Activated factor XII in rheumatoid arthritis

Margaret McLaren; J. Alkaabi; M. Connacher; J. J. F. Belch; E. Valenete

doi:10.1007/s00296-002-0219-6

Activated factor XII in rheumatoid arthritis

Margaret McLaren, J. Alkaabi, M. Connacher, J. J. F. Belch, E. Valenete

Research output: Contribution to journal › Article › peer-review

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Abstract

Rheumatoid arthritis (RA) is associated with premature mortality, with approximately 50% of deaths being due to cardiovascular disease. It has been shown that the increased incidence of cardiovascular disease is independent of traditional risk factors. Previous studies have shown an increased risk of coronary heart disease with increased levels of activated factor XII (FXIIa). The aim of this study was to investigate levels of FXIIa in patients with RA. We studied 32 patients with RA and 30 age- and sex-matched control subjects. We found FXIIa levels significantly increased in the patient group, with 56% of the patients and 6.7% of controls having levels greater than or equal to 2 ng/ml. A previous study has shown that individuals with levels of 2 ng/ml or more have an increased risk of coronary heart disease. Measurement of FXIIa could perhaps help to identify an 'at risk' group of patients, allowing early intervention therapy.

Original language	English
Pages (from-to)	182-184
Number of pages	3
Journal	Rheumatology international
Volume	22
Issue number	5
DOIs	https://doi.org/10.1007/s00296-002-0219-6
Publication status	Published - Sept 2002

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title = "Activated factor XII in rheumatoid arthritis",

abstract = "Rheumatoid arthritis (RA) is associated with premature mortality, with approximately 50% of deaths being due to cardiovascular disease. It has been shown that the increased incidence of cardiovascular disease is independent of traditional risk factors. Previous studies have shown an increased risk of coronary heart disease with increased levels of activated factor XII (FXIIa). The aim of this study was to investigate levels of FXIIa in patients with RA. We studied 32 patients with RA and 30 age- and sex-matched control subjects. We found FXIIa levels significantly increased in the patient group, with 56% of the patients and 6.7% of controls having levels greater than or equal to 2 ng/ml. A previous study has shown that individuals with levels of 2 ng/ml or more have an increased risk of coronary heart disease. Measurement of FXIIa could perhaps help to identify an 'at risk' group of patients, allowing early intervention therapy.",

author = "Margaret McLaren and J. Alkaabi and M. Connacher and Belch, {J. J. F.} and E. Valenete",

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doi = "10.1007/s00296-002-0219-6",

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T1 - Activated factor XII in rheumatoid arthritis

AU - McLaren, Margaret

AU - Alkaabi, J.

AU - Connacher, M.

AU - Belch, J. J. F.

AU - Valenete, E.

PY - 2002/9

Y1 - 2002/9

N2 - Rheumatoid arthritis (RA) is associated with premature mortality, with approximately 50% of deaths being due to cardiovascular disease. It has been shown that the increased incidence of cardiovascular disease is independent of traditional risk factors. Previous studies have shown an increased risk of coronary heart disease with increased levels of activated factor XII (FXIIa). The aim of this study was to investigate levels of FXIIa in patients with RA. We studied 32 patients with RA and 30 age- and sex-matched control subjects. We found FXIIa levels significantly increased in the patient group, with 56% of the patients and 6.7% of controls having levels greater than or equal to 2 ng/ml. A previous study has shown that individuals with levels of 2 ng/ml or more have an increased risk of coronary heart disease. Measurement of FXIIa could perhaps help to identify an 'at risk' group of patients, allowing early intervention therapy.

AB - Rheumatoid arthritis (RA) is associated with premature mortality, with approximately 50% of deaths being due to cardiovascular disease. It has been shown that the increased incidence of cardiovascular disease is independent of traditional risk factors. Previous studies have shown an increased risk of coronary heart disease with increased levels of activated factor XII (FXIIa). The aim of this study was to investigate levels of FXIIa in patients with RA. We studied 32 patients with RA and 30 age- and sex-matched control subjects. We found FXIIa levels significantly increased in the patient group, with 56% of the patients and 6.7% of controls having levels greater than or equal to 2 ng/ml. A previous study has shown that individuals with levels of 2 ng/ml or more have an increased risk of coronary heart disease. Measurement of FXIIa could perhaps help to identify an 'at risk' group of patients, allowing early intervention therapy.

U2 - 10.1007/s00296-002-0219-6

DO - 10.1007/s00296-002-0219-6

M3 - Article

C2 - 12215862

SN - 0172-8172

VL - 22

SP - 182

EP - 184

JO - Rheumatology international

JF - Rheumatology international

IS - 5

ER -

Activated factor XII in rheumatoid arthritis

Abstract

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