Acoustic characterization of Thiel liver for magnetic resonance-guided focused ultrasound treatment

Ioannis Karakitsios; Joyce Joy; Senay Mihcin; Andreas Melzer

doi:10.1080/13645706.2016.1253589

Acoustic characterization of Thiel liver for magnetic resonance-guided focused ultrasound treatment

Ioannis Karakitsios (Lead / Corresponding author), Joyce Joy, Senay Mihcin, Andreas Melzer

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Abstract

Background: The purpose of this work was to measure the essential acoustic parameters, i.e. acoustic impedance, reflection coefficient, attenuation coefficient, of Thiel embalmed human and animal liver. The Thiel embalmed tissue can be a promising, pre-clinical model to study liver treatment with Magnetic Resonance-guided Focused Ultrasound (MRgFUS).

Material and methods: Using a single-element transducer and the contact pulse-echo method, the acoustic parameters, i.e. acoustic impedance, reflection coefficient and attenuation coefficient of Thiel embalmed human and animal liver were measured.

Results: The Thiel embalmed livers had higher impedance, similar reflection and lower attenuation compared to the fresh tissue.

Conclusions: Embalming liver with Thiel fluid affects its acoustic properties. During MRgFUS sonication of a Thiel organ, more focused ultrasound (FUS) will be backscattered by the organ, and higher acoustic powers are required to reach coagulative levels (temperatures > 56°C).

Original language	English
Pages (from-to)	92-96
Number of pages	5
Journal	Minimally Invasive Therapy and Allied Technologies
Volume	26
Issue number	2
Early online date	27 Oct 2016
DOIs	https://doi.org/10.1080/13645706.2016.1253589
Publication status	Published - 2017

Keywords

Acoustic parameters
Pre-clinical model
Thiel embalming
Focused ultrasound ablation

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10.1080/13645706.2016.1253589

Author Accepted ManuscriptAccepted author manuscript, 474 KB

Melzer, Andreas
- Neuroscience - Professor and Director of IMSAT (Teaching and Research)
Person: Academic

Cite this

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title = "Acoustic characterization of Thiel liver for magnetic resonance-guided focused ultrasound treatment",

abstract = "Background: The purpose of this work was to measure the essential acoustic parameters, i.e. acoustic impedance, reflection coefficient, attenuation coefficient, of Thiel embalmed human and animal liver. The Thiel embalmed tissue can be a promising, pre-clinical model to study liver treatment with Magnetic Resonance-guided Focused Ultrasound (MRgFUS).Material and methods: Using a single-element transducer and the contact pulse-echo method, the acoustic parameters, i.e. acoustic impedance, reflection coefficient and attenuation coefficient of Thiel embalmed human and animal liver were measured.Results: The Thiel embalmed livers had higher impedance, similar reflection and lower attenuation compared to the fresh tissue.Conclusions: Embalming liver with Thiel fluid affects its acoustic properties. During MRgFUS sonication of a Thiel organ, more focused ultrasound (FUS) will be backscattered by the organ, and higher acoustic powers are required to reach coagulative levels (temperatures > 56°C).",

keywords = "Acoustic parameters , Pre-clinical model, Thiel embalming , Focused ultrasound ablation",

author = "Ioannis Karakitsios and Joyce Joy and Senay Mihcin and Andreas Melzer",

note = "The authors are thankful for financial assistance provided by from the European Community{\textquoteright}s Seventh Framework Programmes (FP7/2007-2017) and (FP7/2014-2019) under grant agreement numbers 270186 (FUSIMO project) and 611889 (TRANSFUSIMO project).",

year = "2017",

doi = "10.1080/13645706.2016.1253589",

language = "English",

volume = "26",

pages = "92--96",

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issn = "1364-5706",

publisher = "Taylor & Francis",

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T1 - Acoustic characterization of Thiel liver for magnetic resonance-guided focused ultrasound treatment

AU - Karakitsios, Ioannis

AU - Joy, Joyce

AU - Mihcin, Senay

AU - Melzer, Andreas

N1 - The authors are thankful for financial assistance provided by from the European Community’s Seventh Framework Programmes (FP7/2007-2017) and (FP7/2014-2019) under grant agreement numbers 270186 (FUSIMO project) and 611889 (TRANSFUSIMO project).

PY - 2017

Y1 - 2017

N2 - Background: The purpose of this work was to measure the essential acoustic parameters, i.e. acoustic impedance, reflection coefficient, attenuation coefficient, of Thiel embalmed human and animal liver. The Thiel embalmed tissue can be a promising, pre-clinical model to study liver treatment with Magnetic Resonance-guided Focused Ultrasound (MRgFUS).Material and methods: Using a single-element transducer and the contact pulse-echo method, the acoustic parameters, i.e. acoustic impedance, reflection coefficient and attenuation coefficient of Thiel embalmed human and animal liver were measured.Results: The Thiel embalmed livers had higher impedance, similar reflection and lower attenuation compared to the fresh tissue.Conclusions: Embalming liver with Thiel fluid affects its acoustic properties. During MRgFUS sonication of a Thiel organ, more focused ultrasound (FUS) will be backscattered by the organ, and higher acoustic powers are required to reach coagulative levels (temperatures > 56°C).

AB - Background: The purpose of this work was to measure the essential acoustic parameters, i.e. acoustic impedance, reflection coefficient, attenuation coefficient, of Thiel embalmed human and animal liver. The Thiel embalmed tissue can be a promising, pre-clinical model to study liver treatment with Magnetic Resonance-guided Focused Ultrasound (MRgFUS).Material and methods: Using a single-element transducer and the contact pulse-echo method, the acoustic parameters, i.e. acoustic impedance, reflection coefficient and attenuation coefficient of Thiel embalmed human and animal liver were measured.Results: The Thiel embalmed livers had higher impedance, similar reflection and lower attenuation compared to the fresh tissue.Conclusions: Embalming liver with Thiel fluid affects its acoustic properties. During MRgFUS sonication of a Thiel organ, more focused ultrasound (FUS) will be backscattered by the organ, and higher acoustic powers are required to reach coagulative levels (temperatures > 56°C).

KW - Acoustic parameters

KW - Pre-clinical model

KW - Thiel embalming

KW - Focused ultrasound ablation

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DO - 10.1080/13645706.2016.1253589

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SN - 1364-5706

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JO - Minimally Invasive Therapy and Allied Technologies

JF - Minimally Invasive Therapy and Allied Technologies

IS - 2

ER -

Acoustic characterization of Thiel liver for magnetic resonance-guided focused ultrasound treatment

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Melzer, Andreas

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