Adhesion molecule in untreated inflammatory arthritis

D. M. Mulherin; D. J. Veale; J. J. F. Belch; B. Bresnihan; O. Fitzgerald

doi:10.1093/qjmed/89.3.195

Adhesion molecule in untreated inflammatory arthritis

D. M. Mulherin, D. J. Veale, J. J. F. Belch, B. Bresnihan, O. Fitzgerald

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Adhesion molecules play a critical role in regulating leucocyte migration at sites of inflammation. The relationship of soluble forms in serum or synovial fluid (SF) to synovial membrane expression in inflammatory arthritis is controversial. We examined soluble intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin levels in matched serum and SF, and their relationship to expression in synovium obtained at the same time in 13 patients with previously untreated inflammatory arthritis, Serum-soluble (s)ICAM-1 correlated with sedimentation rate (T=0.45), Ritchie articular index (T=0.47) and SF sICAM-1 (T=0.48), and SF sICAM-1 correlated with membrane ICAM-1 expression (p

Original language	English
Pages (from-to)	195-203
Number of pages	9
Journal	Quarterly Journal of Medicine
Volume	89
Issue number	3
DOIs	https://doi.org/10.1093/qjmed/89.3.195
Publication status	Published - 1996

Keywords

SYNOVIAL-MEMBRANE
ENDOTHELIAL-CELLS
ANTIGEN
CYTOKINES
TUMOR-NECROSIS-FACTOR
ICAM-1
EXPRESSION
SYSTEMIC LUPUS-ERYTHEMATOSUS
ELAM-1
RHEUMATOID-ARTHRITIS

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title = "Adhesion molecule in untreated inflammatory arthritis",

abstract = "Adhesion molecules play a critical role in regulating leucocyte migration at sites of inflammation. The relationship of soluble forms in serum or synovial fluid (SF) to synovial membrane expression in inflammatory arthritis is controversial. We examined soluble intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin levels in matched serum and SF, and their relationship to expression in synovium obtained at the same time in 13 patients with previously untreated inflammatory arthritis, Serum-soluble (s)ICAM-1 correlated with sedimentation rate (T=0.45), Ritchie articular index (T=0.47) and SF sICAM-1 (T=0.48), and SF sICAM-1 correlated with membrane ICAM-1 expression (p",

keywords = "SYNOVIAL-MEMBRANE, ENDOTHELIAL-CELLS, ANTIGEN, CYTOKINES, TUMOR-NECROSIS-FACTOR, ICAM-1, EXPRESSION, SYSTEMIC LUPUS-ERYTHEMATOSUS, ELAM-1, RHEUMATOID-ARTHRITIS",

author = "Mulherin, {D. M.} and Veale, {D. J.} and Belch, {J. J. F.} and B. Bresnihan and O. Fitzgerald",

year = "1996",

doi = "10.1093/qjmed/89.3.195",

language = "English",

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pages = "195--203",

journal = "Quarterly Journal of Medicine",

issn = "0033-5622",

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T1 - Adhesion molecule in untreated inflammatory arthritis

AU - Mulherin, D. M.

AU - Veale, D. J.

AU - Belch, J. J. F.

AU - Bresnihan, B.

AU - Fitzgerald, O.

PY - 1996

Y1 - 1996

N2 - Adhesion molecules play a critical role in regulating leucocyte migration at sites of inflammation. The relationship of soluble forms in serum or synovial fluid (SF) to synovial membrane expression in inflammatory arthritis is controversial. We examined soluble intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin levels in matched serum and SF, and their relationship to expression in synovium obtained at the same time in 13 patients with previously untreated inflammatory arthritis, Serum-soluble (s)ICAM-1 correlated with sedimentation rate (T=0.45), Ritchie articular index (T=0.47) and SF sICAM-1 (T=0.48), and SF sICAM-1 correlated with membrane ICAM-1 expression (p

AB - Adhesion molecules play a critical role in regulating leucocyte migration at sites of inflammation. The relationship of soluble forms in serum or synovial fluid (SF) to synovial membrane expression in inflammatory arthritis is controversial. We examined soluble intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin levels in matched serum and SF, and their relationship to expression in synovium obtained at the same time in 13 patients with previously untreated inflammatory arthritis, Serum-soluble (s)ICAM-1 correlated with sedimentation rate (T=0.45), Ritchie articular index (T=0.47) and SF sICAM-1 (T=0.48), and SF sICAM-1 correlated with membrane ICAM-1 expression (p

KW - SYNOVIAL-MEMBRANE

KW - ENDOTHELIAL-CELLS

KW - ANTIGEN

KW - CYTOKINES

KW - TUMOR-NECROSIS-FACTOR

KW - ICAM-1

KW - EXPRESSION

KW - SYSTEMIC LUPUS-ERYTHEMATOSUS

KW - ELAM-1

KW - RHEUMATOID-ARTHRITIS

U2 - 10.1093/qjmed/89.3.195

DO - 10.1093/qjmed/89.3.195

M3 - Article

SN - 0033-5622

VL - 89

SP - 195

EP - 203

JO - Quarterly Journal of Medicine

JF - Quarterly Journal of Medicine

IS - 3

ER -

Adhesion molecule in untreated inflammatory arthritis

Abstract

Keywords

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