Activation of protein kinase C modulates the expression of the T3/T cell antigen receptor complex on human T lymphocytes

Adelina A. Davies; Doreen A. Cantrell; Michael J. Crumpton

doi:10.1007/BF01119898

Activation of protein kinase C modulates the expression of the T3/T cell antigen receptor complex on human T lymphocytes

Adelina A. Davies, Doreen A. Cantrell, Michael J. Crumpton

Cell Signalling and Immunology

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Activators of protein kinase C induced a rapid decrease (within 15 min) in the surface expression of the T3 antigen and T-lymphocyte antigen receptor (Ti) on HPB-ALL cells, and a concomitant phosphorylation of the T3 γ and δ polypeptides; the γ chain was more extensively phosphorylated than the δ chain. No phosphorylation of the T3 ∈ chain and the Ti α and β polypeptides was detected. Evidence was obtained that the T3 γ chain is phosphorylated only on serine residues.

Original language	English
Pages (from-to)	867-876
Number of pages	10
Journal	Bioscience Reports
Volume	5
Issue number	10-11
DOIs	https://doi.org/10.1007/BF01119898
Publication status	Published - 1 Oct 1985

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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abstract = "Activators of protein kinase C induced a rapid decrease (within 15 min) in the surface expression of the T3 antigen and T-lymphocyte antigen receptor (Ti) on HPB-ALL cells, and a concomitant phosphorylation of the T3 γ and δ polypeptides; the γ chain was more extensively phosphorylated than the δ chain. No phosphorylation of the T3 ∈ chain and the Ti α and β polypeptides was detected. Evidence was obtained that the T3 γ chain is phosphorylated only on serine residues.",

author = "Davies, {Adelina A.} and Cantrell, {Doreen A.} and Crumpton, {Michael J.}",

year = "1985",

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AU - Davies, Adelina A.

AU - Cantrell, Doreen A.

AU - Crumpton, Michael J.

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Y1 - 1985/10/1

N2 - Activators of protein kinase C induced a rapid decrease (within 15 min) in the surface expression of the T3 antigen and T-lymphocyte antigen receptor (Ti) on HPB-ALL cells, and a concomitant phosphorylation of the T3 γ and δ polypeptides; the γ chain was more extensively phosphorylated than the δ chain. No phosphorylation of the T3 ∈ chain and the Ti α and β polypeptides was detected. Evidence was obtained that the T3 γ chain is phosphorylated only on serine residues.

AB - Activators of protein kinase C induced a rapid decrease (within 15 min) in the surface expression of the T3 antigen and T-lymphocyte antigen receptor (Ti) on HPB-ALL cells, and a concomitant phosphorylation of the T3 γ and δ polypeptides; the γ chain was more extensively phosphorylated than the δ chain. No phosphorylation of the T3 ∈ chain and the Ti α and β polypeptides was detected. Evidence was obtained that the T3 γ chain is phosphorylated only on serine residues.

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Activation of protein kinase C modulates the expression of the T3/T cell antigen receptor complex on human T lymphocytes

Abstract

ASJC Scopus subject areas

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