abstract

    A synthetic analogue of a trisaccharide fragment of the Trypanosoma brucei Variant Surface Glycoprotein (VSG) GlycosylPhosphatidylInositiol (GPI) anchor, Gal-alpha-1,3(Man-alpha-1,6)-Man-alpha-O-octyl (1), serves as a substrate for two T. brucei alpha-galactosyltransferases. The principle tetrasaccharide product derived from (1) contains a Gal-alpha-1,2-Gal linkage. (C) 1998 Elsevier Science Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)2051-2054
    Number of pages4
    JournalBioorganic & Medicinal Chemistry Letters
    Volume8
    Issue number15
    DOIs
    Publication statusPublished - 4 Aug 1998

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