Abdominal paragangliomas: Analysis of surgeon's experience

S.C. FitzGerald, L.M. Gingell, C.N. Parnaby, P.J. O'Dwyer, J.M. Connell

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    Abdominal paraganglioma is a rare endocrine tumor associated with genetic mutations, however, the ability to predict long-term risk of metastasis has not been clarified. The aim of this study was to examine the clinicopathological features and outcomes in patients undergoing surgery for an abdominal paraganglioma. A retrospective analysis was performed for all patients undergoing surgery for abdominal paragangliomas from one surgical department between 1998 and 2010. Clinical presentation, hormone secretion and clinical outcomes were examined. A total of 23 patients underwent surgery for abdominal paraganglioma with the most common presentation being hypertension. Median time to metastasis was 32 months with all patients developing disease progression having a rise in urine catecholamines. Patients with capsular invasion or predisposing genetic conditions are at a higher risk of having more aggressive disease. All patients with a diagnosis of paraganglioma should be screened for predisposing genetic abnormalities and postoperative follow-up must include routine urinary catecholamine assessment.
    Original languageEnglish
    Pages (from-to)55-58
    Number of pages4
    JournalWorld Journal of Endocrine Surgery
    Issue number2
    Publication statusPublished - 1 May 2011

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    FitzGerald, S. C., Gingell, L. M., Parnaby, C. N., O'Dwyer, P. J., & Connell, J. M. (2011). Abdominal paragangliomas: Analysis of surgeon's experience. World Journal of Endocrine Surgery, 3(2), 55-58. https://doi.org/10.5005/jp-journals-10002-1057