Admixture analysis of age at onset in bipolar disorder

Federica Tozzi; Mirko Manchia; Nicholas W. Galwey; Giovanni Severino; Maria Del Zompo; Richard Day; Keith Matthews; John Strauss; James L. Kennedy; Peter McGuffin; John B. Vincent; Anne Farmer; Pierandrea Muglia

doi:10.1016/j.psychres.2009.11.025

Admixture analysis of age at onset in bipolar disorder

Federica Tozzi
, Mirko Manchia
, Nicholas W. Galwey
, Giovanni Severino
, Maria Del Zompo
, Richard Day
, Keith Matthews
, John Strauss
, James L. Kennedy
, Peter McGuffin
, John B. Vincent
, Anne Farmer
, Pierandrea Muglia

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

The aim of this study was to identify whether age at onset (MO) identifies Bipolar Disorder (BD) subtypes. and to test whether the subgroups were confirmed by different clinical profiles. Admixture analysis was applied to determine a model that best fit the observed distribution of MO in 964 BD patients. Three distributions of MO were identified, and age means were 16.1 (S.D. 4.2), 25.4 (S.D. 2.5) and 32.2 (S.D. 9.5) years. A significant increased rate of suicide attempts, Bipolar I (BD I) caseness, and depressive onset was observed in the early-onset group when compared to those with later-onset by means of chi(2). Findings from extant studies and our results are remarkably consistent in showing that BD can be subdivided into three groups based on MO distributions, and that early-onset is associated with higher rates of suicide attempts. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	27-32
Number of pages	6
Journal	Psychiatry Research
Volume	185
Issue number	1-2
DOIs	https://doi.org/10.1016/j.psychres.2009.11.025
Publication status	Published - 30 Jan 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Affective disorders
Age at onset
Admixture analysis
Suicide
NATIONAL-COMORBIDITY-SURVEY
MANIC-DEPRESSIVE ILLNESS
I AFFECTIVE-DISORDER
CLINICAL CHARACTERISTICS
12-MONTH PREVALENCE
3 SUBGROUPS
EPIDEMIOLOGY
GENETICS
LIFETIME
POLARITY

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10.1016/j.psychres.2009.11.025

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title = "Admixture analysis of age at onset in bipolar disorder",

abstract = "The aim of this study was to identify whether age at onset (MO) identifies Bipolar Disorder (BD) subtypes. and to test whether the subgroups were confirmed by different clinical profiles. Admixture analysis was applied to determine a model that best fit the observed distribution of MO in 964 BD patients. Three distributions of MO were identified, and age means were 16.1 (S.D. 4.2), 25.4 (S.D. 2.5) and 32.2 (S.D. 9.5) years. A significant increased rate of suicide attempts, Bipolar I (BD I) caseness, and depressive onset was observed in the early-onset group when compared to those with later-onset by means of chi(2). Findings from extant studies and our results are remarkably consistent in showing that BD can be subdivided into three groups based on MO distributions, and that early-onset is associated with higher rates of suicide attempts. (C) 2009 Elsevier Ireland Ltd. All rights reserved.",

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author = "Federica Tozzi and Mirko Manchia and Galwey, \{Nicholas W.\} and Giovanni Severino and \{Del Zompo\}, Maria and Richard Day and Keith Matthews and John Strauss and Kennedy, \{James L.\} and Peter McGuffin and Vincent, \{John B.\} and Anne Farmer and Pierandrea Muglia",

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doi = "10.1016/j.psychres.2009.11.025",

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T1 - Admixture analysis of age at onset in bipolar disorder

AU - Tozzi, Federica

AU - Manchia, Mirko

AU - Galwey, Nicholas W.

AU - Severino, Giovanni

AU - Del Zompo, Maria

AU - Day, Richard

AU - Matthews, Keith

AU - Strauss, John

AU - Kennedy, James L.

AU - McGuffin, Peter

AU - Vincent, John B.

AU - Farmer, Anne

AU - Muglia, Pierandrea

PY - 2011/1/30

Y1 - 2011/1/30

N2 - The aim of this study was to identify whether age at onset (MO) identifies Bipolar Disorder (BD) subtypes. and to test whether the subgroups were confirmed by different clinical profiles. Admixture analysis was applied to determine a model that best fit the observed distribution of MO in 964 BD patients. Three distributions of MO were identified, and age means were 16.1 (S.D. 4.2), 25.4 (S.D. 2.5) and 32.2 (S.D. 9.5) years. A significant increased rate of suicide attempts, Bipolar I (BD I) caseness, and depressive onset was observed in the early-onset group when compared to those with later-onset by means of chi(2). Findings from extant studies and our results are remarkably consistent in showing that BD can be subdivided into three groups based on MO distributions, and that early-onset is associated with higher rates of suicide attempts. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

AB - The aim of this study was to identify whether age at onset (MO) identifies Bipolar Disorder (BD) subtypes. and to test whether the subgroups were confirmed by different clinical profiles. Admixture analysis was applied to determine a model that best fit the observed distribution of MO in 964 BD patients. Three distributions of MO were identified, and age means were 16.1 (S.D. 4.2), 25.4 (S.D. 2.5) and 32.2 (S.D. 9.5) years. A significant increased rate of suicide attempts, Bipolar I (BD I) caseness, and depressive onset was observed in the early-onset group when compared to those with later-onset by means of chi(2). Findings from extant studies and our results are remarkably consistent in showing that BD can be subdivided into three groups based on MO distributions, and that early-onset is associated with higher rates of suicide attempts. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

KW - Affective disorders

KW - Age at onset

KW - Admixture analysis

KW - Suicide

KW - NATIONAL-COMORBIDITY-SURVEY

KW - MANIC-DEPRESSIVE ILLNESS

KW - I AFFECTIVE-DISORDER

KW - CLINICAL CHARACTERISTICS

KW - 12-MONTH PREVALENCE

KW - 3 SUBGROUPS

KW - EPIDEMIOLOGY

KW - GENETICS

KW - LIFETIME

KW - POLARITY

U2 - 10.1016/j.psychres.2009.11.025

DO - 10.1016/j.psychres.2009.11.025

M3 - Article

C2 - 20580841

SN - 0165-1781

VL - 185

SP - 27

EP - 32

JO - Psychiatry Research

JF - Psychiatry Research

IS - 1-2

ER -

Admixture analysis of age at onset in bipolar disorder

Abstract

UN SDGs

Keywords

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