Advances in Malaria Pharmacology and the online Guide to MALARIA PHARMACOLOGY: IUPHAR review 38

Jane F. Armstrong, Brice Campo (Lead / Corresponding author), Stephen P. H. Alexander, Lauren B. Arendse, Xiu Cheng, Anthony P. Davenport, Elena Faccenda, David A. Fidock, Karla P. Godinez-Macias, Simon D. Harding, Nobutaka Kato, Marcus C. S. Lee, Madeline R. Luth, Ralph Mazitschek, Nimisha Mittal, Jacquin C. Niles, John Okombo, Sabine Ottilie, Charisse Flerida A. Pasaje, Alexandra S. ProbstMukul Rawat, Frances Rocamora, Tomoyo Sakata-Kato, Christopher Southan, Michael Spedding, Mark A. Tye, Tuo Yang, Na Zhao, Jamie A. Davies (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)
53 Downloads (Pure)

Abstract

Antimalarial drug discovery has until recently been driven by high-throughput phenotypic cellular screening, allowing millions of compounds to be assayed and delivering clinical drug candidates. In this review, we will focus on target-based approaches, describing recent advances in our understanding of druggable targets in the malaria parasite. Targeting multiple stages of the Plasmodium lifecycle, rather than just the clinically symptomatic asexual blood stage, has become a requirement for new antimalarial medicines, and we link pharmacological data clearly to the parasite stages to which it applies. Finally, we highlight the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY, a web resource developed for the malaria research community that provides open and optimized access to published data on malaria pharmacology.

Original languageEnglish
Pages (from-to)1899-1929
Number of pages31
JournalBritish Journal of Pharmacology
Volume180
Issue number15
Early online date17 May 2023
DOIs
Publication statusPublished - Aug 2023

Keywords

  • bioinformatics
  • database
  • drug discovery
  • malaria
  • molecular target
  • Plasmodium

ASJC Scopus subject areas

  • Pharmacology

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