Actin dynamics in protein homeostasis

Thomas David Williams (Lead / Corresponding author), Adrien Rousseau

Research output: Contribution to journalReview articlepeer-review

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Abstract

Cell homeostasis is maintained in all organisms by the constant adjustment of cell constituents and organisation to account for environmental context. Fine-tuning of the optimal balance of proteins for the conditions, or protein homeostasis, is critical to maintaining cell homeostasis. Actin, a major constituent of the cytoskeleton, forms many different structures which are acutely sensitive to the cell environment. Furthermore, actin structures interact with and are critically important for the function and regulation of multiple factors involved with mRNA and protein production and degradation, and protein regulation. Altogether, actin is a key, if often overlooked, regulator of protein homeostasis across eukaryotes. In this review, we highlight these roles and how they are altered following cell stress, from mRNA transcription to protein degradation.

Original languageEnglish
Article numberBSR20210848
Number of pages19
JournalBioscience Reports
Volume42
Issue number9
Early online date31 Aug 2022
DOIs
Publication statusPublished - 12 Sep 2022

Keywords

  • Actin
  • Cell stress
  • proteostasis
  • protein homeostasis
  • protein regulation

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