A Xenopus Dbf4 homolog is required for Cdc7 chromatin binding and DNA replication

Pedro Jares, M. Gloria Luciani, J. Julian Blow

    Research output: Contribution to journalArticle

    22 Citations (Scopus)

    Abstract

    Early in the cell cycle a pre-replicative complex (pre-RC) is assembled at each replication origin. This process involves the sequential assembly of the Origin Recognition Complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins onto chromatin to license the origin for use in the subsequent S phase. Licensed origins must then be activated by S phase-inducing cyclin-dependent kinases (S-CDKs) and the Dbf4/Cdc7 kinase.
    Original languageEnglish
    Article number5
    Pages (from-to)1-14
    Number of pages14
    JournalBMC Molecular Biology
    Volume5
    DOIs
    Publication statusPublished - 2004

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