A trimer plus a dimer-gallate reproduce the bioactivity described for an extract of grape seed procyanidins

Gemma Montagut , Isabel Baiges, Josep Valls, Ximena Terra, Joseph M. del Bas, Xavier Vitrac, Tristan Richard, Jean-Michel Mérillon, Lluis Arola, Mayte Blay, Cinta Bladé, Juan Fernández-Larrea, Gerard Pujadas, Josepa Salvadó, Anna Ardévol

    Research output: Contribution to journalArticlepeer-review

    28 Citations (Scopus)

    Abstract

    The relationship between grape seed-derived procyanidin extract components and their bioactivity was explored. The monomeric and dimeric structures only acted as anti-inflammatory agents. Similarly, pure C1 trimer was highly effective on LPS-activated macrophages. To reproduce all of the bioactivities of the total extract, a fraction enriched with trimeric structures was needed. This trimeric-enriched fraction was divided into subfractions, the most bioactive of which contained two compounds with a molecular weight equal to a trimer (865) and a dimer-gallate (729), according to spectrometric analysis. Thus, it may be concluded that a mixture of both molecules reproduces the bioactivity in glucose metabolism (3T3-L1), lipid metabolism (HepG2) and macrophage functionality (RAW 264.6).
    Original languageEnglish
    Pages (from-to)265-270
    Number of pages6
    JournalFood Chemistry
    Volume116
    Issue number1
    DOIs
    Publication statusPublished - Sep 2009

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