Admixture analysis of age at onset in bipolar disorder

Federica Tozzi, Mirko Manchia, Nicholas W. Galwey, Giovanni Severino, Maria Del Zompo, Richard Day, Keith Matthews, John Strauss, James L. Kennedy, Peter McGuffin, John B. Vincent, Anne Farmer, Pierandrea Muglia

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    37 Citations (Scopus)

    Abstract

    The aim of this study was to identify whether age at onset (MO) identifies Bipolar Disorder (BD) subtypes. and to test whether the subgroups were confirmed by different clinical profiles. Admixture analysis was applied to determine a model that best fit the observed distribution of MO in 964 BD patients. Three distributions of MO were identified, and age means were 16.1 (S.D. 4.2), 25.4 (S.D. 2.5) and 32.2 (S.D. 9.5) years. A significant increased rate of suicide attempts, Bipolar I (BD I) caseness, and depressive onset was observed in the early-onset group when compared to those with later-onset by means of chi(2). Findings from extant studies and our results are remarkably consistent in showing that BD can be subdivided into three groups based on MO distributions, and that early-onset is associated with higher rates of suicide attempts. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)27-32
    Number of pages6
    JournalPsychiatry Research
    Volume185
    Issue number1-2
    DOIs
    Publication statusPublished - 30 Jan 2011

    Keywords

    • Affective disorders
    • Age at onset
    • Admixture analysis
    • Suicide
    • NATIONAL-COMORBIDITY-SURVEY
    • MANIC-DEPRESSIVE ILLNESS
    • I AFFECTIVE-DISORDER
    • CLINICAL CHARACTERISTICS
    • 12-MONTH PREVALENCE
    • 3 SUBGROUPS
    • EPIDEMIOLOGY
    • GENETICS
    • LIFETIME
    • POLARITY

    Cite this

    Tozzi, F., Manchia, M., Galwey, N. W., Severino, G., Del Zompo, M., Day, R., Matthews, K., Strauss, J., Kennedy, J. L., McGuffin, P., Vincent, J. B., Farmer, A., & Muglia, P. (2011). Admixture analysis of age at onset in bipolar disorder. Psychiatry Research, 185(1-2), 27-32. https://doi.org/10.1016/j.psychres.2009.11.025