Abnormal neural responses to social exclusion in schizophrenia

Victoria B. Gradin, Gordon Waiter, Poornima Kumar, Catriona Stickle, Maarten Milders, Keith Matthews, Ian Reid, Jeremy Hall, J. Douglas Steele

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Abstract

    Social exclusion is an influential concept in politics, mental health and social psychology. Studies on healthy subjects have implicated the medial prefrontal cortex (mPFC), a region involved in emotional and social information processing, in neural responses to social exclusion. Impairments in social interactions are common in schizophrenia and are associated with reduced quality of life. Core symptoms such as delusions usually have a social content. However little is known about the neural underpinnings of social abnormalities. The aim of this study was to investigate the neural substrates of social exclusion in schizophrenia. Patients with schizophrenia and healthy controls underwent fMRI while participating in a popular social exclusion paradigm. This task involves passing a 'ball' between the participant and two cartoon representations of other subjects. The extent of social exclusion (ball not being passed to the participant) was parametrically varied throughout the task. Replicating previous findings, increasing social exclusion activated the mPFC in controls. In contrast, patients with schizophrenia failed to modulate mPFC responses with increasing exclusion. Furthermore, the blunted response to exclusion correlated with increased severity of positive symptoms. These data support the hypothesis that the neural response to social exclusion differs in schizophrenia, highlighting the mPFC as a potential substrate of impaired social interactions.

    Original languageEnglish
    Article numbere42608
    Pages (from-to)-
    Number of pages7
    JournalPLoS ONE
    Volume7
    Issue number8
    DOIs
    Publication statusPublished - 16 Aug 2012

    Keywords

    • Schizophrenia
    • Magnetic Resonance Imaging
    • Neurons
    • Humans
    • Adult
    • Case-Control Studies
    • Middle Aged
    • Social Isolation
    • Male
    • Female

    Cite this

    Gradin, V. B., Waiter, G., Kumar, P., Stickle, C., Milders, M., Matthews, K., Reid, I., Hall, J., & Steele, J. D. (2012). Abnormal neural responses to social exclusion in schizophrenia. PLoS ONE, 7(8), -. [e42608]. https://doi.org/10.1371/journal.pone.0042608