Activation of protein kinase C modulates the expression of the T3/T cell antigen receptor complex on human T lymphocytes

TY - JOUR

T1 - Activation of protein kinase C modulates the expression of the T3/T cell antigen receptor complex on human T lymphocytes

AU - Davies, Adelina A.

AU - Cantrell, Doreen A.

AU - Crumpton, Michael J.

PY - 1985/10/1

Y1 - 1985/10/1

N2 - Activators of protein kinase C induced a rapid decrease (within 15 min) in the surface expression of the T3 antigen and T-lymphocyte antigen receptor (Ti) on HPB-ALL cells, and a concomitant phosphorylation of the T3 γ and δ polypeptides; the γ chain was more extensively phosphorylated than the δ chain. No phosphorylation of the T3 ∈ chain and the Ti α and β polypeptides was detected. Evidence was obtained that the T3 γ chain is phosphorylated only on serine residues.

AB - Activators of protein kinase C induced a rapid decrease (within 15 min) in the surface expression of the T3 antigen and T-lymphocyte antigen receptor (Ti) on HPB-ALL cells, and a concomitant phosphorylation of the T3 γ and δ polypeptides; the γ chain was more extensively phosphorylated than the δ chain. No phosphorylation of the T3 ∈ chain and the Ti α and β polypeptides was detected. Evidence was obtained that the T3 γ chain is phosphorylated only on serine residues.

UR - https://www.scopus.com/pages/publications/0022313315

U2 - 10.1007/BF01119898

DO - 10.1007/BF01119898

M3 - Article

C2 - 3879456

AN - SCOPUS:0022313315

SN - 0144-8463

VL - 5

SP - 867

EP - 876

JO - Bioscience Reports

JF - Bioscience Reports

IS - 10-11

ER -