Adaptive responses to environmental chemicals

C. R. Wolf, G. Smith, A. G. Smith, K. Brown, C. J. Henderson

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    1 Citation (Scopus)

    Abstract

    Adaption to chemical agents in the environment is a fundamental part of the evolutionary process and a large number of genes have evolved to specifically detoxify potentially harmful chemical agents. These genes can act at various levels within cells and determine circulating chemical or toxin concentrations, and uptake and efflux rates as well as intracellular detoxification enzymes, such as the cytochrome P-450-dependent mono-oxygenases and glutathione S-transferases. These multigene families of proteins play a central role in chemical and drug detoxification and their polymorphic expression may well be a factor in disease susceptibility.
    Original languageEnglish
    Title of host publicationCellular responses to stress
    EditorsC. P. Downes, C. R. Wolf, D. P. Lane
    Place of PublicationLondon
    PublisherPortland Press
    Pages129-139
    Number of pages11
    ISBN (Print)1855781239
    Publication statusPublished - 1999

    Publication series

    NameBiochemical Society symposia
    PublisherPortland Press
    Number64
    ISSN (Print)0067-8964

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