Acute pain pathways: protocol for a prospective cohort study

Molly Moore Jeffery; Mitra Ahadpour; Summer Allen; Richardae Araojo; Fernanda Bellolio; Nancy Chang; Laura Ciaccio; Lindsay Emanuel; Jonathan Fillmore; Gregg H. Gilbert; Patricia Koussis; Christine Lee; Heather Lipkind; Celeste Mallama; Tamra Meyer; Megan Moncur; Teryl Nuckols; Michael A. Pacanowski; David B. Page; Elektra Papadopoulos; Jessica D. Ritchie; Joseph S. Ross; Nilay D. Shah; Mat Soukup; Christopher O. St Clair; Stephen Tamang; Sam Torbati; Douglas W. Wallace; Yueqin Zhao; Rebekah Heckmann

doi:10.1136/bmjopen-2021-058782

Acute pain pathways: protocol for a prospective cohort study

Molly Moore Jeffery (Lead / Corresponding author), Mitra Ahadpour, Summer Allen, Richardae Araojo, Fernanda Bellolio, Nancy Chang, Laura Ciaccio, Lindsay Emanuel, Jonathan Fillmore, Gregg H. Gilbert, Patricia Koussis, Christine Lee, Heather Lipkind, Celeste Mallama, Tamra Meyer, Megan Moncur, Teryl Nuckols, Michael A. Pacanowski, David B. Page, Elektra PapadopoulosJessica D. Ritchie, Joseph S. Ross, Nilay D. Shah, Mat Soukup, Christopher O. St Clair, Stephen Tamang, Sam Torbati, Douglas W. Wallace, Yueqin Zhao, Rebekah Heckmann

Population Health and Genomics

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Abstract

Introduction: Opioid analgesics are often used to treat moderate-to-severe acute non-cancer pain; however, there is little high-quality evidence to guide clinician prescribing. An essential element to developing evidence-based guidelines is a better understanding of pain management and pain control among individuals experiencing acute pain for various common diagnoses.

Methods and analysis: This multicentre prospective observational study will recruit 1550 opioid-naïve participants with acute pain seen in diverse clinical settings including primary/urgent care, emergency departments and dental clinics. Participants will be followed for 6 months with the aid of a patient-centred health data aggregating platform that consolidates data from study questionnaires, electronic health record data on healthcare services received, prescription fill data from pharmacies, and activity and sleep data from a Fitbit activity tracker. Participants will be enrolled to represent diverse races and ethnicities and pain conditions, as well as geographical diversity. Data analysis will focus on assessing patients' patterns of pain and opioid analgesic use, along with other pain treatments; associations between patient and condition characteristics and patient-centred outcomes including resolution of pain, satisfaction with care and long-term use of opioid analgesics; and descriptive analyses of patient management of leftover opioids.

Ethics and dissemination: This study has received approval from IRBs at each site. Results will be made available to participants, funders, the research community and the public.

Trial registration number: NCT04509115.

Original language	English
Article number	e058782
Number of pages	10
Journal	BMJ Open
Volume	12
Issue number	7
DOIs	https://doi.org/10.1136/bmjopen-2021-058782
Publication status	Published - 5 Jul 2022

Keywords

Acute Pain/drug therapy
Analgesics, Opioid/therapeutic use
Emergency Service, Hospital
Humans
Multicenter Studies as Topic
Observational Studies as Topic
Opioid-Related Disorders
Pain Management/methods
Patient-Centered Care/methods
Prospective Studies
oral & maxillofacial surgery
pain management
accident & emergency medicine
primary care

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/bmjopen-2021-058782Licence: CC BY-NC

Final Published VersionFinal published version, 877 KBLicence: CC BY-NC

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Jeffery, M. M., Ahadpour, M., Allen, S., Araojo, R., Bellolio, F., Chang, N., Ciaccio, L., Emanuel, L., Fillmore, J., Gilbert, G. H., Koussis, P., Lee, C., Lipkind, H., Mallama, C., Meyer, T., Moncur, M., Nuckols, T., Pacanowski, M. A., Page, D. B., ... Heckmann, R. (2022). Acute pain pathways: protocol for a prospective cohort study. BMJ Open, 12(7), Article e058782. https://doi.org/10.1136/bmjopen-2021-058782

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title = "Acute pain pathways: protocol for a prospective cohort study",

abstract = "Introduction: Opioid analgesics are often used to treat moderate-to-severe acute non-cancer pain; however, there is little high-quality evidence to guide clinician prescribing. An essential element to developing evidence-based guidelines is a better understanding of pain management and pain control among individuals experiencing acute pain for various common diagnoses.Methods and analysis: This multicentre prospective observational study will recruit 1550 opioid-na{\"i}ve participants with acute pain seen in diverse clinical settings including primary/urgent care, emergency departments and dental clinics. Participants will be followed for 6 months with the aid of a patient-centred health data aggregating platform that consolidates data from study questionnaires, electronic health record data on healthcare services received, prescription fill data from pharmacies, and activity and sleep data from a Fitbit activity tracker. Participants will be enrolled to represent diverse races and ethnicities and pain conditions, as well as geographical diversity. Data analysis will focus on assessing patients' patterns of pain and opioid analgesic use, along with other pain treatments; associations between patient and condition characteristics and patient-centred outcomes including resolution of pain, satisfaction with care and long-term use of opioid analgesics; and descriptive analyses of patient management of leftover opioids.Ethics and dissemination: This study has received approval from IRBs at each site. Results will be made available to participants, funders, the research community and the public.Trial registration number: NCT04509115.",

keywords = "Acute Pain/drug therapy, Analgesics, Opioid/therapeutic use, Emergency Service, Hospital, Humans, Multicenter Studies as Topic, Observational Studies as Topic, Opioid-Related Disorders, Pain Management/methods, Patient-Centered Care/methods, Prospective Studies, oral & maxillofacial surgery, pain management, accident & emergency medicine, primary care",

author = "Jeffery, {Molly Moore} and Mitra Ahadpour and Summer Allen and Richardae Araojo and Fernanda Bellolio and Nancy Chang and Laura Ciaccio and Lindsay Emanuel and Jonathan Fillmore and Gilbert, {Gregg H.} and Patricia Koussis and Christine Lee and Heather Lipkind and Celeste Mallama and Tamra Meyer and Megan Moncur and Teryl Nuckols and Pacanowski, {Michael A.} and Page, {David B.} and Elektra Papadopoulos and Ritchie, {Jessica D.} and Ross, {Joseph S.} and Shah, {Nilay D.} and Mat Soukup and {St Clair}, {Christopher O.} and Stephen Tamang and Sam Torbati and Wallace, {Douglas W.} and Yueqin Zhao and Rebekah Heckmann",

note = "{\textcopyright} Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",

year = "2022",

month = jul,

day = "5",

doi = "10.1136/bmjopen-2021-058782",

language = "English",

volume = "12",

journal = "BMJ Open",

issn = "2044-6055",

publisher = "BMJ Publishing Group",

number = "7",

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Jeffery, MM, Ahadpour, M, Allen, S, Araojo, R, Bellolio, F, Chang, N, Ciaccio, L, Emanuel, L, Fillmore, J, Gilbert, GH, Koussis, P, Lee, C, Lipkind, H, Mallama, C, Meyer, T, Moncur, M, Nuckols, T, Pacanowski, MA, Page, DB, Papadopoulos, E, Ritchie, JD, Ross, JS, Shah, ND, Soukup, M, St Clair, CO, Tamang, S, Torbati, S, Wallace, DW, Zhao, Y & Heckmann, R 2022, 'Acute pain pathways: protocol for a prospective cohort study', BMJ Open, vol. 12, no. 7, e058782. https://doi.org/10.1136/bmjopen-2021-058782

TY - JOUR

T1 - Acute pain pathways

T2 - protocol for a prospective cohort study

AU - Jeffery, Molly Moore

AU - Ahadpour, Mitra

AU - Allen, Summer

AU - Araojo, Richardae

AU - Bellolio, Fernanda

AU - Chang, Nancy

AU - Ciaccio, Laura

AU - Emanuel, Lindsay

AU - Fillmore, Jonathan

AU - Gilbert, Gregg H.

AU - Koussis, Patricia

AU - Lee, Christine

AU - Lipkind, Heather

AU - Mallama, Celeste

AU - Meyer, Tamra

AU - Moncur, Megan

AU - Nuckols, Teryl

AU - Pacanowski, Michael A.

AU - Page, David B.

AU - Papadopoulos, Elektra

AU - Ritchie, Jessica D.

AU - Ross, Joseph S.

AU - Shah, Nilay D.

AU - Soukup, Mat

AU - St Clair, Christopher O.

AU - Tamang, Stephen

AU - Torbati, Sam

AU - Wallace, Douglas W.

AU - Zhao, Yueqin

AU - Heckmann, Rebekah

PY - 2022/7/5

Y1 - 2022/7/5

N2 - Introduction: Opioid analgesics are often used to treat moderate-to-severe acute non-cancer pain; however, there is little high-quality evidence to guide clinician prescribing. An essential element to developing evidence-based guidelines is a better understanding of pain management and pain control among individuals experiencing acute pain for various common diagnoses.Methods and analysis: This multicentre prospective observational study will recruit 1550 opioid-naïve participants with acute pain seen in diverse clinical settings including primary/urgent care, emergency departments and dental clinics. Participants will be followed for 6 months with the aid of a patient-centred health data aggregating platform that consolidates data from study questionnaires, electronic health record data on healthcare services received, prescription fill data from pharmacies, and activity and sleep data from a Fitbit activity tracker. Participants will be enrolled to represent diverse races and ethnicities and pain conditions, as well as geographical diversity. Data analysis will focus on assessing patients' patterns of pain and opioid analgesic use, along with other pain treatments; associations between patient and condition characteristics and patient-centred outcomes including resolution of pain, satisfaction with care and long-term use of opioid analgesics; and descriptive analyses of patient management of leftover opioids.Ethics and dissemination: This study has received approval from IRBs at each site. Results will be made available to participants, funders, the research community and the public.Trial registration number: NCT04509115.

AB - Introduction: Opioid analgesics are often used to treat moderate-to-severe acute non-cancer pain; however, there is little high-quality evidence to guide clinician prescribing. An essential element to developing evidence-based guidelines is a better understanding of pain management and pain control among individuals experiencing acute pain for various common diagnoses.Methods and analysis: This multicentre prospective observational study will recruit 1550 opioid-naïve participants with acute pain seen in diverse clinical settings including primary/urgent care, emergency departments and dental clinics. Participants will be followed for 6 months with the aid of a patient-centred health data aggregating platform that consolidates data from study questionnaires, electronic health record data on healthcare services received, prescription fill data from pharmacies, and activity and sleep data from a Fitbit activity tracker. Participants will be enrolled to represent diverse races and ethnicities and pain conditions, as well as geographical diversity. Data analysis will focus on assessing patients' patterns of pain and opioid analgesic use, along with other pain treatments; associations between patient and condition characteristics and patient-centred outcomes including resolution of pain, satisfaction with care and long-term use of opioid analgesics; and descriptive analyses of patient management of leftover opioids.Ethics and dissemination: This study has received approval from IRBs at each site. Results will be made available to participants, funders, the research community and the public.Trial registration number: NCT04509115.

KW - Acute Pain/drug therapy

KW - Analgesics, Opioid/therapeutic use

KW - Emergency Service, Hospital

KW - Humans

KW - Multicenter Studies as Topic

KW - Observational Studies as Topic

KW - Opioid-Related Disorders

KW - Pain Management/methods

KW - Patient-Centered Care/methods

KW - Prospective Studies

KW - oral & maxillofacial surgery

KW - pain management

KW - accident & emergency medicine

KW - primary care

UR - http://www.scopus.com/inward/record.url?scp=85133250003&partnerID=8YFLogxK

U2 - 10.1136/bmjopen-2021-058782

DO - 10.1136/bmjopen-2021-058782

M3 - Article

C2 - 35790333

SN - 2044-6055

VL - 12

JO - BMJ Open

JF - BMJ Open

IS - 7

M1 - e058782

ER -

Acute pain pathways: protocol for a prospective cohort study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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