Acetylcholine mediated vasodilatation in the microcirculation of patients with chronic fatigue syndrome

V. A. Spence, F. Khan, G. Kennedy, N. C. Abbot, J. J. F. Belch

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    Abstract

    The aetiology of chronic fatigue syndrome (CFS) remains controversial and a number of hypotheses have been put forward to explain it. Research into the condition is hindered by the considerable heterogeneity seen across patients but several reports have highlighted disturbances to cholinergic mechanisms in terms of central nervous system activity, neuromuscular function and autoantibodies to muscarinic cholinergic receptors. This paper examines an altogether separate function for acetylcholine and that is its role as an important and generalized vasodilator. Most diseases are accompanied by a blunted response to acetylcholine but the opposite is true for CFS. Such sensitivity is normally associated with physical training so the finding in CFS is anomalous and may well be relevant to vascular symptoms that characterise many patients. There are several mechanisms that might lead to ACh endothelial sensitivity in CFS patients and various experiments have been designed to unravel the enigma. These are reported here.
    Original languageEnglish
    Pages (from-to)403-407
    Number of pages5
    JournalProstaglandins, Leukotrienes, and Essential Fatty Acids
    Volume70
    Issue number4
    DOIs
    Publication statusPublished - 2004

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    Microcirculation
    Chronic Fatigue Syndrome
    Vasodilation
    Acetylcholine
    Fatigue of materials
    Cholinergic Agents
    Neurology
    Cholinergic Receptors
    Muscarinic Receptors
    Vasodilator Agents
    Autoantibodies
    Blood Vessels
    Central Nervous System
    Research
    Experiments

    Cite this

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    abstract = "The aetiology of chronic fatigue syndrome (CFS) remains controversial and a number of hypotheses have been put forward to explain it. Research into the condition is hindered by the considerable heterogeneity seen across patients but several reports have highlighted disturbances to cholinergic mechanisms in terms of central nervous system activity, neuromuscular function and autoantibodies to muscarinic cholinergic receptors. This paper examines an altogether separate function for acetylcholine and that is its role as an important and generalized vasodilator. Most diseases are accompanied by a blunted response to acetylcholine but the opposite is true for CFS. Such sensitivity is normally associated with physical training so the finding in CFS is anomalous and may well be relevant to vascular symptoms that characterise many patients. There are several mechanisms that might lead to ACh endothelial sensitivity in CFS patients and various experiments have been designed to unravel the enigma. These are reported here.",
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    T1 - Acetylcholine mediated vasodilatation in the microcirculation of patients with chronic fatigue syndrome

    AU - Spence, V. A.

    AU - Khan, F.

    AU - Kennedy, G.

    AU - Abbot, N. C.

    AU - Belch, J. J. F.

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