Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases

Naomi Shek, Anna-Maria Choy, Chim C. Lang, Bruce E. Miller, Ruth Tal-Singer, Charlotte E. Bolton, Neil C. Thomson, James D. Chalmers, Matthew J. Bown, David Newby, Faisel Khan, Jeffrey T. J. Huang (Lead / Corresponding author)

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Abstract

Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.
Original languageEnglish
Article number15
Number of pages4
JournalNPJ Aging and Mechanisms of Disease
Volume10
DOIs
Publication statusPublished - 27 Feb 2024

Keywords

  • accelerated aging
  • cardiovascular diseases
  • desosine
  • elastin degreadation
  • COPD
  • abdominal aortic aneurysm
  • rheumatoid arthritis

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Ageing

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