Acute neuropsychological effects of methylphenidate in stimulant drug-naive boys with ADHD II - broader executive and non-executive domains

Sinead M. Rhodes, David R. Coghill, Keith Matthews

    Research output: Contribution to journalArticle

    80 Citations (Scopus)

    Abstract

    Background: Accumulating evidence supports methylphenidate-induced enhancement of neuropsychological functioning in attention deficit hyperactivity disorder (ADHD). The present study was designed to investigate the acute effects of the psychostimulant drug, methylphenidate (MPH), on neuropsychological performance in stimulant naïve boys with ADHD. Methods: Seventy-three drug-naïve boys (age 7–15) with ADHD (combined type) completed neuropsychological tasks from the CANTAB battery under randomised, placebo controlled, double-blind conditions following an acute challenge with either placebo (n = 24), .3 (n = 25) or .6 (n = 24) mg/kg oral MPH. Results: MPH did not impair performance on any task. MPH (.6 mg/kg) lengthened response latencies on a task of Spatial Recognition, shortened response times on a Reaction Time task and restored performance on a Delayed Matching to Sample visual, non-working memory task. Contrary to predictions, MPH did not enhance performance on tasks with a prominent executive component, including Go/NoGo, Spatial Working Memory, Stockings of Cambridge and Attentional Set shifting tasks. Conclusions: Acute administration of MPH to drug-naïve boys with ADHD did not impair neuropsychological performance. Acute MPH enhanced performance on some aspects of non-executive functioning. MPH-induced slowing of responding on a relatively complex Spatial Recognition memory task and quickened responding on a reaction time task requiring less cognitive resources suggests that MPH may act by improving self-regulatory ability. MPH may not exert its effects on neuropsychological functioning by enhancing executive processes.
    Original languageEnglish
    Pages (from-to)1184-1194
    Number of pages11
    JournalJournal of Child Psychology and Psychiatry
    Volume47
    Issue number11
    DOIs
    Publication statusPublished - 2006

    Fingerprint

    Methylphenidate
    Attention Deficit Disorder with Hyperactivity
    Pharmaceutical Preparations
    Reaction Time
    Task Performance and Analysis
    Placebos
    Aptitude
    Short-Term Memory

    Keywords

    • Adolescent
    • Attention
    • Attention Deficit Disorder with Hyperactivity
    • Central Nervous System Stimulants
    • Child
    • Double-Blind Method
    • Humans
    • Internal-External Control
    • Male
    • Mental Recall
    • Methylphenidate
    • Neuropsychological Tests
    • Orientation
    • Pattern Recognition, Visual
    • Problem Solving
    • Reaction Time

    Cite this

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    title = "Acute neuropsychological effects of methylphenidate in stimulant drug-naive boys with ADHD II - broader executive and non-executive domains",
    abstract = "Background: Accumulating evidence supports methylphenidate-induced enhancement of neuropsychological functioning in attention deficit hyperactivity disorder (ADHD). The present study was designed to investigate the acute effects of the psychostimulant drug, methylphenidate (MPH), on neuropsychological performance in stimulant na{\"i}ve boys with ADHD. Methods: Seventy-three drug-na{\"i}ve boys (age 7–15) with ADHD (combined type) completed neuropsychological tasks from the CANTAB battery under randomised, placebo controlled, double-blind conditions following an acute challenge with either placebo (n = 24), .3 (n = 25) or .6 (n = 24) mg/kg oral MPH. Results: MPH did not impair performance on any task. MPH (.6 mg/kg) lengthened response latencies on a task of Spatial Recognition, shortened response times on a Reaction Time task and restored performance on a Delayed Matching to Sample visual, non-working memory task. Contrary to predictions, MPH did not enhance performance on tasks with a prominent executive component, including Go/NoGo, Spatial Working Memory, Stockings of Cambridge and Attentional Set shifting tasks. Conclusions: Acute administration of MPH to drug-na{\"i}ve boys with ADHD did not impair neuropsychological performance. Acute MPH enhanced performance on some aspects of non-executive functioning. MPH-induced slowing of responding on a relatively complex Spatial Recognition memory task and quickened responding on a reaction time task requiring less cognitive resources suggests that MPH may act by improving self-regulatory ability. MPH may not exert its effects on neuropsychological functioning by enhancing executive processes.",
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    author = "Rhodes, {Sinead M.} and Coghill, {David R.} and Keith Matthews",
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    Acute neuropsychological effects of methylphenidate in stimulant drug-naive boys with ADHD II - broader executive and non-executive domains. / Rhodes, Sinead M.; Coghill, David R.; Matthews, Keith.

    In: Journal of Child Psychology and Psychiatry, Vol. 47, No. 11, 2006, p. 1184-1194.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Acute neuropsychological effects of methylphenidate in stimulant drug-naive boys with ADHD II - broader executive and non-executive domains

    AU - Rhodes, Sinead M.

    AU - Coghill, David R.

    AU - Matthews, Keith

    N1 - dc.publisher: Wiley-Blackwell

    PY - 2006

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    N2 - Background: Accumulating evidence supports methylphenidate-induced enhancement of neuropsychological functioning in attention deficit hyperactivity disorder (ADHD). The present study was designed to investigate the acute effects of the psychostimulant drug, methylphenidate (MPH), on neuropsychological performance in stimulant naïve boys with ADHD. Methods: Seventy-three drug-naïve boys (age 7–15) with ADHD (combined type) completed neuropsychological tasks from the CANTAB battery under randomised, placebo controlled, double-blind conditions following an acute challenge with either placebo (n = 24), .3 (n = 25) or .6 (n = 24) mg/kg oral MPH. Results: MPH did not impair performance on any task. MPH (.6 mg/kg) lengthened response latencies on a task of Spatial Recognition, shortened response times on a Reaction Time task and restored performance on a Delayed Matching to Sample visual, non-working memory task. Contrary to predictions, MPH did not enhance performance on tasks with a prominent executive component, including Go/NoGo, Spatial Working Memory, Stockings of Cambridge and Attentional Set shifting tasks. Conclusions: Acute administration of MPH to drug-naïve boys with ADHD did not impair neuropsychological performance. Acute MPH enhanced performance on some aspects of non-executive functioning. MPH-induced slowing of responding on a relatively complex Spatial Recognition memory task and quickened responding on a reaction time task requiring less cognitive resources suggests that MPH may act by improving self-regulatory ability. MPH may not exert its effects on neuropsychological functioning by enhancing executive processes.

    AB - Background: Accumulating evidence supports methylphenidate-induced enhancement of neuropsychological functioning in attention deficit hyperactivity disorder (ADHD). The present study was designed to investigate the acute effects of the psychostimulant drug, methylphenidate (MPH), on neuropsychological performance in stimulant naïve boys with ADHD. Methods: Seventy-three drug-naïve boys (age 7–15) with ADHD (combined type) completed neuropsychological tasks from the CANTAB battery under randomised, placebo controlled, double-blind conditions following an acute challenge with either placebo (n = 24), .3 (n = 25) or .6 (n = 24) mg/kg oral MPH. Results: MPH did not impair performance on any task. MPH (.6 mg/kg) lengthened response latencies on a task of Spatial Recognition, shortened response times on a Reaction Time task and restored performance on a Delayed Matching to Sample visual, non-working memory task. Contrary to predictions, MPH did not enhance performance on tasks with a prominent executive component, including Go/NoGo, Spatial Working Memory, Stockings of Cambridge and Attentional Set shifting tasks. Conclusions: Acute administration of MPH to drug-naïve boys with ADHD did not impair neuropsychological performance. Acute MPH enhanced performance on some aspects of non-executive functioning. MPH-induced slowing of responding on a relatively complex Spatial Recognition memory task and quickened responding on a reaction time task requiring less cognitive resources suggests that MPH may act by improving self-regulatory ability. MPH may not exert its effects on neuropsychological functioning by enhancing executive processes.

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    KW - Attention Deficit Disorder with Hyperactivity

    KW - Central Nervous System Stimulants

    KW - Child

    KW - Double-Blind Method

    KW - Humans

    KW - Internal-External Control

    KW - Male

    KW - Mental Recall

    KW - Methylphenidate

    KW - Neuropsychological Tests

    KW - Orientation

    KW - Pattern Recognition, Visual

    KW - Problem Solving

    KW - Reaction Time

    U2 - 10.1111/j.1469-7610.2006.01633.x

    DO - 10.1111/j.1469-7610.2006.01633.x

    M3 - Article

    VL - 47

    SP - 1184

    EP - 1194

    JO - Journal of Child Psychology and Psychiatry

    JF - Journal of Child Psychology and Psychiatry

    SN - 0021-9630

    IS - 11

    ER -