Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases

Naomi Shek; Anna-Maria Choy; Chim C. Lang; Bruce E. Miller; Ruth Tal-Singer; Charlotte E. Bolton; Neil C. Thomson; James D. Chalmers; Matthew J. Bown; David Newby; Faisel Khan; Jeffrey T. J. Huang

doi:10.1038/s41514-024-00143-7

Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases

Naomi Shek, Anna-Maria Choy, Chim C. Lang, Bruce E. Miller, Ruth Tal-Singer, Charlotte E. Bolton, Neil C. Thomson, James D. Chalmers, Matthew J. Bown, David Newby, Faisel Khan, Jeffrey T. J. Huang (Lead / Corresponding author)

Undergraduate Medicine

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

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Abstract

Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.

Original language	English
Article number	15
Number of pages	4
Journal	NPJ Aging and Mechanisms of Disease
Volume	10
DOIs	https://doi.org/10.1038/s41514-024-00143-7
Publication status	Published - 27 Feb 2024

Keywords

accelerated aging
cardiovascular diseases
desosine
elastin degreadation
COPD
abdominal aortic aneurysm
rheumatoid arthritis

ASJC Scopus subject areas

Geriatrics and Gerontology
Ageing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41514-024-00143-7Licence: CC BY

Final published versionFinal published version, 654 KBLicence: CC BY

Cite this

Shek, N., Choy, A.-M., Lang, C. C., Miller, B. E., Tal-Singer, R., Bolton, C. E., Thomson, N. C., Chalmers, J. D., Bown, M. J., Newby, D., Khan, F., & Huang, J. T. J. (2024). Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases. NPJ Aging and Mechanisms of Disease, 10, Article 15. https://doi.org/10.1038/s41514-024-00143-7

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title = "Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases",

abstract = "Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.",

keywords = "accelerated aging, cardiovascular diseases, desosine, elastin degreadation, COPD, abdominal aortic aneurysm, rheumatoid arthritis",

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T2 - a common feature in age-related diseases

AU - Shek, Naomi

AU - Choy, Anna-Maria

AU - Lang, Chim C.

AU - Miller, Bruce E.

AU - Tal-Singer, Ruth

AU - Bolton, Charlotte E.

AU - Thomson, Neil C.

AU - Chalmers, James D.

AU - Bown, Matthew J.

AU - Newby, David

AU - Khan, Faisel

AU - Huang, Jeffrey T. J.

PY - 2024/2/27

Y1 - 2024/2/27

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AB - Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.

KW - accelerated aging

KW - cardiovascular diseases

KW - desosine

KW - elastin degreadation

KW - COPD

KW - abdominal aortic aneurysm

KW - rheumatoid arthritis

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JO - NPJ Aging and Mechanisms of Disease

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M1 - 15

ER -

Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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Isotope Dilution Mass Spectrometry-Based Biomarkers For Management Of Aortic Aneurysm

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Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Projects

Isotope Dilution Mass Spectrometry-Based Biomarkers For Management Of Aortic Aneurysm

Cite this