Activation of BKCa channels in acutely dissociated neurones from the rat ventromedial hypothalamus by NS 1619

A. J. Sellers; M. L. Ashford

Activation of BKCa channels in acutely dissociated neurones from the rat ventromedial hypothalamus by NS 1619

Research output: Contribution to journal › Article › peer-review

Abstract

NS 1619 activates the large-conductance Ca(2+)-dependent K+ channel (BKCa) in membrane patches isolated from rat ventromedial hypothalamic neurones. The activation is concentration dependent, with a maximal effect at less than 30 microM, reversible and can be inhibited by application of iberiotoxin to the extracellular membrane. NS 1619 does not activate ATP-K+ channels present in the same neurones.

Original language	English
Pages (from-to)	659-661
Number of pages	3
Journal	British Journal of Pharmacology
Volume	113
Issue number	3
Publication status	Published - Nov 1994

Keywords

Rats
Benzimidazoles
Animals
Calcium
Ventromedial Hypothalamic Nucleus
Cells, Cultured
Peptides
Potassium Channels

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1510436/

Cite this

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title = "Activation of BKCa channels in acutely dissociated neurones from the rat ventromedial hypothalamus by NS 1619",

abstract = "NS 1619 activates the large-conductance Ca(2+)-dependent K+ channel (BKCa) in membrane patches isolated from rat ventromedial hypothalamic neurones. The activation is concentration dependent, with a maximal effect at less than 30 microM, reversible and can be inhibited by application of iberiotoxin to the extracellular membrane. NS 1619 does not activate ATP-K+ channels present in the same neurones.",

keywords = "Rats, Benzimidazoles, Animals, Calcium, Ventromedial Hypothalamic Nucleus, Cells, Cultured, Peptides, Potassium Channels",

author = "Sellers, {A. J.} and Ashford, {M. L.}",

year = "1994",

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journal = "British Journal of Pharmacology",

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AU - Sellers, A. J.

AU - Ashford, M. L.

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N2 - NS 1619 activates the large-conductance Ca(2+)-dependent K+ channel (BKCa) in membrane patches isolated from rat ventromedial hypothalamic neurones. The activation is concentration dependent, with a maximal effect at less than 30 microM, reversible and can be inhibited by application of iberiotoxin to the extracellular membrane. NS 1619 does not activate ATP-K+ channels present in the same neurones.

AB - NS 1619 activates the large-conductance Ca(2+)-dependent K+ channel (BKCa) in membrane patches isolated from rat ventromedial hypothalamic neurones. The activation is concentration dependent, with a maximal effect at less than 30 microM, reversible and can be inhibited by application of iberiotoxin to the extracellular membrane. NS 1619 does not activate ATP-K+ channels present in the same neurones.

KW - Rats

KW - Benzimidazoles

KW - Animals

KW - Calcium

KW - Ventromedial Hypothalamic Nucleus

KW - Cells, Cultured

KW - Peptides

KW - Potassium Channels

M3 - Article

C2 - 7858852

SN - 0007-1188

VL - 113

SP - 659

EP - 661

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 3

ER -

Activation of BKCa channels in acutely dissociated neurones from the rat ventromedial hypothalamus by NS 1619

Abstract

Keywords

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