Abnormal Reward Valuation and Event-Related Connectivity in Unmedicated Major Depressive Disorder

Samuel Rupprechter, Aistis Stankevicius, Quentin J. M. Huys, Peggy Seriès, Douglas Steele (Lead / Corresponding author)

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)
    342 Downloads (Pure)


    Background: Experience of emotion is closely linked to valuation. Mood can be viewed as a bias to experience positive or negative emotions and abnormally biased subjective reward valuation and cognitions are core characteristics of major depression.

    Methods: Thirty-four unmedicated subjects with major depressive disorder and controls estimated the probability that fractal stimuli were associated with reward, based on passive observations, so they could subsequently choose the higher of either their estimated fractal value or an explicitly presented reward probability. Using model-based functional magnetic resonance imaging, we estimated each subject's internal value estimation, with psychophysiological interaction analysis used to examine event-related connectivity, testing hypotheses of abnormal reward valuation and cingulate connectivity in depression.

    Results: Reward value encoding in the hippocampus and rostral anterior cingulate was abnormal in depression. In addition, abnormal decision-making in depression was associated with increased anterior mid-cingulate activity and a signal in this region encoded the difference between the values of the two options. This localised decision-making and its impairment to the anterior mid-cingulate cortex (aMCC) consistent with theories of cognitive control. Notably, subjects with depression had significantly decreased event-related connectivity between the aMCC and rostral cingulate regions during decision-making, implying impaired communication between the neural substrates of expected value estimation and decision-making in depression.

    Conclusions: Our findings support the theory that abnormal neural reward valuation plays a central role in major depressive disorder (MDD). To the extent that emotion reflects valuation, abnormal valuation could explain abnormal emotional experience in MDD, reflect a core pathophysiological process and be a target of treatment.

    Original languageEnglish
    Pages (from-to)795-803
    Number of pages9
    JournalPsychological Medicine
    Issue number5
    Early online date7 Jan 2020
    Publication statusPublished - Apr 2021


    • major depressive disorder
    • unmedicated
    • decision-making
    • neural valuation
    • event-related connectivity
    • Decision-making

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Applied Psychology


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