TY - JOUR
T1 - A trimer plus a dimer-gallate reproduce the bioactivity described for an extract of grape seed procyanidins
AU - Montagut , Gemma
AU - Baiges, Isabel
AU - Valls, Josep
AU - Terra, Ximena
AU - del Bas, Joseph M.
AU - Vitrac, Xavier
AU - Richard, Tristan
AU - Mérillon, Jean-Michel
AU - Arola, Lluis
AU - Blay, Mayte
AU - Bladé, Cinta
AU - Fernández-Larrea, Juan
AU - Pujadas, Gerard
AU - Salvadó, Josepa
AU - Ardévol, Anna
N1 - Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2009/9
Y1 - 2009/9
N2 - The relationship between grape seed-derived procyanidin extract components and their bioactivity was explored. The monomeric and dimeric structures only acted as anti-inflammatory agents. Similarly, pure C1 trimer was highly effective on LPS-activated macrophages. To reproduce all of the bioactivities of the total extract, a fraction enriched with trimeric structures was needed. This trimeric-enriched fraction was divided into subfractions, the most bioactive of which contained two compounds with a molecular weight equal to a trimer (865) and a dimer-gallate (729), according to spectrometric analysis. Thus, it may be concluded that a mixture of both molecules reproduces the bioactivity in glucose metabolism (3T3-L1), lipid metabolism (HepG2) and macrophage functionality (RAW 264.6).
AB - The relationship between grape seed-derived procyanidin extract components and their bioactivity was explored. The monomeric and dimeric structures only acted as anti-inflammatory agents. Similarly, pure C1 trimer was highly effective on LPS-activated macrophages. To reproduce all of the bioactivities of the total extract, a fraction enriched with trimeric structures was needed. This trimeric-enriched fraction was divided into subfractions, the most bioactive of which contained two compounds with a molecular weight equal to a trimer (865) and a dimer-gallate (729), according to spectrometric analysis. Thus, it may be concluded that a mixture of both molecules reproduces the bioactivity in glucose metabolism (3T3-L1), lipid metabolism (HepG2) and macrophage functionality (RAW 264.6).
UR - http://www.scopus.com/inward/record.url?scp=64449083487&partnerID=8YFLogxK
U2 - 10.1016/j.foodchem.2009.02.044
DO - 10.1016/j.foodchem.2009.02.044
M3 - Article
AN - SCOPUS:64449083487
SN - 0308-8146
VL - 116
SP - 265
EP - 270
JO - Food Chemistry
JF - Food Chemistry
IS - 1
ER -