Acoustic characterization of Thiel liver for magnetic resonance-guided focused ultrasound treatment

Ioannis Karakitsios (Lead / Corresponding author), Joyce Joy, Senay Mihcin, Andreas Melzer

    Research output: Contribution to journalArticle

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    Abstract

    Background: The purpose of this work was to measure the essential acoustic parameters, i.e. acoustic impedance, reflection coefficient, attenuation coefficient, of Thiel embalmed human and animal liver. The Thiel embalmed tissue can be a promising, pre-clinical model to study liver treatment with Magnetic Resonance-guided Focused Ultrasound (MRgFUS).

    Material and methods: Using a single-element transducer and the contact pulse-echo method, the acoustic parameters, i.e. acoustic impedance, reflection coefficient and attenuation coefficient of Thiel embalmed human and animal liver were measured.

    Results: The Thiel embalmed livers had higher impedance, similar reflection and lower attenuation compared to the fresh tissue.

    Conclusions: Embalming liver with Thiel fluid affects its acoustic properties. During MRgFUS sonication of a Thiel organ, more focused ultrasound (FUS) will be backscattered by the organ, and higher acoustic powers are required to reach coagulative levels (temperatures > 56°C).

    Original languageEnglish
    Pages (from-to)92-96
    Number of pages5
    JournalMinimally Invasive Therapy and Allied Technologies
    Volume26
    Issue number2
    Early online date27 Oct 2016
    DOIs
    Publication statusPublished - 2017

    Keywords

    • Acoustic parameters
    • Pre-clinical model
    • Thiel embalming
    • Focused ultrasound ablation

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