Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells

Yair N. Doza, Ana Cuenda, Gareth M. Thomas, Philip Cohen, Angel R. Nebreda

    Research output: Contribution to journalArticle

    69 Citations (Scopus)

    Abstract

    A MAP kinase homologue, termed the reactivating kinase (RK), lies in a signalling pathway which mediates cellular responses to stress. Here we demonstrate that the stress-induced activation of the RK in human KB cells is accompanied by the phosphorylation of Thr-180 and Tyr-182, and that the phosphorylation of both residues is required for the activation of this enzyme.

    Original languageEnglish
    Pages (from-to)223-228
    Number of pages6
    JournalFEBS Letters
    Volume364
    Issue number2
    DOIs
    Publication statusPublished - 8 May 1995

    Keywords

    • Arsenite
    • MAP kinase
    • Phosphotyrosine
    • Protein kinase
    • Stress

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