Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease

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• Finished

  Genome-wide and chemical screens to uncover novel upstream regulators of the LRRK2 signaling network

  Alessi, D. (Investigator)

  1/08/19 → 30/09/21

  Project: Research

  • Leucine-rich Repeat Kinase 2 (LRRK2) 100%
  • LRRK2 76%
  • PPM1H 38%
  • Rab Proteins 36%
  • Phosphatase 33%

• Regulation of the Parkinson's kinase LRRK2

  Alessi, D. (Investigator)

  Parkinson's UK

  3/09/18 → 2/09/21

  Project: Research

  • Leucine-rich Repeat Kinase 2 (LRRK2) 100%
  • Leucine-Rich Repeat 91%
  • Kinase 85%
  • Phosphotransferase 85%
  • Parkinson's Disease 41%

• Towards a Unifying Theory of Parkinson's Disease - Investigation of the Biochemical and Genetic Role of Rab GTPases (joint with German Centre for Neurodegenerative Diseases)

  Alessi, D. (Investigator) & Muqit, M. (Investigator)

  Medical Research Council

  17/10/16 → 16/10/18

  Project: Research

  • Leucine-rich Repeat Kinase 2 (LRRK2) 100%
  • Leucine-Rich Repeat 69%
  • Kinase 66%
  • Phosphotransferase 66%
  • LRRK2 53%

• Aref#d: 21286. Mass Spectrometry-Based Global Analysis of Protein Phosphorylation in Cells and Tissue Extracts with Altered PINK1 Catalytic Activity: A Novel Screen for PINK1 Substrates

  Alessi, D. (Investigator) & Muqit, M. (Investigator)

  1/12/09 → 30/11/12

  Project: Research

  • Kinase 100%
  • Phosphotransferase 100%
  • Phosphorylation 95%
  • Parkin 69%
  • Leucine-rich Repeat Kinase 2 (LRRK2) 69%