Adenosine-5'-triphosphate-sensitive ion channels in neonatal rat cultured central neurones

M. L. J. Ashford, N. C. Sturgess, N. J. Trout, N. J. Gardner, C. N. Hales

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    225 Citations (Scopus)


    ATP-sensitive channels were observed in isolated inside-out membrane patches from rat cultured central neurones. Two types of ATP-sensitive K+ channels were present in cortical neurones, one which had its open-state probability increased, the other its open-state probability decreased by application of ATP to the cytoplasmic membrane surface. Another, ATP-sensitive channel differing in ion conductance from all previously reported ATP-sensitive channels was also seen in patches from cortical neurones. This channel was nonselective with respect to Na+, K+ and Cl- ions and ATP produced a "flickery" type of block. The non-hydrolysable analogue, AMPPNP, did not mimic ATP and prevented ATP action. Preliminary experiments indicate that similar, but not, identical ATP-sensitive channels exist in cerebellar neurones.

    Original languageEnglish
    Pages (from-to)297-304
    Number of pages8
    JournalPflugers Archiv-European Journal of Physiology
    Issue number3
    Publication statusPublished - Aug 1988


    • Rats
    • Cerebral Cortex
    • Animals, Newborn
    • Animals
    • Cells, Cultured
    • Neurons
    • Ion Channels
    • Cerebellum
    • Cell Membrane
    • Adenosine Triphosphate
    • Potassium Channels


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