Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis

David Wormser, Emanuele Di Angelantonio, Stephen Kaptoge, Angela M. Wood, Pei Gao, Qi Sun, Goeran Walldius, Randi Selmer, W. M. Monique Verschuren, H. Bas Bueno-de-Mesquita, Gunnar Engstrom, Paul M. Ridker, Inger Njolstad, Hiroyasu Iso, Ingar Holme, Simona Giampaoli, Hugh Tunstall-Pedoe, J. Michael Gaziano, Eric Brunner, Frank KeeAlberto Tosetto, Christa Meisinger, Hermann Brenner, Pierre Ducimetiere, Peter H. Whincup, Robert W. Tipping, Ian Ford, Peter Cremer, Albert Hofman, Lars Wilhelmsen, Robert Clarke, Ian H. de Boer, J. Wouter Jukema, Alejandro Marin Ibanez, Debbie A. Lawlor, Ralph B. D'Agostino, Beatriz Rodriguez, Edoardo Casiglia, Coen D. A. Stehouwer, Leon A. Simons, Paul J. Nietert, Elizabeth Barrett-Connor, Demosthenes B. Panagiotakos, Cecilia Bjorkelund, Timo E. Strandberg, Sylvia Wassertheil-Smoller, Dan G. Blazer, Tom W. Meade, Lennart Welin, Mark Woodward, Emerging Risk Factors Collaboratio

    Research output: Contribution to journalArticle

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    Abstract

    Background The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain.

    Methods We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies.

    Results For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators.

    Conclusion Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases.

    Original languageEnglish
    Pages (from-to)1419-1433
    Number of pages15
    JournalInternational Journal of Epidemiology
    Volume41
    Issue number5
    DOIs
    Publication statusPublished - 2012

    Cite this

    Wormser, D., Di Angelantonio, E., Kaptoge, S., Wood, A. M., Gao, P., Sun, Q., ... Emerging Risk Factors Collaboratio (2012). Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis. International Journal of Epidemiology, 41(5), 1419-1433. https://doi.org/10.1093/ije/dys086
    Wormser, David ; Di Angelantonio, Emanuele ; Kaptoge, Stephen ; Wood, Angela M. ; Gao, Pei ; Sun, Qi ; Walldius, Goeran ; Selmer, Randi ; Verschuren, W. M. Monique ; Bueno-de-Mesquita, H. Bas ; Engstrom, Gunnar ; Ridker, Paul M. ; Njolstad, Inger ; Iso, Hiroyasu ; Holme, Ingar ; Giampaoli, Simona ; Tunstall-Pedoe, Hugh ; Gaziano, J. Michael ; Brunner, Eric ; Kee, Frank ; Tosetto, Alberto ; Meisinger, Christa ; Brenner, Hermann ; Ducimetiere, Pierre ; Whincup, Peter H. ; Tipping, Robert W. ; Ford, Ian ; Cremer, Peter ; Hofman, Albert ; Wilhelmsen, Lars ; Clarke, Robert ; de Boer, Ian H. ; Jukema, J. Wouter ; Ibanez, Alejandro Marin ; Lawlor, Debbie A. ; D'Agostino, Ralph B. ; Rodriguez, Beatriz ; Casiglia, Edoardo ; Stehouwer, Coen D. A. ; Simons, Leon A. ; Nietert, Paul J. ; Barrett-Connor, Elizabeth ; Panagiotakos, Demosthenes B. ; Bjorkelund, Cecilia ; Strandberg, Timo E. ; Wassertheil-Smoller, Sylvia ; Blazer, Dan G. ; Meade, Tom W. ; Welin, Lennart ; Woodward, Mark ; Emerging Risk Factors Collaboratio. / Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis. In: International Journal of Epidemiology. 2012 ; Vol. 41, No. 5. pp. 1419-1433.
    @article{84c4b07d4f194578968c402d241d7631,
    title = "Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis",
    abstract = "Background The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain.Methods We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies.Results For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95{\%} confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators.Conclusion Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases.",
    author = "David Wormser and {Di Angelantonio}, Emanuele and Stephen Kaptoge and Wood, {Angela M.} and Pei Gao and Qi Sun and Goeran Walldius and Randi Selmer and Verschuren, {W. M. Monique} and Bueno-de-Mesquita, {H. Bas} and Gunnar Engstrom and Ridker, {Paul M.} and Inger Njolstad and Hiroyasu Iso and Ingar Holme and Simona Giampaoli and Hugh Tunstall-Pedoe and Gaziano, {J. Michael} and Eric Brunner and Frank Kee and Alberto Tosetto and Christa Meisinger and Hermann Brenner and Pierre Ducimetiere and Whincup, {Peter H.} and Tipping, {Robert W.} and Ian Ford and Peter Cremer and Albert Hofman and Lars Wilhelmsen and Robert Clarke and {de Boer}, {Ian H.} and Jukema, {J. Wouter} and Ibanez, {Alejandro Marin} and Lawlor, {Debbie A.} and D'Agostino, {Ralph B.} and Beatriz Rodriguez and Edoardo Casiglia and Stehouwer, {Coen D. A.} and Simons, {Leon A.} and Nietert, {Paul J.} and Elizabeth Barrett-Connor and Panagiotakos, {Demosthenes B.} and Cecilia Bjorkelund and Strandberg, {Timo E.} and Sylvia Wassertheil-Smoller and Blazer, {Dan G.} and Meade, {Tom W.} and Lennart Welin and Mark Woodward and {Emerging Risk Factors Collaboratio}",
    year = "2012",
    doi = "10.1093/ije/dys086",
    language = "English",
    volume = "41",
    pages = "1419--1433",
    journal = "International Journal of Epidemiology",
    issn = "0300-5771",
    publisher = "Oxford University Press",
    number = "5",

    }

    Wormser, D, Di Angelantonio, E, Kaptoge, S, Wood, AM, Gao, P, Sun, Q, Walldius, G, Selmer, R, Verschuren, WMM, Bueno-de-Mesquita, HB, Engstrom, G, Ridker, PM, Njolstad, I, Iso, H, Holme, I, Giampaoli, S, Tunstall-Pedoe, H, Gaziano, JM, Brunner, E, Kee, F, Tosetto, A, Meisinger, C, Brenner, H, Ducimetiere, P, Whincup, PH, Tipping, RW, Ford, I, Cremer, P, Hofman, A, Wilhelmsen, L, Clarke, R, de Boer, IH, Jukema, JW, Ibanez, AM, Lawlor, DA, D'Agostino, RB, Rodriguez, B, Casiglia, E, Stehouwer, CDA, Simons, LA, Nietert, PJ, Barrett-Connor, E, Panagiotakos, DB, Bjorkelund, C, Strandberg, TE, Wassertheil-Smoller, S, Blazer, DG, Meade, TW, Welin, L, Woodward, M & Emerging Risk Factors Collaboratio 2012, 'Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis', International Journal of Epidemiology, vol. 41, no. 5, pp. 1419-1433. https://doi.org/10.1093/ije/dys086

    Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis. / Wormser, David; Di Angelantonio, Emanuele; Kaptoge, Stephen; Wood, Angela M.; Gao, Pei; Sun, Qi; Walldius, Goeran; Selmer, Randi; Verschuren, W. M. Monique; Bueno-de-Mesquita, H. Bas; Engstrom, Gunnar; Ridker, Paul M.; Njolstad, Inger; Iso, Hiroyasu; Holme, Ingar; Giampaoli, Simona; Tunstall-Pedoe, Hugh; Gaziano, J. Michael; Brunner, Eric; Kee, Frank; Tosetto, Alberto; Meisinger, Christa; Brenner, Hermann; Ducimetiere, Pierre; Whincup, Peter H.; Tipping, Robert W.; Ford, Ian; Cremer, Peter; Hofman, Albert; Wilhelmsen, Lars; Clarke, Robert; de Boer, Ian H.; Jukema, J. Wouter; Ibanez, Alejandro Marin; Lawlor, Debbie A.; D'Agostino, Ralph B.; Rodriguez, Beatriz; Casiglia, Edoardo; Stehouwer, Coen D. A.; Simons, Leon A.; Nietert, Paul J.; Barrett-Connor, Elizabeth; Panagiotakos, Demosthenes B.; Bjorkelund, Cecilia; Strandberg, Timo E.; Wassertheil-Smoller, Sylvia; Blazer, Dan G.; Meade, Tom W.; Welin, Lennart; Woodward, Mark; Emerging Risk Factors Collaboratio.

    In: International Journal of Epidemiology, Vol. 41, No. 5, 2012, p. 1419-1433.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis

    AU - Wormser, David

    AU - Di Angelantonio, Emanuele

    AU - Kaptoge, Stephen

    AU - Wood, Angela M.

    AU - Gao, Pei

    AU - Sun, Qi

    AU - Walldius, Goeran

    AU - Selmer, Randi

    AU - Verschuren, W. M. Monique

    AU - Bueno-de-Mesquita, H. Bas

    AU - Engstrom, Gunnar

    AU - Ridker, Paul M.

    AU - Njolstad, Inger

    AU - Iso, Hiroyasu

    AU - Holme, Ingar

    AU - Giampaoli, Simona

    AU - Tunstall-Pedoe, Hugh

    AU - Gaziano, J. Michael

    AU - Brunner, Eric

    AU - Kee, Frank

    AU - Tosetto, Alberto

    AU - Meisinger, Christa

    AU - Brenner, Hermann

    AU - Ducimetiere, Pierre

    AU - Whincup, Peter H.

    AU - Tipping, Robert W.

    AU - Ford, Ian

    AU - Cremer, Peter

    AU - Hofman, Albert

    AU - Wilhelmsen, Lars

    AU - Clarke, Robert

    AU - de Boer, Ian H.

    AU - Jukema, J. Wouter

    AU - Ibanez, Alejandro Marin

    AU - Lawlor, Debbie A.

    AU - D'Agostino, Ralph B.

    AU - Rodriguez, Beatriz

    AU - Casiglia, Edoardo

    AU - Stehouwer, Coen D. A.

    AU - Simons, Leon A.

    AU - Nietert, Paul J.

    AU - Barrett-Connor, Elizabeth

    AU - Panagiotakos, Demosthenes B.

    AU - Bjorkelund, Cecilia

    AU - Strandberg, Timo E.

    AU - Wassertheil-Smoller, Sylvia

    AU - Blazer, Dan G.

    AU - Meade, Tom W.

    AU - Welin, Lennart

    AU - Woodward, Mark

    AU - Emerging Risk Factors Collaboratio

    PY - 2012

    Y1 - 2012

    N2 - Background The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain.Methods We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies.Results For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators.Conclusion Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases.

    AB - Background The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain.Methods We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies.Results For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators.Conclusion Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases.

    U2 - 10.1093/ije/dys086

    DO - 10.1093/ije/dys086

    M3 - Article

    C2 - 22825588

    VL - 41

    SP - 1419

    EP - 1433

    JO - International Journal of Epidemiology

    JF - International Journal of Epidemiology

    SN - 0300-5771

    IS - 5

    ER -