A trimer plus a dimer-gallate reproduce the bioactivity described for an extract of grape seed procyanidins

Gemma Montagut; Isabel Baiges; Josep Valls; Ximena Terra; Joseph M. del Bas; Xavier Vitrac; Tristan Richard; Jean-Michel Mérillon; Lluis Arola; Mayte Blay; Cinta Bladé; Juan Fernández-Larrea; Gerard Pujadas; Josepa Salvadó; Anna Ardévol

doi:10.1016/j.foodchem.2009.02.044

A trimer plus a dimer-gallate reproduce the bioactivity described for an extract of grape seed procyanidins

Gemma Montagut
, Isabel Baiges
, Josep Valls
, Ximena Terra
, Joseph M. del Bas
, Xavier Vitrac
, Tristan Richard
, Jean-Michel Mérillon
, Lluis Arola
, Mayte Blay
, Cinta Bladé
, Juan Fernández-Larrea
, Gerard Pujadas
, Josepa Salvadó
, Anna Ardévol

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

The relationship between grape seed-derived procyanidin extract components and their bioactivity was explored. The monomeric and dimeric structures only acted as anti-inflammatory agents. Similarly, pure C1 trimer was highly effective on LPS-activated macrophages. To reproduce all of the bioactivities of the total extract, a fraction enriched with trimeric structures was needed. This trimeric-enriched fraction was divided into subfractions, the most bioactive of which contained two compounds with a molecular weight equal to a trimer (865) and a dimer-gallate (729), according to spectrometric analysis. Thus, it may be concluded that a mixture of both molecules reproduces the bioactivity in glucose metabolism (3T3-L1), lipid metabolism (HepG2) and macrophage functionality (RAW 264.6).

Original language	English
Pages (from-to)	265-270
Number of pages	6
Journal	Food Chemistry
Volume	116
Issue number	1
DOIs	https://doi.org/10.1016/j.foodchem.2009.02.044
Publication status	Published - Sept 2009

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10.1016/j.foodchem.2009.02.044

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Montagut , G., Baiges, I., Valls, J., Terra, X., del Bas, J. M., Vitrac, X., Richard, T., Mérillon, J.-M., Arola, L., Blay, M., Bladé, C., Fernández-Larrea, J., Pujadas, G., Salvadó, J., & Ardévol, A. (2009). A trimer plus a dimer-gallate reproduce the bioactivity described for an extract of grape seed procyanidins. Food Chemistry, 116(1), 265-270. https://doi.org/10.1016/j.foodchem.2009.02.044

@article{8acb848c91224a45a5757d474774661d,

title = "A trimer plus a dimer-gallate reproduce the bioactivity described for an extract of grape seed procyanidins",

abstract = "The relationship between grape seed-derived procyanidin extract components and their bioactivity was explored. The monomeric and dimeric structures only acted as anti-inflammatory agents. Similarly, pure C1 trimer was highly effective on LPS-activated macrophages. To reproduce all of the bioactivities of the total extract, a fraction enriched with trimeric structures was needed. This trimeric-enriched fraction was divided into subfractions, the most bioactive of which contained two compounds with a molecular weight equal to a trimer (865) and a dimer-gallate (729), according to spectrometric analysis. Thus, it may be concluded that a mixture of both molecules reproduces the bioactivity in glucose metabolism (3T3-L1), lipid metabolism (HepG2) and macrophage functionality (RAW 264.6).",

author = "Gemma Montagut and Isabel Baiges and Josep Valls and Ximena Terra and \{del Bas\}, \{Joseph M.\} and Xavier Vitrac and Tristan Richard and Jean-Michel M{\'e}rillon and Lluis Arola and Mayte Blay and Cinta Blad{\'e} and Juan Fern{\'a}ndez-Larrea and Gerard Pujadas and Josepa Salvad{\'o} and Anna Ard{\'e}vol",

year = "2009",

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doi = "10.1016/j.foodchem.2009.02.044",

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Montagut , G, Baiges, I, Valls, J, Terra, X, del Bas, JM, Vitrac, X, Richard, T, Mérillon, J-M, Arola, L, Blay, M, Bladé, C, Fernández-Larrea, J, Pujadas, G, Salvadó, J & Ardévol, A 2009, 'A trimer plus a dimer-gallate reproduce the bioactivity described for an extract of grape seed procyanidins', Food Chemistry, vol. 116, no. 1, pp. 265-270. https://doi.org/10.1016/j.foodchem.2009.02.044

TY - JOUR

T1 - A trimer plus a dimer-gallate reproduce the bioactivity described for an extract of grape seed procyanidins

AU - Montagut , Gemma

AU - Baiges, Isabel

AU - Valls, Josep

AU - Terra, Ximena

AU - del Bas, Joseph M.

AU - Vitrac, Xavier

AU - Richard, Tristan

AU - Mérillon, Jean-Michel

AU - Arola, Lluis

AU - Blay, Mayte

AU - Bladé, Cinta

AU - Fernández-Larrea, Juan

AU - Pujadas, Gerard

AU - Salvadó, Josepa

AU - Ardévol, Anna

PY - 2009/9

Y1 - 2009/9

N2 - The relationship between grape seed-derived procyanidin extract components and their bioactivity was explored. The monomeric and dimeric structures only acted as anti-inflammatory agents. Similarly, pure C1 trimer was highly effective on LPS-activated macrophages. To reproduce all of the bioactivities of the total extract, a fraction enriched with trimeric structures was needed. This trimeric-enriched fraction was divided into subfractions, the most bioactive of which contained two compounds with a molecular weight equal to a trimer (865) and a dimer-gallate (729), according to spectrometric analysis. Thus, it may be concluded that a mixture of both molecules reproduces the bioactivity in glucose metabolism (3T3-L1), lipid metabolism (HepG2) and macrophage functionality (RAW 264.6).

AB - The relationship between grape seed-derived procyanidin extract components and their bioactivity was explored. The monomeric and dimeric structures only acted as anti-inflammatory agents. Similarly, pure C1 trimer was highly effective on LPS-activated macrophages. To reproduce all of the bioactivities of the total extract, a fraction enriched with trimeric structures was needed. This trimeric-enriched fraction was divided into subfractions, the most bioactive of which contained two compounds with a molecular weight equal to a trimer (865) and a dimer-gallate (729), according to spectrometric analysis. Thus, it may be concluded that a mixture of both molecules reproduces the bioactivity in glucose metabolism (3T3-L1), lipid metabolism (HepG2) and macrophage functionality (RAW 264.6).

UR - https://www.scopus.com/pages/publications/64449083487

U2 - 10.1016/j.foodchem.2009.02.044

DO - 10.1016/j.foodchem.2009.02.044

M3 - Article

AN - SCOPUS:64449083487

SN - 0308-8146

VL - 116

SP - 265

EP - 270

JO - Food Chemistry

JF - Food Chemistry

IS - 1

ER -

A trimer plus a dimer-gallate reproduce the bioactivity described for an extract of grape seed procyanidins

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