Abstract
Intracortical porosity can be defined as the percentage of pores in cortical bone, being affected by intrinsic and extrinsic factors such as age, sex, and pathology. The aim of this study is to investigate intracortical porosity in relation to intra-skeletal variation, sex, and age on the clavicle in an elderly sample.
Thirty Scottish individuals were included (15 males and 15 females; age range: 67-97 years). Ninety thin sections were produced from the medial, midshaft and lateral clavicular segments. Photomicrographs were analysed using Pore
Extractor 2D assessing cortical area (CA), total pore number (TPN), mean pore area (MPA), mean pore circularity (MPC) and cortical porosity (CP). Comparisons were made between anatomical segments, sexes, and age groups (70s, 80s and
90s) using different statistical tests. TPN and MPA in males, and CA and MPA in
females, produced statistically significant differences between clavicular segments. No statistically significant difference between anatomical segments was found for CP, suggesting that intra-skeletal variation is minimal
for this parameter. CA was significantly different between sexes in all clavicular segments, with the remaining parameters providing varying results depending on the segment under consideration. Age group differences were not reported.
This study provides further information about intracortical porosity in the clavicle for advanced age individuals. The effect of age-related pathologies
such as osteoporosis might explain the sex differences observed, and considerations of bone biomechanics could justify the reported intra-skeletal
variability. Moreover, age does not seem to alter intracortical porosity suggesting no significant change in the last three decades of life.
Part of: Symposium: Bridging Disciplines with Bone Biology
Thirty Scottish individuals were included (15 males and 15 females; age range: 67-97 years). Ninety thin sections were produced from the medial, midshaft and lateral clavicular segments. Photomicrographs were analysed using Pore
Extractor 2D assessing cortical area (CA), total pore number (TPN), mean pore area (MPA), mean pore circularity (MPC) and cortical porosity (CP). Comparisons were made between anatomical segments, sexes, and age groups (70s, 80s and
90s) using different statistical tests. TPN and MPA in males, and CA and MPA in
females, produced statistically significant differences between clavicular segments. No statistically significant difference between anatomical segments was found for CP, suggesting that intra-skeletal variation is minimal
for this parameter. CA was significantly different between sexes in all clavicular segments, with the remaining parameters providing varying results depending on the segment under consideration. Age group differences were not reported.
This study provides further information about intracortical porosity in the clavicle for advanced age individuals. The effect of age-related pathologies
such as osteoporosis might explain the sex differences observed, and considerations of bone biomechanics could justify the reported intra-skeletal
variability. Moreover, age does not seem to alter intracortical porosity suggesting no significant change in the last three decades of life.
Part of: Symposium: Bridging Disciplines with Bone Biology
| Original language | English |
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| Publication status | Published - 21 Mar 2024 |
| Event | 93rd Annual Meeting of the American Association of Biological Anthropologists - Los Angeles, United States - JW Marriott, Los Angeles, United States Duration: 20 Mar 2024 → 23 Mar 2024 Conference number: 93 https://bioanth.org/93rd-annual-meeting-los-angeles-california-2024/ (AABA 93rd Annual Meeting, Los Angeles, California (2024) information) |
Conference
| Conference | 93rd Annual Meeting of the American Association of Biological Anthropologists - Los Angeles, United States |
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| Abbreviated title | AABA LA 2024 |
| Country/Territory | United States |
| City | Los Angeles |
| Period | 20/03/24 → 23/03/24 |
| Internet address |
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