Ageing and vitamin D deficiency: effects on calcium homeostasis and considerations for vitamin D supplementation

Christian Oudshoom; Tischa J. M. van der Cammen; Marion E. T. McMurdo; Johannes P. T. M. van Leeuwen; Edgar M. Colin

doi:10.1017/S0007114509338842

Ageing and vitamin D deficiency: effects on calcium homeostasis and considerations for vitamin D supplementation

Christian Oudshoom, Tischa J. M. van der Cammen, Marion E. T. McMurdo, Johannes P. T. M. van Leeuwen, Edgar M. Colin

Research output: Contribution to journal › Review article › peer-review

43 Citations (Scopus)

Abstract

Vitamin D is a fat-soluble, seco-steroid hormone. In man, the vitamin D receptor is expressed in almost all tissues, enabling effects in multiple systems of the human body. These effects can be endocrine, paracrine and autocrine. The present review summarises the effects of ageing on the vitamin D endocrine system and on Ca homeostasis. Furthermore, consequences for vitamin D supplementation are discussed.

Original language	English
Pages (from-to)	1597-1606
Number of pages	10
Journal	British Journal of Nutrition
Volume	101
Issue number	11
DOIs	https://doi.org/10.1017/S0007114509338842
Publication status	Published - 14 Jun 2009

Keywords

Vitamin D
Calcium
Vitamin D receptor
Ageing
Vitamin D resistance
Supplementation
PARATHYROID-HORMONE LEVELS
NURSING-HOME RESIDENTS
AGE-RELATED-CHANGES
D-RECEPTOR
1,25-DIHYDROXYVITAMIN D-3
HYPERVITAMINOSIS-D
25-HYDROXYVITAMIN D-3-1-ALPHA-HYDROXYLASE
HUMAN KERATINOCYTES
KNOCKOUT MICE
D METABOLISM

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title = "Ageing and vitamin D deficiency: effects on calcium homeostasis and considerations for vitamin D supplementation",

abstract = "Vitamin D is a fat-soluble, seco-steroid hormone. In man, the vitamin D receptor is expressed in almost all tissues, enabling effects in multiple systems of the human body. These effects can be endocrine, paracrine and autocrine. The present review summarises the effects of ageing on the vitamin D endocrine system and on Ca homeostasis. Furthermore, consequences for vitamin D supplementation are discussed.",

keywords = "Vitamin D, Calcium, Vitamin D receptor, Ageing, Vitamin D resistance, Supplementation, PARATHYROID-HORMONE LEVELS, NURSING-HOME RESIDENTS, AGE-RELATED-CHANGES, D-RECEPTOR, 1,25-DIHYDROXYVITAMIN D-3, HYPERVITAMINOSIS-D, 25-HYDROXYVITAMIN D-3-1-ALPHA-HYDROXYLASE, HUMAN KERATINOCYTES, KNOCKOUT MICE, D METABOLISM",

author = "Christian Oudshoom and {van der Cammen}, {Tischa J. M.} and McMurdo, {Marion E. T.} and {van Leeuwen}, {Johannes P. T. M.} and Colin, {Edgar M.}",

year = "2009",

month = jun,

day = "14",

doi = "10.1017/S0007114509338842",

language = "English",

volume = "101",

pages = "1597--1606",

journal = "British Journal of Nutrition",

issn = "0007-1145",

publisher = "Cambridge University Press",

number = "11",

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TY - JOUR

T1 - Ageing and vitamin D deficiency

T2 - effects on calcium homeostasis and considerations for vitamin D supplementation

AU - Oudshoom, Christian

AU - van der Cammen, Tischa J. M.

AU - McMurdo, Marion E. T.

AU - van Leeuwen, Johannes P. T. M.

AU - Colin, Edgar M.

PY - 2009/6/14

Y1 - 2009/6/14

N2 - Vitamin D is a fat-soluble, seco-steroid hormone. In man, the vitamin D receptor is expressed in almost all tissues, enabling effects in multiple systems of the human body. These effects can be endocrine, paracrine and autocrine. The present review summarises the effects of ageing on the vitamin D endocrine system and on Ca homeostasis. Furthermore, consequences for vitamin D supplementation are discussed.

AB - Vitamin D is a fat-soluble, seco-steroid hormone. In man, the vitamin D receptor is expressed in almost all tissues, enabling effects in multiple systems of the human body. These effects can be endocrine, paracrine and autocrine. The present review summarises the effects of ageing on the vitamin D endocrine system and on Ca homeostasis. Furthermore, consequences for vitamin D supplementation are discussed.

KW - Vitamin D

KW - Calcium

KW - Vitamin D receptor

KW - Ageing

KW - Vitamin D resistance

KW - Supplementation

KW - PARATHYROID-HORMONE LEVELS

KW - NURSING-HOME RESIDENTS

KW - AGE-RELATED-CHANGES

KW - D-RECEPTOR

KW - 1,25-DIHYDROXYVITAMIN D-3

KW - HYPERVITAMINOSIS-D

KW - 25-HYDROXYVITAMIN D-3-1-ALPHA-HYDROXYLASE

KW - HUMAN KERATINOCYTES

KW - KNOCKOUT MICE

KW - D METABOLISM

U2 - 10.1017/S0007114509338842

DO - 10.1017/S0007114509338842

M3 - Review article

C2 - 19393111

SN - 0007-1145

VL - 101

SP - 1597

EP - 1606

JO - British Journal of Nutrition

JF - British Journal of Nutrition

IS - 11

ER -

Ageing and vitamin D deficiency: effects on calcium homeostasis and considerations for vitamin D supplementation

Abstract

Keywords

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