Activated factor XII in rheumatoid arthritis

Margaret McLaren, J. Alkaabi, M. Connacher, J. J. F. Belch, E. Valenete

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Abstract

    Rheumatoid arthritis (RA) is associated with premature mortality, with approximately 50% of deaths being due to cardiovascular disease. It has been shown that the increased incidence of cardiovascular disease is independent of traditional risk factors. Previous studies have shown an increased risk of coronary heart disease with increased levels of activated factor XII (FXIIa). The aim of this study was to investigate levels of FXIIa in patients with RA. We studied 32 patients with RA and 30 age- and sex-matched control subjects. We found FXIIa levels significantly increased in the patient group, with 56% of the patients and 6.7% of controls having levels greater than or equal to 2 ng/ml. A previous study has shown that individuals with levels of 2 ng/ml or more have an increased risk of coronary heart disease. Measurement of FXIIa could perhaps help to identify an 'at risk' group of patients, allowing early intervention therapy.
    Original languageEnglish
    Pages (from-to)182-184
    Number of pages3
    JournalRheumatology international
    Volume22
    Issue number5
    DOIs
    Publication statusPublished - Sep 2002

    Fingerprint

    Factor XIIa
    Rheumatoid Arthritis
    Coronary Disease
    Cardiovascular Diseases
    Premature Mortality
    Secondary Prevention
    Incidence

    Cite this

    McLaren, Margaret ; Alkaabi, J. ; Connacher, M. ; Belch, J. J. F. ; Valenete, E. / Activated factor XII in rheumatoid arthritis. In: Rheumatology international. 2002 ; Vol. 22, No. 5. pp. 182-184.
    @article{5ae6eac573334ae3bc8fac7a6891a9cd,
    title = "Activated factor XII in rheumatoid arthritis",
    abstract = "Rheumatoid arthritis (RA) is associated with premature mortality, with approximately 50{\%} of deaths being due to cardiovascular disease. It has been shown that the increased incidence of cardiovascular disease is independent of traditional risk factors. Previous studies have shown an increased risk of coronary heart disease with increased levels of activated factor XII (FXIIa). The aim of this study was to investigate levels of FXIIa in patients with RA. We studied 32 patients with RA and 30 age- and sex-matched control subjects. We found FXIIa levels significantly increased in the patient group, with 56{\%} of the patients and 6.7{\%} of controls having levels greater than or equal to 2 ng/ml. A previous study has shown that individuals with levels of 2 ng/ml or more have an increased risk of coronary heart disease. Measurement of FXIIa could perhaps help to identify an 'at risk' group of patients, allowing early intervention therapy.",
    author = "Margaret McLaren and J. Alkaabi and M. Connacher and Belch, {J. J. F.} and E. Valenete",
    year = "2002",
    month = "9",
    doi = "10.1007/s00296-002-0219-6",
    language = "English",
    volume = "22",
    pages = "182--184",
    journal = "Rheumatology international",
    issn = "0172-8172",
    publisher = "Springer Verlag",
    number = "5",

    }

    McLaren, M, Alkaabi, J, Connacher, M, Belch, JJF & Valenete, E 2002, 'Activated factor XII in rheumatoid arthritis', Rheumatology international, vol. 22, no. 5, pp. 182-184. https://doi.org/10.1007/s00296-002-0219-6

    Activated factor XII in rheumatoid arthritis. / McLaren, Margaret; Alkaabi, J.; Connacher, M.; Belch, J. J. F.; Valenete, E.

    In: Rheumatology international, Vol. 22, No. 5, 09.2002, p. 182-184.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Activated factor XII in rheumatoid arthritis

    AU - McLaren, Margaret

    AU - Alkaabi, J.

    AU - Connacher, M.

    AU - Belch, J. J. F.

    AU - Valenete, E.

    PY - 2002/9

    Y1 - 2002/9

    N2 - Rheumatoid arthritis (RA) is associated with premature mortality, with approximately 50% of deaths being due to cardiovascular disease. It has been shown that the increased incidence of cardiovascular disease is independent of traditional risk factors. Previous studies have shown an increased risk of coronary heart disease with increased levels of activated factor XII (FXIIa). The aim of this study was to investigate levels of FXIIa in patients with RA. We studied 32 patients with RA and 30 age- and sex-matched control subjects. We found FXIIa levels significantly increased in the patient group, with 56% of the patients and 6.7% of controls having levels greater than or equal to 2 ng/ml. A previous study has shown that individuals with levels of 2 ng/ml or more have an increased risk of coronary heart disease. Measurement of FXIIa could perhaps help to identify an 'at risk' group of patients, allowing early intervention therapy.

    AB - Rheumatoid arthritis (RA) is associated with premature mortality, with approximately 50% of deaths being due to cardiovascular disease. It has been shown that the increased incidence of cardiovascular disease is independent of traditional risk factors. Previous studies have shown an increased risk of coronary heart disease with increased levels of activated factor XII (FXIIa). The aim of this study was to investigate levels of FXIIa in patients with RA. We studied 32 patients with RA and 30 age- and sex-matched control subjects. We found FXIIa levels significantly increased in the patient group, with 56% of the patients and 6.7% of controls having levels greater than or equal to 2 ng/ml. A previous study has shown that individuals with levels of 2 ng/ml or more have an increased risk of coronary heart disease. Measurement of FXIIa could perhaps help to identify an 'at risk' group of patients, allowing early intervention therapy.

    U2 - 10.1007/s00296-002-0219-6

    DO - 10.1007/s00296-002-0219-6

    M3 - Article

    VL - 22

    SP - 182

    EP - 184

    JO - Rheumatology international

    JF - Rheumatology international

    SN - 0172-8172

    IS - 5

    ER -