Acoustic devices for particle and cell manipulation and sensing

Yongqiang Qiu, Han Wang, Christine E. M. Demore, David A. Hughes, Peter Glynne-Jones, Sylvia Gebhardt, Aleksandrs Bolhovitins, Romans Poltarjonoks, Kees Weijer, Andreas Schönecker, Martyn Hill, Sandy Cochran (Lead / Corresponding author)

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    Abstract

    An emerging demand for the precise manipulation of cells and particles for applications in cell biology and analytical chemistry has driven rapid development of ultrasonic manipulation technology. Compared to the other manipulation technologies, such as magnetic tweezing, dielectrophoresis and optical tweezing, ultrasonic manipulation has shown potential in a variety of applications, with its advantages of versatile, inexpensive and easy integration into microfluidic systems, maintenance of cell viability, and generation of sufficient forces to handle particles, cells and their agglomerates. This article briefly reviews current practice and reports our development of various ultrasonic standing wave manipulation devices, including simple devices integrated with high frequency (>20 MHz) ultrasonic transducers for the investigation of biological cells and complex ultrasonic transducer array systems to explore the feasibility of electronically controlled 2-D and 3-D manipulation. Piezoelectric and passive materials, fabrication techniques, characterization methods and possible applications are discussed. The behavior and performance of the devices have been investigated and predicted with computer simulations, and verified experimentally. Issues met during development are highlighted and discussed. To assist long term practical adoption, approaches to low-cost, wafer level batch-production and commercialization potential are also addressed.
    Original languageEnglish
    Pages (from-to)14806-14838
    Number of pages33
    JournalSensors
    Volume14
    Issue number8
    DOIs
    Publication statusPublished - 2014

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    Acoustic devices
    Acoustics
    Ultrasonics
    manipulators
    Ultrasonic transducers
    ultrasonics
    Equipment and Supplies
    acoustics
    cells
    Transducers
    Cytology
    Technology
    Electrophoresis
    Microfluidics
    transducers
    Cells
    Computer Simulation
    analytical chemistry
    Cell Biology
    Fabrication

    Cite this

    Qiu, Y., Wang, H., Demore, C. E. M., Hughes, D. A., Glynne-Jones, P., Gebhardt, S., ... Cochran, S. (2014). Acoustic devices for particle and cell manipulation and sensing. Sensors, 14(8), 14806-14838. https://doi.org/10.3390/s140814806
    Qiu, Yongqiang ; Wang, Han ; Demore, Christine E. M. ; Hughes, David A. ; Glynne-Jones, Peter ; Gebhardt, Sylvia ; Bolhovitins, Aleksandrs ; Poltarjonoks, Romans ; Weijer, Kees ; Schönecker, Andreas ; Hill, Martyn ; Cochran, Sandy. / Acoustic devices for particle and cell manipulation and sensing. In: Sensors. 2014 ; Vol. 14, No. 8. pp. 14806-14838.
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    abstract = "An emerging demand for the precise manipulation of cells and particles for applications in cell biology and analytical chemistry has driven rapid development of ultrasonic manipulation technology. Compared to the other manipulation technologies, such as magnetic tweezing, dielectrophoresis and optical tweezing, ultrasonic manipulation has shown potential in a variety of applications, with its advantages of versatile, inexpensive and easy integration into microfluidic systems, maintenance of cell viability, and generation of sufficient forces to handle particles, cells and their agglomerates. This article briefly reviews current practice and reports our development of various ultrasonic standing wave manipulation devices, including simple devices integrated with high frequency (>20 MHz) ultrasonic transducers for the investigation of biological cells and complex ultrasonic transducer array systems to explore the feasibility of electronically controlled 2-D and 3-D manipulation. Piezoelectric and passive materials, fabrication techniques, characterization methods and possible applications are discussed. The behavior and performance of the devices have been investigated and predicted with computer simulations, and verified experimentally. Issues met during development are highlighted and discussed. To assist long term practical adoption, approaches to low-cost, wafer level batch-production and commercialization potential are also addressed.",
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    Qiu, Y, Wang, H, Demore, CEM, Hughes, DA, Glynne-Jones, P, Gebhardt, S, Bolhovitins, A, Poltarjonoks, R, Weijer, K, Schönecker, A, Hill, M & Cochran, S 2014, 'Acoustic devices for particle and cell manipulation and sensing', Sensors, vol. 14, no. 8, pp. 14806-14838. https://doi.org/10.3390/s140814806

    Acoustic devices for particle and cell manipulation and sensing. / Qiu, Yongqiang; Wang, Han; Demore, Christine E. M.; Hughes, David A.; Glynne-Jones, Peter; Gebhardt, Sylvia; Bolhovitins, Aleksandrs; Poltarjonoks, Romans; Weijer, Kees; Schönecker, Andreas; Hill, Martyn; Cochran, Sandy (Lead / Corresponding author).

    In: Sensors, Vol. 14, No. 8, 2014, p. 14806-14838.

    Research output: Contribution to journalArticle

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    Qiu Y, Wang H, Demore CEM, Hughes DA, Glynne-Jones P, Gebhardt S et al. Acoustic devices for particle and cell manipulation and sensing. Sensors. 2014;14(8):14806-14838. https://doi.org/10.3390/s140814806