Ageing and vitamin D deficiency: effects on calcium homeostasis and considerations for vitamin D supplementation

Christian Oudshoom, Tischa J. M. van der Cammen, Marion E. T. McMurdo, Johannes P. T. M. van Leeuwen, Edgar M. Colin

    Research output: Contribution to journalReview article

    30 Citations (Scopus)

    Abstract

    Vitamin D is a fat-soluble, seco-steroid hormone. In man, the vitamin D receptor is expressed in almost all tissues, enabling effects in multiple systems of the human body. These effects can be endocrine, paracrine and autocrine. The present review summarises the effects of ageing on the vitamin D endocrine system and on Ca homeostasis. Furthermore, consequences for vitamin D supplementation are discussed.

    Original languageEnglish
    Pages (from-to)1597-1606
    Number of pages10
    JournalBritish Journal of Nutrition
    Volume101
    Issue number11
    DOIs
    Publication statusPublished - 14 Jun 2009

    Keywords

    • Vitamin D
    • Calcium
    • Vitamin D receptor
    • Ageing
    • Vitamin D resistance
    • Supplementation
    • PARATHYROID-HORMONE LEVELS
    • NURSING-HOME RESIDENTS
    • AGE-RELATED-CHANGES
    • D-RECEPTOR
    • 1,25-DIHYDROXYVITAMIN D-3
    • HYPERVITAMINOSIS-D
    • 25-HYDROXYVITAMIN D-3-1-ALPHA-HYDROXYLASE
    • HUMAN KERATINOCYTES
    • KNOCKOUT MICE
    • D METABOLISM

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