Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis

David Wormser, Emanuele Di Angelantonio, Stephen Kaptoge, Angela M. Wood, Pei Gao, Qi Sun, Goeran Walldius, Randi Selmer, W. M. Monique Verschuren, H. Bas Bueno-de-Mesquita, Gunnar Engstrom, Paul M. Ridker, Inger Njolstad, Hiroyasu Iso, Ingar Holme, Simona Giampaoli, Hugh Tunstall-Pedoe, J. Michael Gaziano, Eric Brunner, Frank KeeAlberto Tosetto, Christa Meisinger, Hermann Brenner, Pierre Ducimetiere, Peter H. Whincup, Robert W. Tipping, Ian Ford, Peter Cremer, Albert Hofman, Lars Wilhelmsen, Robert Clarke, Ian H. de Boer, J. Wouter Jukema, Alejandro Marin Ibanez, Debbie A. Lawlor, Ralph B. D'Agostino, Beatriz Rodriguez, Edoardo Casiglia, Coen D. A. Stehouwer, Leon A. Simons, Paul J. Nietert, Elizabeth Barrett-Connor, Demosthenes B. Panagiotakos, Cecilia Bjorkelund, Timo E. Strandberg, Sylvia Wassertheil-Smoller, Dan G. Blazer, Tom W. Meade, Lennart Welin, Mark Woodward, Emerging Risk Factors Collaboratio

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    Abstract

    Background The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain.

    Methods We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies.

    Results For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators.

    Conclusion Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases.

    Original languageEnglish
    Pages (from-to)1419-1433
    Number of pages15
    JournalInternational Journal of Epidemiology
    Volume41
    Issue number5
    DOIs
    Publication statusPublished - 2012

    Cite this

    Wormser, D., Di Angelantonio, E., Kaptoge, S., Wood, A. M., Gao, P., Sun, Q., Walldius, G., Selmer, R., Verschuren, W. M. M., Bueno-de-Mesquita, H. B., Engstrom, G., Ridker, P. M., Njolstad, I., Iso, H., Holme, I., Giampaoli, S., Tunstall-Pedoe, H., Gaziano, J. M., Brunner, E., ... Emerging Risk Factors Collaboratio (2012). Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis. International Journal of Epidemiology, 41(5), 1419-1433. https://doi.org/10.1093/ije/dys086