Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases

Naomi Shek; Anna-Maria Choy; Chim C. Lang; Bruce E. Miller; Ruth Tal-Singer; Charlotte E. Bolton; Neil C. Thomson; James D. Chalmers; Matthew J. Bown; David Newby; Faisel Khan; Jeffrey T. J. Huang

doi:10.1038/s41514-024-00143-7

Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases

Naomi Shek
, Anna-Maria Choy
, Chim C. Lang
, Bruce E. Miller
, Ruth Tal-Singer
, Charlotte E. Bolton
, Neil C. Thomson
, James D. Chalmers
, Matthew J. Bown
, David Newby
, Faisel Khan
, Jeffrey T. J. Huang (Lead / Corresponding author)

Undergraduate Medicine

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

125 Downloads (Pure)

Abstract

Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.

Original language	English
Article number	15
Number of pages	4
Journal	NPJ Aging and Mechanisms of Disease
Volume	10
DOIs	https://doi.org/10.1038/s41514-024-00143-7
Publication status	Published - 27 Feb 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

accelerated aging
cardiovascular diseases
desosine
elastin degreadation
COPD
abdominal aortic aneurysm
rheumatoid arthritis

ASJC Scopus subject areas

Geriatrics and Gerontology
Ageing

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10.1038/s41514-024-00143-7Licence: CC BY

Final published versionFinal published version, 654 KBLicence: CC BY

Cite this

Shek, N., Choy, A.-M., Lang, C. C., Miller, B. E., Tal-Singer, R., Bolton, C. E., Thomson, N. C., Chalmers, J. D., Bown, M. J., Newby, D., Khan, F., & Huang, J. T. J. (2024). Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases. NPJ Aging and Mechanisms of Disease, 10, Article 15. https://doi.org/10.1038/s41514-024-00143-7

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title = "Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases",

abstract = "Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.",

keywords = "accelerated aging, cardiovascular diseases, desosine, elastin degreadation, COPD, abdominal aortic aneurysm, rheumatoid arthritis",

author = "Naomi Shek and Anna-Maria Choy and Lang, \{Chim C.\} and Miller, \{Bruce E.\} and Ruth Tal-Singer and Bolton, \{Charlotte E.\} and Thomson, \{Neil C.\} and Chalmers, \{James D.\} and Bown, \{Matthew J.\} and David Newby and Faisel Khan and Huang, \{Jeffrey T. J.\}",

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doi = "10.1038/s41514-024-00143-7",

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T2 - a common feature in age-related diseases

AU - Shek, Naomi

AU - Choy, Anna-Maria

AU - Lang, Chim C.

AU - Miller, Bruce E.

AU - Tal-Singer, Ruth

AU - Bolton, Charlotte E.

AU - Thomson, Neil C.

AU - Chalmers, James D.

AU - Bown, Matthew J.

AU - Newby, David

AU - Khan, Faisel

AU - Huang, Jeffrey T. J.

PY - 2024/2/27

Y1 - 2024/2/27

N2 - Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.

AB - Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.

KW - accelerated aging

KW - cardiovascular diseases

KW - desosine

KW - elastin degreadation

KW - COPD

KW - abdominal aortic aneurysm

KW - rheumatoid arthritis

UR - https://www.scopus.com/pages/publications/85186193643

U2 - 10.1038/s41514-024-00143-7

DO - 10.1038/s41514-024-00143-7

M3 - Article

C2 - 38413600

SN - 2056-3973

VL - 10

JO - NPJ Aging and Mechanisms of Disease

JF - NPJ Aging and Mechanisms of Disease

M1 - 15

ER -

Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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Isotope Dilution Mass Spectrometry-Based Biomarkers For Management Of Aortic Aneurysm

Cite this

Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Projects

Isotope Dilution Mass Spectrometry-Based Biomarkers For Management Of Aortic Aneurysm

Cite this