Adhesion molecule in untreated inflammatory arthritis

D. M. Mulherin, D. J. Veale, J. J. F. Belch, B. Bresnihan, O. Fitzgerald

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    Adhesion molecules play a critical role in regulating leucocyte migration at sites of inflammation. The relationship of soluble forms in serum or synovial fluid (SF) to synovial membrane expression in inflammatory arthritis is controversial. We examined soluble intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin levels in matched serum and SF, and their relationship to expression in synovium obtained at the same time in 13 patients with previously untreated inflammatory arthritis, Serum-soluble (s)ICAM-1 correlated with sedimentation rate (T=0.45), Ritchie articular index (T=0.47) and SF sICAM-1 (T=0.48), and SF sICAM-1 correlated with membrane ICAM-1 expression (p

    Original languageEnglish
    Pages (from-to)195-203
    Number of pages9
    JournalQuarterly Journal of Medicine
    Volume89
    Issue number3
    DOIs
    Publication statusPublished - 1996

    Keywords

    • SYNOVIAL-MEMBRANE
    • ENDOTHELIAL-CELLS
    • ANTIGEN
    • CYTOKINES
    • TUMOR-NECROSIS-FACTOR
    • ICAM-1
    • EXPRESSION
    • SYSTEMIC LUPUS-ERYTHEMATOSUS
    • ELAM-1
    • RHEUMATOID-ARTHRITIS

    Cite this

    Mulherin, D. M. ; Veale, D. J. ; Belch, J. J. F. ; Bresnihan, B. ; Fitzgerald, O. / Adhesion molecule in untreated inflammatory arthritis. In: Quarterly Journal of Medicine. 1996 ; Vol. 89, No. 3. pp. 195-203.
    @article{71d3ca7ee47d4f57bbc0a22a6d7e4700,
    title = "Adhesion molecule in untreated inflammatory arthritis",
    abstract = "Adhesion molecules play a critical role in regulating leucocyte migration at sites of inflammation. The relationship of soluble forms in serum or synovial fluid (SF) to synovial membrane expression in inflammatory arthritis is controversial. We examined soluble intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin levels in matched serum and SF, and their relationship to expression in synovium obtained at the same time in 13 patients with previously untreated inflammatory arthritis, Serum-soluble (s)ICAM-1 correlated with sedimentation rate (T=0.45), Ritchie articular index (T=0.47) and SF sICAM-1 (T=0.48), and SF sICAM-1 correlated with membrane ICAM-1 expression (p",
    keywords = "SYNOVIAL-MEMBRANE, ENDOTHELIAL-CELLS, ANTIGEN, CYTOKINES, TUMOR-NECROSIS-FACTOR, ICAM-1, EXPRESSION, SYSTEMIC LUPUS-ERYTHEMATOSUS, ELAM-1, RHEUMATOID-ARTHRITIS",
    author = "Mulherin, {D. M.} and Veale, {D. J.} and Belch, {J. J. F.} and B. Bresnihan and O. Fitzgerald",
    year = "1996",
    doi = "10.1093/qjmed/89.3.195",
    language = "English",
    volume = "89",
    pages = "195--203",
    journal = "Quarterly Journal of Medicine",
    issn = "0033-5622",
    publisher = "Oxford University Press",
    number = "3",

    }

    Mulherin, DM, Veale, DJ, Belch, JJF, Bresnihan, B & Fitzgerald, O 1996, 'Adhesion molecule in untreated inflammatory arthritis', Quarterly Journal of Medicine, vol. 89, no. 3, pp. 195-203. https://doi.org/10.1093/qjmed/89.3.195

    Adhesion molecule in untreated inflammatory arthritis. / Mulherin, D. M.; Veale, D. J.; Belch, J. J. F.; Bresnihan, B.; Fitzgerald, O.

    In: Quarterly Journal of Medicine, Vol. 89, No. 3, 1996, p. 195-203.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Adhesion molecule in untreated inflammatory arthritis

    AU - Mulherin, D. M.

    AU - Veale, D. J.

    AU - Belch, J. J. F.

    AU - Bresnihan, B.

    AU - Fitzgerald, O.

    PY - 1996

    Y1 - 1996

    N2 - Adhesion molecules play a critical role in regulating leucocyte migration at sites of inflammation. The relationship of soluble forms in serum or synovial fluid (SF) to synovial membrane expression in inflammatory arthritis is controversial. We examined soluble intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin levels in matched serum and SF, and their relationship to expression in synovium obtained at the same time in 13 patients with previously untreated inflammatory arthritis, Serum-soluble (s)ICAM-1 correlated with sedimentation rate (T=0.45), Ritchie articular index (T=0.47) and SF sICAM-1 (T=0.48), and SF sICAM-1 correlated with membrane ICAM-1 expression (p

    AB - Adhesion molecules play a critical role in regulating leucocyte migration at sites of inflammation. The relationship of soluble forms in serum or synovial fluid (SF) to synovial membrane expression in inflammatory arthritis is controversial. We examined soluble intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin levels in matched serum and SF, and their relationship to expression in synovium obtained at the same time in 13 patients with previously untreated inflammatory arthritis, Serum-soluble (s)ICAM-1 correlated with sedimentation rate (T=0.45), Ritchie articular index (T=0.47) and SF sICAM-1 (T=0.48), and SF sICAM-1 correlated with membrane ICAM-1 expression (p

    KW - SYNOVIAL-MEMBRANE

    KW - ENDOTHELIAL-CELLS

    KW - ANTIGEN

    KW - CYTOKINES

    KW - TUMOR-NECROSIS-FACTOR

    KW - ICAM-1

    KW - EXPRESSION

    KW - SYSTEMIC LUPUS-ERYTHEMATOSUS

    KW - ELAM-1

    KW - RHEUMATOID-ARTHRITIS

    U2 - 10.1093/qjmed/89.3.195

    DO - 10.1093/qjmed/89.3.195

    M3 - Article

    VL - 89

    SP - 195

    EP - 203

    JO - Quarterly Journal of Medicine

    JF - Quarterly Journal of Medicine

    SN - 0033-5622

    IS - 3

    ER -