Adaptive responses to environmental chemicals

C. R. Wolf, G. Smith, A. G. Smith, K. Brown, C. J. Henderson

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    1 Citation (Scopus)

    Abstract

    Adaption to chemical agents in the environment is a fundamental part of the evolutionary process and a large number of genes have evolved to specifically detoxify potentially harmful chemical agents. These genes can act at various levels within cells and determine circulating chemical or toxin concentrations, and uptake and efflux rates as well as intracellular detoxification enzymes, such as the cytochrome P-450-dependent mono-oxygenases and glutathione S-transferases. These multigene families of proteins play a central role in chemical and drug detoxification and their polymorphic expression may well be a factor in disease susceptibility.
    Original languageEnglish
    Title of host publicationCellular responses to stress
    EditorsC. P. Downes, C. R. Wolf, D. P. Lane
    Place of PublicationLondon
    PublisherPortland Press Ltd.
    Pages129-139
    Number of pages11
    ISBN (Print)1855781239
    Publication statusPublished - 1999

    Publication series

    NameBiochemical Society symposia
    PublisherPortland Press
    Number64
    ISSN (Print)0067-8964

    Fingerprint

    Oxygenases
    Disease Susceptibility
    Multigene Family
    Glutathione Transferase
    Cytochrome P-450 Enzyme System
    Genes
    Enzymes
    Pharmaceutical Preparations
    Proteins

    Cite this

    Wolf, C. R., Smith, G., Smith, A. G., Brown, K., & Henderson, C. J. (1999). Adaptive responses to environmental chemicals. In C. P. Downes, C. R. Wolf, & D. P. Lane (Eds.), Cellular responses to stress (pp. 129-139). (Biochemical Society symposia; No. 64). London: Portland Press Ltd..
    Wolf, C. R. ; Smith, G. ; Smith, A. G. ; Brown, K. ; Henderson, C. J. / Adaptive responses to environmental chemicals. Cellular responses to stress. editor / C. P. Downes ; C. R. Wolf ; D. P. Lane. London : Portland Press Ltd., 1999. pp. 129-139 (Biochemical Society symposia; 64).
    @inproceedings{6219d3d624a24399940890652425b074,
    title = "Adaptive responses to environmental chemicals",
    abstract = "Adaption to chemical agents in the environment is a fundamental part of the evolutionary process and a large number of genes have evolved to specifically detoxify potentially harmful chemical agents. These genes can act at various levels within cells and determine circulating chemical or toxin concentrations, and uptake and efflux rates as well as intracellular detoxification enzymes, such as the cytochrome P-450-dependent mono-oxygenases and glutathione S-transferases. These multigene families of proteins play a central role in chemical and drug detoxification and their polymorphic expression may well be a factor in disease susceptibility.",
    author = "Wolf, {C. R.} and G. Smith and Smith, {A. G.} and K. Brown and Henderson, {C. J.}",
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    series = "Biochemical Society symposia",
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    pages = "129--139",
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    Wolf, CR, Smith, G, Smith, AG, Brown, K & Henderson, CJ 1999, Adaptive responses to environmental chemicals. in CP Downes, CR Wolf & DP Lane (eds), Cellular responses to stress. Biochemical Society symposia, no. 64, Portland Press Ltd., London, pp. 129-139.

    Adaptive responses to environmental chemicals. / Wolf, C. R.; Smith, G.; Smith, A. G.; Brown, K.; Henderson, C. J.

    Cellular responses to stress. ed. / C. P. Downes; C. R. Wolf; D. P. Lane. London : Portland Press Ltd., 1999. p. 129-139 (Biochemical Society symposia; No. 64).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    TY - GEN

    T1 - Adaptive responses to environmental chemicals

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    AU - Smith, G.

    AU - Smith, A. G.

    AU - Brown, K.

    AU - Henderson, C. J.

    PY - 1999

    Y1 - 1999

    N2 - Adaption to chemical agents in the environment is a fundamental part of the evolutionary process and a large number of genes have evolved to specifically detoxify potentially harmful chemical agents. These genes can act at various levels within cells and determine circulating chemical or toxin concentrations, and uptake and efflux rates as well as intracellular detoxification enzymes, such as the cytochrome P-450-dependent mono-oxygenases and glutathione S-transferases. These multigene families of proteins play a central role in chemical and drug detoxification and their polymorphic expression may well be a factor in disease susceptibility.

    AB - Adaption to chemical agents in the environment is a fundamental part of the evolutionary process and a large number of genes have evolved to specifically detoxify potentially harmful chemical agents. These genes can act at various levels within cells and determine circulating chemical or toxin concentrations, and uptake and efflux rates as well as intracellular detoxification enzymes, such as the cytochrome P-450-dependent mono-oxygenases and glutathione S-transferases. These multigene families of proteins play a central role in chemical and drug detoxification and their polymorphic expression may well be a factor in disease susceptibility.

    M3 - Conference contribution

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    SN - 1855781239

    T3 - Biochemical Society symposia

    SP - 129

    EP - 139

    BT - Cellular responses to stress

    A2 - Downes, C. P.

    A2 - Wolf, C. R.

    A2 - Lane, D. P.

    PB - Portland Press Ltd.

    CY - London

    ER -

    Wolf CR, Smith G, Smith AG, Brown K, Henderson CJ. Adaptive responses to environmental chemicals. In Downes CP, Wolf CR, Lane DP, editors, Cellular responses to stress. London: Portland Press Ltd. 1999. p. 129-139. (Biochemical Society symposia; 64).