A synthetic acceptor substrate for Trypanosoma brucei UDP-Gal: GPI anchor side-chain alpha-galactosyltransferases

Jillian R. Brown; Terry K.  Smith; Michael A. J.  Ferguson; Robert A. Field

doi:10.1016/S0960-894X(98)00359-X

A synthetic acceptor substrate for Trypanosoma brucei UDP-Gal: GPI anchor side-chain alpha-galactosyltransferases

Jillian R. Brown
, Terry K. Smith
, Michael A. J. Ferguson
, Robert A. Field

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

A synthetic analogue of a trisaccharide fragment of the Trypanosoma brucei Variant Surface Glycoprotein (VSG) GlycosylPhosphatidylInositiol (GPI) anchor, Gal-alpha-1,3(Man-alpha-1,6)-Man-alpha-O-octyl (1), serves as a substrate for two T. brucei alpha-galactosyltransferases. The principle tetrasaccharide product derived from (1) contains a Gal-alpha-1,2-Gal linkage. (C) 1998 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	2051-2054
Number of pages	4
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	8
Issue number	15
DOIs	https://doi.org/10.1016/S0960-894X(98)00359-X
Publication status	Published - 4 Aug 1998

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title = "A synthetic acceptor substrate for Trypanosoma brucei UDP-Gal: GPI anchor side-chain alpha-galactosyltransferases",

abstract = "A synthetic analogue of a trisaccharide fragment of the Trypanosoma brucei Variant Surface Glycoprotein (VSG) GlycosylPhosphatidylInositiol (GPI) anchor, Gal-alpha-1,3(Man-alpha-1,6)-Man-alpha-O-octyl (1), serves as a substrate for two T. brucei alpha-galactosyltransferases. The principle tetrasaccharide product derived from (1) contains a Gal-alpha-1,2-Gal linkage. (C) 1998 Elsevier Science Ltd. All rights reserved.",

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TY - JOUR

T1 - A synthetic acceptor substrate for Trypanosoma brucei UDP-Gal

T2 - GPI anchor side-chain alpha-galactosyltransferases

AU - Brown, Jillian R.

AU - Smith, Terry K.

AU - Ferguson, Michael A. J.

AU - Field, Robert A.

PY - 1998/8/4

Y1 - 1998/8/4

N2 - A synthetic analogue of a trisaccharide fragment of the Trypanosoma brucei Variant Surface Glycoprotein (VSG) GlycosylPhosphatidylInositiol (GPI) anchor, Gal-alpha-1,3(Man-alpha-1,6)-Man-alpha-O-octyl (1), serves as a substrate for two T. brucei alpha-galactosyltransferases. The principle tetrasaccharide product derived from (1) contains a Gal-alpha-1,2-Gal linkage. (C) 1998 Elsevier Science Ltd. All rights reserved.

AB - A synthetic analogue of a trisaccharide fragment of the Trypanosoma brucei Variant Surface Glycoprotein (VSG) GlycosylPhosphatidylInositiol (GPI) anchor, Gal-alpha-1,3(Man-alpha-1,6)-Man-alpha-O-octyl (1), serves as a substrate for two T. brucei alpha-galactosyltransferases. The principle tetrasaccharide product derived from (1) contains a Gal-alpha-1,2-Gal linkage. (C) 1998 Elsevier Science Ltd. All rights reserved.

U2 - 10.1016/S0960-894X(98)00359-X

DO - 10.1016/S0960-894X(98)00359-X

M3 - Article

SN - 0960-894X

VL - 8

SP - 2051

EP - 2054

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 15

ER -

A synthetic acceptor substrate for Trypanosoma brucei UDP-Gal: GPI anchor side-chain alpha-galactosyltransferases

Abstract

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