Acute effects of atrial natriuretic peptide on left ventricular diastolic function: A pulsed wave Doppler study in man

P. B. M. Clarkson, N. M. Wheeldon, C. Macleod, W. Coutie, T. M. MacDonald

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14 Citations (Scopus)

Abstract

Doppler echocardiographic indices of diastolic function and systemic haemodynamics were studied in response to infusions of atrial natriuretic peptide (0.5, 1, 2, 5 pmol.kg-1.min-1) and placebo (0.9% (w/v) saline) in ten normal male subjects. Compared with placebo, atrial natriuretic peptide infusion produced a significant and dose-related reduction in the isovolumic relaxation time [(mean and 95% CI) - 59 (- 9.2 to - 2.6) ins (P<0.01) at 5pg.kg-1 min-1] and a significant increase in the ratio between early and late transmitral peak velocities [0.46 (0.02 to 0.89) (P<0.05) at 5 pg.kg-1 mn-1]. No significant changes in heart rate, blood pressure or aortic stroke distance were observed with infusion of atrial natriuretic peptide compared with placebo. These data suggest that pathophyisological plasma concentrations of atrial natriuretic peptide improve diastolic function by increasing the rate of myocardial relaxation.

Original languageEnglish
Pages (from-to)1710-1715
Number of pages6
JournalEuropean Heart Journal
Volume16
Issue number11
DOIs
Publication statusPublished - 1 Nov 1995

Keywords

  • Atrial natriuretic peptide
  • Diastolic function
  • Left ventricle

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