Abstract
The pharmacology of the metabotropic glutamate receptor (mGluR)-mediated potentiation of N-methyl-D-aspartate (NMDA)evoked depolarisations in the CA1 region of rat hippocampal slices was investigated using an extracellular grease-gap method. The group I and II mGluR agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3R)-ACPD; 10 μM) potentiated responses to NMDA (15-25 μM), giving a dose ratio of 0.84 ± 0.02. The mGluR group I specific agonist (RS3,5-dihydroxyphenylglycine (DHPG) (3-10 μM) also induced a dose-dependent and reversible enhancement of responses to NMDA (dose ratio for 10 μM DHPG was 0.77 ± 0.02). In contrast, the group II selective agonist (2S,1'R,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (DCG-IV; 0.5-1 μM) and the group III specific agonist (S)-2-amino-4-phosphonobutanoate (L-AP4; 50 μM) caused little or no potentiation of responses to NMDA. The potentiation induced by 3-5 μM DHPG was reversibly antagonised by the group I and II antagonist (+)-α-methyl-4-carboxyphenylglycine ((+)-MCPG; 1 mM). The present findings demonstrate that activation of group I mGluRs enhance NMDA responses in the hippocampus.
Original language | English |
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Pages (from-to) | 211-213 |
Number of pages | 3 |
Journal | Neuroscience Letters |
Volume | 203 |
Issue number | 3 |
DOIs | |
Publication status | Published - 26 Jan 1996 |
Keywords
- (RS)-3,5-Dihydroxyphenylglycine
- Glutamate
- Hippocampus
- Metabotropic glutamate receptor
- N-Methyl-D-aspartate
ASJC Scopus subject areas
- General Neuroscience