A systematic review of polymer composite in biomedical engineering

Bankole I. Oladapo, S. Abolfazl Zahedi, Francis T. Omigbodun

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)


This review focuses on 3D printing of calcium hydroxyapatite (cHAp) as a composite on poly-ether-ether-ketone (PEEK) scaffolds and related structures. The combination is made of cHAp and coated biocompatible PEEK, a composite material with improved mechanical, thermal and flow properties for biocompatibility and bone implant. The interactions of the PEEK/cHAp interfaces that allow biological fusion are investigated for new biomedical applications. This research demonstrates biocompatibility by reviewing conventional coating techniques for HAp and PEEK fusion interfaces and in vitro and in vivo studies of the interactions between proteins and composite. A cell study of interactions between cHAp and PEEK biomolecules and how these interactions are affected by specific pre-adsorption of proteins is discussed. This study offers concise knowledge and understanding of the nanomaterials used as modifiers for improving biological behaviours of PEEK/cHAp nanocomposites in bone implants and tissue engineering. The main applications of 3D printed cHAp scaffolds in bone tissue engineering are presented and discussed. This review emphasises the most recent development and testing of multifunctional cHAp-based systems combining multiple properties for advanced therapies such as bone regeneration, antibacterial effect angiogenesis and cancer treatment.

Original languageEnglish
Article number110534
Number of pages12
JournalEuropean Polymer Journal
Early online date23 May 2021
Publication statusPublished - 5 Jul 2021


  • Biofunctionality
  • Biomaterial
  • Bone implant
  • PEEK composite
  • Tissue engineering

ASJC Scopus subject areas

  • General Physics and Astronomy
  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry


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