NS 1619 activates the large-conductance Ca(2+)-dependent K+ channel (BKCa) in membrane patches isolated from rat ventromedial hypothalamic neurones. The activation is concentration dependent, with a maximal effect at less than 30 microM, reversible and can be inhibited by application of iberiotoxin to the extracellular membrane. NS 1619 does not activate ATP-K+ channels present in the same neurones.
|Number of pages||3|
|Journal||British Journal of Pharmacology|
|Publication status||Published - Nov 1994|
- Ventromedial Hypothalamic Nucleus
- Cells, Cultured
- Potassium Channels