A unified approach to evolutionary conservation and population constraint in protein domains highlights structural features and pathogenic sites

Keyphrases

• Unified Approach 100%
• Protein Domain 100%
• Structural Features 100%
• Evolutionary Conservation 100%
• Missense 100%
• Evolutionary Population 100%
• Pathogenicity 50%
• Missense Variants 50%
• Enrichment Score 50%
• Prediction Model 25%
• 3D Structure 25%
• In(III) 25%
• Molecular Evolution 25%
• Protein-protein Interaction 25%
• Mutagenesis 25%
• Specificity Protein 1 25%
• Ligand-binding Domain 25%
• Protein Data Bank 25%
• Protein-ligand 25%
• Functional Studies 25%
• P450s 25%
• Multiple Sequence Alignment 25%
• Human Population 25%
• Electron Donor 25%
• Single Species 25%
• Small Molecule Drugs 25%
• Evolutionarily Conserved 25%
• Human Proteome 25%
• Protein-ligand Interaction 25%
• Receptor-ligand Binding 25%
• Ligand Binding Site 25%
• Pathogenic Variants 25%
• Population Sequencing 25%
• Gene Level 25%
• Level Population 25%
• Residue Interaction 25%
• Pfam Domain 25%
• Ligand Binding Specificity 25%
• Population Variants 25%
• ClinVar 25%
• Nuclear Receptor Ligands 25%
• Pathogenicity Prediction 25%
• Residue Level 25%
• AlphaFold 25%
• Protein Interaction Specificity 25%
• Protein Domain Families 25%
• Residue Level Analysis 25%

Biochemistry, Genetics and Molecular Biology

• Genetic Conservation 100%
• Missense 100%
• Protein Tertiary Structure 100%
• G Protein Coupled Receptor 33%
• Small Molecule 16%
• Molecular Evolution 16%
• Mutagenesis 16%
• Protein-Protein Interaction 16%
• Proteome 16%
• Ligand Binding 16%
• Protein Data Bank 16%
• Protein Ligand 16%
• Sequence Alignment 16%
• Nuclear Receptor 16%
• Ligand Binding Domain 16%