Activation of BKCa channels in acutely dissociated neurones from the rat ventromedial hypothalamus by NS 1619

A. J. Sellers, M. L. Ashford

    Research output: Contribution to journalArticle

    33 Citations (Scopus)

    Abstract

    NS 1619 activates the large-conductance Ca(2+)-dependent K+ channel (BKCa) in membrane patches isolated from rat ventromedial hypothalamic neurones. The activation is concentration dependent, with a maximal effect at less than 30 microM, reversible and can be inhibited by application of iberiotoxin to the extracellular membrane. NS 1619 does not activate ATP-K+ channels present in the same neurones.
    Original languageEnglish
    Pages (from-to)659-661
    Number of pages3
    JournalBritish Journal of Pharmacology
    Volume113
    Issue number3
    Publication statusPublished - Nov 1994

    Keywords

    • Rats
    • Benzimidazoles
    • Animals
    • Calcium
    • Ventromedial Hypothalamic Nucleus
    • Cells, Cultured
    • Peptides
    • Potassium Channels

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