Adaption to chemical agents in the environment is a fundamental part of the evolutionary process and a large number of genes have evolved to specifically detoxify potentially harmful chemical agents. These genes can act at various levels within cells and determine circulating chemical or toxin concentrations, and uptake and efflux rates as well as intracellular detoxification enzymes, such as the cytochrome P-450-dependent mono-oxygenases and glutathione S-transferases. These multigene families of proteins play a central role in chemical and drug detoxification and their polymorphic expression may well be a factor in disease susceptibility.
|Title of host publication||Cellular responses to stress|
|Editors||C. P. Downes, C. R. Wolf, D. P. Lane|
|Place of Publication||London|
|Number of pages||11|
|Publication status||Published - 1999|
|Name||Biochemical Society symposia|