Advances in Malaria Pharmacology and the online Guide to MALARIA PHARMACOLOGY: IUPHAR review 38

Jane F. Armstrong; Brice Campo; Stephen P. H. Alexander; Lauren B. Arendse; Xiu Cheng; Anthony P. Davenport; Elena Faccenda; David A. Fidock; Karla P. Godinez-Macias; Simon D. Harding; Nobutaka Kato; Marcus C. S. Lee; Madeline R. Luth; Ralph Mazitschek; Nimisha Mittal; Jacquin C. Niles; John Okombo; Sabine Ottilie; Charisse Flerida A. Pasaje; Alexandra S. Probst; Mukul Rawat; Frances Rocamora; Tomoyo Sakata-Kato; Christopher Southan; Michael Spedding; Mark A. Tye; Tuo Yang; Na Zhao; Jamie A. Davies

doi:10.1111/bph.16144

Advances in Malaria Pharmacology and the online Guide to MALARIA PHARMACOLOGY: IUPHAR review 38

Jane F. Armstrong
, Brice Campo (Lead / Corresponding author)
, Stephen P. H. Alexander
, Lauren B. Arendse
, Xiu Cheng
, Anthony P. Davenport
, Elena Faccenda
, David A. Fidock
, Karla P. Godinez-Macias
, Simon D. Harding
, Nobutaka Kato
, Marcus C. S. Lee
, Madeline R. Luth
, Ralph Mazitschek
, Nimisha Mittal
, Jacquin C. Niles
, John Okombo
, Sabine Ottilie
, Charisse Flerida A. Pasaje
, Alexandra S. Probst

Mukul Rawat, Frances Rocamora, Tomoyo Sakata-Kato, Christopher Southan, Michael Spedding, Mark A. Tye, Tuo Yang, Na Zhao, Jamie A. Davies (Lead / Corresponding author)

Biological Chemistry and Drug Discovery

Research output: Contribution to journal › Review article › peer-review

12 Citations (Scopus)

257 Downloads (Pure)

Abstract

Antimalarial drug discovery has until recently been driven by high-throughput phenotypic cellular screening, allowing millions of compounds to be assayed and delivering clinical drug candidates. In this review, we will focus on target-based approaches, describing recent advances in our understanding of druggable targets in the malaria parasite. Targeting multiple stages of the Plasmodium lifecycle, rather than just the clinically symptomatic asexual blood stage, has become a requirement for new antimalarial medicines, and we link pharmacological data clearly to the parasite stages to which it applies. Finally, we highlight the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY, a web resource developed for the malaria research community that provides open and optimized access to published data on malaria pharmacology.

Original language	English
Pages (from-to)	1899-1929
Number of pages	31
Journal	British Journal of Pharmacology
Volume	180
Issue number	15
Early online date	17 May 2023
DOIs	https://doi.org/10.1111/bph.16144
Publication status	Published - Aug 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

bioinformatics
database
drug discovery
malaria
molecular target
Plasmodium

ASJC Scopus subject areas

Pharmacology

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10.1111/bph.16144Licence: CC BY

Final published versionFinal published version, 1.41 MBLicence: CC BY

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Armstrong, J. F., Campo, B., Alexander, S. P. H., Arendse, L. B., Cheng, X., Davenport, A. P., Faccenda, E., Fidock, D. A., Godinez-Macias, K. P., Harding, S. D., Kato, N., Lee, M. C. S., Luth, M. R., Mazitschek, R., Mittal, N., Niles, J. C., Okombo, J., Ottilie, S., Pasaje, C. F. A., ... Davies, J. A. (2023). Advances in Malaria Pharmacology and the online Guide to MALARIA PHARMACOLOGY: IUPHAR review 38. British Journal of Pharmacology, 180(15), 1899-1929. https://doi.org/10.1111/bph.16144

@article{79aee24fa9854dd2a8247fb9843c237e,

title = "Advances in Malaria Pharmacology and the online Guide to MALARIA PHARMACOLOGY: IUPHAR review 38",

abstract = "Antimalarial drug discovery has until recently been driven by high-throughput phenotypic cellular screening, allowing millions of compounds to be assayed and delivering clinical drug candidates. In this review, we will focus on target-based approaches, describing recent advances in our understanding of druggable targets in the malaria parasite. Targeting multiple stages of the Plasmodium lifecycle, rather than just the clinically symptomatic asexual blood stage, has become a requirement for new antimalarial medicines, and we link pharmacological data clearly to the parasite stages to which it applies. Finally, we highlight the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY, a web resource developed for the malaria research community that provides open and optimized access to published data on malaria pharmacology.",

keywords = "bioinformatics, database, drug discovery, malaria, molecular target, Plasmodium",

author = "Armstrong, \{Jane F.\} and Brice Campo and Alexander, \{Stephen P. H.\} and Arendse, \{Lauren B.\} and Xiu Cheng and Davenport, \{Anthony P.\} and Elena Faccenda and Fidock, \{David A.\} and Godinez-Macias, \{Karla P.\} and Harding, \{Simon D.\} and Nobutaka Kato and Lee, \{Marcus C. S.\} and Luth, \{Madeline R.\} and Ralph Mazitschek and Nimisha Mittal and Niles, \{Jacquin C.\} and John Okombo and Sabine Ottilie and Pasaje, \{Charisse Flerida A.\} and Probst, \{Alexandra S.\} and Mukul Rawat and Frances Rocamora and Tomoyo Sakata-Kato and Christopher Southan and Michael Spedding and Tye, \{Mark A.\} and Tuo Yang and Na Zhao and Davies, \{Jamie A.\}",

year = "2023",

month = aug,

doi = "10.1111/bph.16144",

language = "English",

volume = "180",

pages = "1899--1929",

journal = "British Journal of Pharmacology",

issn = "0007-1188",

publisher = "Wiley",

number = "15",

}

Armstrong, JF, Campo, B, Alexander, SPH, Arendse, LB, Cheng, X, Davenport, AP, Faccenda, E, Fidock, DA, Godinez-Macias, KP, Harding, SD, Kato, N, Lee, MCS, Luth, MR, Mazitschek, R, Mittal, N, Niles, JC, Okombo, J, Ottilie, S, Pasaje, CFA, Probst, AS, Rawat, M, Rocamora, F, Sakata-Kato, T, Southan, C, Spedding, M, Tye, MA, Yang, T, Zhao, N & Davies, JA 2023, 'Advances in Malaria Pharmacology and the online Guide to MALARIA PHARMACOLOGY: IUPHAR review 38', British Journal of Pharmacology, vol. 180, no. 15, pp. 1899-1929. https://doi.org/10.1111/bph.16144

TY - JOUR

T1 - Advances in Malaria Pharmacology and the online Guide to MALARIA PHARMACOLOGY

T2 - IUPHAR review 38

AU - Armstrong, Jane F.

AU - Campo, Brice

AU - Alexander, Stephen P. H.

AU - Arendse, Lauren B.

AU - Cheng, Xiu

AU - Davenport, Anthony P.

AU - Faccenda, Elena

AU - Fidock, David A.

AU - Godinez-Macias, Karla P.

AU - Harding, Simon D.

AU - Kato, Nobutaka

AU - Lee, Marcus C. S.

AU - Luth, Madeline R.

AU - Mazitschek, Ralph

AU - Mittal, Nimisha

AU - Niles, Jacquin C.

AU - Okombo, John

AU - Ottilie, Sabine

AU - Pasaje, Charisse Flerida A.

AU - Probst, Alexandra S.

AU - Rawat, Mukul

AU - Rocamora, Frances

AU - Sakata-Kato, Tomoyo

AU - Southan, Christopher

AU - Spedding, Michael

AU - Tye, Mark A.

AU - Yang, Tuo

AU - Zhao, Na

AU - Davies, Jamie A.

PY - 2023/8

Y1 - 2023/8

N2 - Antimalarial drug discovery has until recently been driven by high-throughput phenotypic cellular screening, allowing millions of compounds to be assayed and delivering clinical drug candidates. In this review, we will focus on target-based approaches, describing recent advances in our understanding of druggable targets in the malaria parasite. Targeting multiple stages of the Plasmodium lifecycle, rather than just the clinically symptomatic asexual blood stage, has become a requirement for new antimalarial medicines, and we link pharmacological data clearly to the parasite stages to which it applies. Finally, we highlight the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY, a web resource developed for the malaria research community that provides open and optimized access to published data on malaria pharmacology.

AB - Antimalarial drug discovery has until recently been driven by high-throughput phenotypic cellular screening, allowing millions of compounds to be assayed and delivering clinical drug candidates. In this review, we will focus on target-based approaches, describing recent advances in our understanding of druggable targets in the malaria parasite. Targeting multiple stages of the Plasmodium lifecycle, rather than just the clinically symptomatic asexual blood stage, has become a requirement for new antimalarial medicines, and we link pharmacological data clearly to the parasite stages to which it applies. Finally, we highlight the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY, a web resource developed for the malaria research community that provides open and optimized access to published data on malaria pharmacology.

KW - bioinformatics

KW - database

KW - drug discovery

KW - malaria

KW - molecular target

KW - Plasmodium

UR - https://www.scopus.com/pages/publications/85161693356

U2 - 10.1111/bph.16144

DO - 10.1111/bph.16144

M3 - Review article

C2 - 37197802

SN - 0007-1188

VL - 180

SP - 1899

EP - 1929

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 15

ER -

Advances in Malaria Pharmacology and the online Guide to MALARIA PHARMACOLOGY: IUPHAR review 38

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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